Recombinant Anti-AXL (AA 1-134 x AA 222-234) Biparatopic Antibody, Tandem scFv
CAT#: VS-0525-YC20
The recombinant Anti-AXL (AA 1-134 x AA 222-234) biparatopic antibody, tandem scFv, is developed to attach to two distinct sites on AXL. It is engineered as a tandem scFv that engages with amino acids 1-134 and 222-234 on the human Axl protein at the same time.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane, actin filaments & vesicles.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/75217/1899_C1_1_selected.jpg
Normal Tissue
Figure 2 IHC staining of human thyroid gland
Immunohistochemical staining of human thyroid gland shows strong cytoplasmic positivity in glandular cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/32501/ihc_selected.jpg
Normal Tissue
Figure 3 Skeletal muscle
Myocytes Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/37422/82809_B_1_6.jpg
Normal Tissue
Figure 4 Colon
Glandular cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/37422/82809_A_8_3.jpg
Normal Tissue
Figure 5 Kidney
Cells in glomeruli Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous Cells in tubules Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/37422/82809_A_9_5.jpg
Normal Tissue
Figure 6 Testis
Cells in seminiferous ducts Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/37422/82809_A_4_6.jpg
RNA Expression
Figure 7 RNA cell line category: Cell line enhanced (fHDF/TERT166, U-251 MG)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000167601-AXL
❮
❯
Specifications
- Host Animal 1
- Human
- Host Animal 2
- Human
- Specificity
- Human AXL
- Species Reactivity
- Human, Mouse
- Type
- Tandem scFv
- Valency
- 1 + 1
- Epitope 1
- aa 1-134 of human Axl.
- Epitope 2
- aa 222-234 of human Axl.
- Purity
- >90%
- Purification
- Affinity purified
- Applications
- Block, ELISA, FC, IHC, SPR, WB
- Concentration
- Lot specific
- Buffer
- PBS, pH 7.4
- Preservative
- No preservatives
- Storage
- Store at 4°C for short term. Aliquot and store at -20°C for long term. Avoid freeze-thaw cycles.
- Long Name
- AXL Receptor Tyrosine Kinase
Target
- Introduction
- The protein encoded by this gene is a member of the Tyro3-Axl-Mer (TAM) receptor tyrosine kinase subfamily. The encoded protein possesses an extracellular domain which is composed of two immunoglobulin-like motifs at the N-terminal, followed by two fibronectin type-III motifs. It transduces signals from the extracellular matrix into the cytoplasm by binding to the vitamin K-dependent protein growth arrest-specific 6 (Gas6). This gene may be involved in several cellular functions including growth, migration, aggregation and anti-inflammation in multiple cell types. Alternative splicing results in multiple transcript variants of this gene.
- Alternative Names
- ARK; UFO; JTK11; Tyro7
- Gene ID
- 558
- UniProt ID
- P30530
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Related Diseases
EGFR Tyrosine Kinase Inhibitor Resistance
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Datasheet
MSDS
COA
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Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0138CL-F(E) | Mouse Anti-AXL Recombinant Antibody Fab Fragment (TAB-0138CL-S(P)) | ELISA, IF, FC, Inhib, ICFC | |
| TAB-0188CL-F(E) | Mouse Anti-AXL Recombinant Antibody; Fab Fragment (TAB-0188CL-F(E)) | WB, FuncS, ELISA, FC | Mouse Fab |
| TAB-1087CL-F(E) | Human Anti-AXL Recombinant Antibody; Fab Fragment (TAB-1087CL-F(E)) | ELISA, FuncS | Chimeric (mouse/human) Fab |
| TAB-1088CL-F(E) | Human Anti-AXL Recombinant Antibody; Fab Fragment (TAB-1088CL-F(E)) | ELISA, FuncS | Chimeric (mouse/human) Fab |
| TAB-1089CL-F(E) | Human Anti-AXL Recombinant Antibody; Fab Fragment (TAB-1089CL-F(E)) | ELISA, FuncS | Chimeric (mouse/human) Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0189CL-F(E) | Human Anti-AXL Recombinant Antibody; Fab Fragment (TAB-0189CL-F(E)) | WB, FuncS, ELISA, FC | Chimeric (Mouse/Human) Fab |
| TAB-1090CL-F(E) | Human Anti-AXL Recombinant Antibody; Fab Fragment (TAB-1090CL-F(E)) | ELISA, FuncS | Chimeric (mouse/human) Fab |
| TAB-1091CL-F(E) | Human Anti-AXL Recombinant Antibody; Fab Fragment (TAB-1091CL-F(E)) | ELISA, FuncS | Chimeric (mouse/human) Fab |
| TAB-1092CL-F(E) | Human Anti-AXL Recombinant Antibody; Fab Fragment (TAB-1092CL-F(E)) | ELISA, FuncS | Chimeric (mouse/human) Fab |
| TAB-1071CLV | Human Anti-AXL Recombinant Antibody (TAB-1071CLV) | ADCC, FuncS | Chimeric (mouse/human) IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3970 | Hi-Affi™ Rabbit Anti-AXL Recombinant Antibody (clone SI30DS) | ELISA | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
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| HPAB-0601-CN | Human Anti-AXL Recombinant Antibody (HPAB-0601-CN) | ELISA, FC, IHC, Block | Human IgG |
| HPAB-0603-CN | Human Anti-AXL Recombinant Antibody (HPAB-0603-CN) | WB, ELISA, FC, IHC | Chimeric (Mouse/Human) IgG1, κ |
| HPAB-0604-CN | Mouse Anti-AXL Recombinant Antibody (HPAB-0604-CN) | ELISA, IHC | Mouse IgG1, κ |
| HPAB-0108-LS | Mouse Anti-AXL Recombinant Antibody (HPAB-0108-LS) | ELISA, FC, SPR, FuncS | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1616LY-F(E) | Human Anti-AXL Recombinant Antibody; Fab Fragment (HPAB-1616LY-F(E)) | ELISA | Humanized Fab |
| HPAB-1617LY-F(E) | Human Anti-AXL Recombinant Antibody; Fab Fragment (HPAB-1617LY-F(E)) | ELISA | Humanized Fab |
| HPAB-1618LY-F(E) | Human Anti-AXL Recombinant Antibody; Fab Fragment (HPAB-1618LY-F(E)) | ELISA | Humanized Fab |
| HPAB-1619LY-F(E) | Human Anti-AXL Recombinant Antibody; Fab Fragment (HPAB-1619LY-F(E)) | ELISA | Humanized Fab |
| HPAB-1850LY-F(E) | Mouse Anti-AXL Recombinant Antibody; Fab Fragment (HPAB-1850LY-F(E)) | ELISA, IA, FC, IHC, WB, IP | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-625-FY-S(P) | Mouse Anti-AXL Recombinant Antibody; scFv Fragment (HPAB-625-FY-S(P)) | WB, Inhib | Mouse scFv |
| HPAB-626-FY-S(P) | Mouse Anti-AXL Recombinant Antibody; scFv Fragment (HPAB-626-FY-S(P)) | Inhib | Mouse scFv |
| HPAB-M0416-YC-S(P) | Human Anti-AXL Recombinant Antibody; scFv Fragment (HPAB-M0416-YC-S(P)) | ELISA | Human scFv |
| HPAB-1850LY-S(P) | Mouse Anti-AXL Recombinant Antibody; scFv Fragment (HPAB-1850LY-S(P)) | ELISA, IA, FC, IHC, WB, IP | Mouse scfv |
| HPAB-1851LY-S(P) | Mouse Anti-AXL Recombinant Antibody; scFv Fragment (HPAB-1851LY-S(P)) | ELISA, IA, FC, IHC, WB, IP | Mouse scfv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0424-XY26 | AbPlus™ Anti-AXL Magnetic Beads (VS-0424-XY26) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| VS-0425-YC363 | Recombinant Anti-AXL Vesicular Antibody, EV Displayed (VS-0425-YC363) | ELISA, FC, Inhib, Cell-uptake |
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