Mouse Anti-CD276 Recombinant Antibody (HPAB-0048LY) (CAT#: HPAB-0048LY)
This product is a mouse-derived IgG monoclonal antibody expressed by hybridoma cells, specifically targeting the human B7-H3 protein. The anti-B7-H3 antibody recognizes cancer stem cell lines, regulates angiogenic factor secretion, and exhibits potent antitumor activity in vivo. HPAB-0048LY significantly reduced VEGF secretion by up to 60% in the subset of cancer stem cell lines examined.
We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.

(Immunofluorescent staining of human cell line A-431 shows localization to vesicles.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/17139/if_selected.jpg

(High expression in placenta)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/17826/40943_A_1_7_val_selected.jpg

(Cells in seminiferous ducts Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/9285/25731_A_5_6.jpg

(Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/9285/25731_B_7_5.jpg

(Endothelial cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/9285/25731_A_9_3.jpg

(Cholangiocytes Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous Hepatocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/9285/25731_A_7_4.jpg

(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000103855-CD276
Specifications
- Immunogen
- Human fetal testis cells as an immunogen.
- Host Species
- Mouse
- Type
- Mouse IgG
- Specificity
- The antibody is binding to the IgV1-IgC1 portion of B7-H3.
- Species Reactivity
- Human
- Applications
- FuncS, ELISA, FC, IHC
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Immunohistochemistry: 1.25 μg/mL-5 μg/mL
Target
- Alternative Names
- CD276 Molecule; CD276 Antigen; Costimulatory Molecule; B7 Homolog 3; 4Ig-B7-H3; B7-H3; B7H3; B7RP-2;
- Gene ID
- 80381
- UniProt ID
- Q5ZPR3
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "CD276"
Select a product category from the dropdown menu below to view related products.
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-117CL | Anti-Human CD276 Recombinant Antibody (TAB-117CL) | ADCC, FuncS | Antibody |
TAB-424CQ | Anti-Human CD276 Recombinant Antibody (TAB-424CQ) | ELISA, IHC, FC, IP, IF, FuncS | IgG1, κ |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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