Anti-CD2 (clone 35.1) Recombinant Antibody Coupled Liposome (VS-1024-FY269)
CAT#: VS-1024-FY269
Anti-CD2 liposomes represent an innovative drug delivery system that utilizes the specific binding properties of anti-CD2 antibodies to enhance the targeting and efficacy of therapeutic agents in cells, particularly leukemia cells that express the corresponding receptor. This targeted approach facilitates effective drug loading and expands the potential applications of the therapy in tumor immunotherapy.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line JURKAT
Immunofluorescent staining of human cell line JURKAT shows localization to nucleoplasm, plasma membrane & the Golgi apparatus.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/3883/2036_G3_1_selected.jpg
Normal Tissue
Figure 2 Lymph node
Germinal center cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/3883/11413_A_8_8.jpg
Normal Tissue
Figure 3 Tonsil
Germinal center cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/3883/11413_A_4_8.jpg
RNA Expression
Figure 4 RNA cell line category: Group enriched (HDLM-2, JURKAT, MOLT-4)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000116824-CD2
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More Infomation
Specifications
- Potential Clinical Applications
- The specific potential of anti-CD2 immunoliposomes for the treatment of leukemia.
Product Composition
- Clone
- 35.1
- Antibody Type
- IgG1, kappa
- Antibody Host
- Human
- Antibody Reactivity
- Human
- Antibody Description
- This is a human IgG1 kappa that targets CD2. It has demonstrated significant immunomodulatory effects by selectively inhibiting the activity of T and NK cells. Currently under investigation as a potential treatment for psoriasis and as a preventive measure for graft-versus-host disease, this agent offers promising therapeutic prospects.
Product Property
- Storage
- See in the COA
- Storage Shelf Time
- See in the COA
Target Information
- Target
- CD2
- Full Name
- CD2 Molecule
- Cellular Localization
- Cell membrane, Membrane
- Protein Refseq
- NP_001315538.1; NP_001758.2
- Function
- CD2 interacts with lymphocyte function-associated antigen CD58 (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T-cells, the cytoplasmic domain is implicated in the signaling function.
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Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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