Afuco™ Anti-CD276 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-424CQ)
CAT#: AFC-TAB-424CQ
This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant monoclonal antibody to CD276. It is a humanized monoclonal antibody that can be potentially used in the treatment of Solid tumors.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to vesicles.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/17139/if_selected.jpg
Normal Tissue
Figure 2 Placenta.
High expression in placenta
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/17826/40943_A_1_7_val_selected.jpg
Normal Tissue
Figure 3 Testis
Cells in seminiferous ducts Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/9285/25731_A_5_6.jpg
Normal Tissue
Figure 4 Cerebral cortex
Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/9285/25731_B_7_5.jpg
Normal Tissue
Figure 5 Colon
Endothelial cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/9285/25731_A_9_3.jpg
Normal Tissue
Figure 6 Liver
Cholangiocytes Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous Hepatocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/9285/25731_A_7_4.jpg
RNA Expression
Figure 7 RNA cell line category: Cell line enhanced (HaCaT, U-2197)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000103855-CD276
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Specifications
- Immunogen
- The details of the immunogen for this antibody are not available.
- Host Species
- Human
- Derivation
- Humanized
- Type
- ADCC enhanced antibody
- Specificity
- Human CD276
- Species Reactivity
- Human
- Applications
- ELISA, IHC, FC, IP, IF, FuncS
- Conjugate
- Unconjugated
- Generic Name
- Enoblituzumab
- Related Disease
- Solid tumors
Product Property
- Purity
- >95% by SDS-PAGE
- Storage
- Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
REVIEWS AND Q&AS
CITATIONS
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User-friendly Preparation
Preparing Enoblituzumab for experiments was straightforward. Thawing on ice and gentle pipetting ensured the antibody's integrity, making our workflow efficient and error-free.
Superior ADCC Enhancement
Compared to other antibodies we've used, Enoblituzumab showed significantly enhanced ADCC activity. It's an excellent tool for functional assays where robust immune engagement is essential.
Highly Synergistic
When used alongside other therapeutic antibodies, Enoblituzumab exhibited strong synergistic effects, leading to improved antitumor responses in our combination therapy studies.
Q&As
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Is it possible to do research on ADCC processes in cancer cells with enutituzumab?
A: Yes, Enoblituzumab is specifically designed to target CD276, which is overexpressed in various types of cancer cells, making it an ideal tool for studying Antibody-Dependent Cellular Cytotoxicity (ADCC) mechanisms in oncology research.
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How well does enotezumab conjugate when used in bioimaging investigations?
A: Enoblituzumab can be conjugated with various fluorophores or enzymes suitable for immunofluorescence or immunohistochemistry applications, allowing for precise localization and quantification of CD276 expression.
-
Is it possible to utilize enotuzumab in conjunction with other therapeutic antibodies to achieve synergistic effects?
A: Yes, Enoblituzumab can be combined with other therapeutic antibodies that target distinct cancer markers, potentially leading to synergistic antitumor effects through combined mechanisms of action.
View the frequently asked questions answered by Creative Biolabs Support.
Cite This Product
To accurately reference this product in your publication, please use the following citation information:
(Creative Biolabs Cat# AFC-TAB-424CQ, RRID: AB_3111284)
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Biosimilar Overview
Please refer to Enoblituzumab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Enoblituzumab.
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
See other products for "CD276"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-117CL | Anti-Human CD276 Recombinant Antibody (TAB-117CL) | ADCC, FuncS | Antibody |
| TAB-424CQ | Anti-Human CD276 Recombinant Antibody (TAB-424CQ) | ELISA, IHC, FC, IP, IF, FuncS | IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1603MZ | Mouse Anti-CD276 Recombinant Antibody (clone NJI53) | FC | Mouse IgG1 |
| HPAB-M0422-YC | Mouse Anti-CD276 Recombinant Antibody (HPAB-M0422-YC) | Cyt, FuncS | Mouse IgG |
| HPAB-M0423-YC | Mouse Anti-CD276 Recombinant Antibody (HPAB-M0423-YC) | Cyt, FuncS | Mouse IgG |
| HPAB-M0424-YC | Human Anti-CD276 Recombinant Antibody (HPAB-M0424-YC) | Cyt, FuncS, IHC | Humanized IgG |
| HPAB-M0425-YC | Mouse Anti-CD276 Recombinant Antibody (HPAB-M0425-YC) | Cyt, FuncS | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-333CQ | Rat Anti-CD276 Recombinant Antibody (clone MJ18) | Block, FC | Rat IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0549 | Hi-Affi™ Rabbit Anti-CD276 Recombinant Antibody (clone DS549AB) | WB, IP, FC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0234-CN-F(E) | Human Anti-CD276 Recombinant Antibody; Fab Fragment (HPAB-0234-CN-F(E)) | ELISA, FC, IF | Human Fab |
| HPAB-0236-CN-F(E) | Mouse Anti-CD276 Recombinant Antibody; Fab Fragment (HPAB-0236-CN-F(E)) | ELISA, FC, IHC | Mouse Fab |
| HPAB-0237-CN-F(E) | Mouse Anti-CD276 Recombinant Antibody; Fab Fragment (HPAB-0237-CN-F(E)) | ELISA, FC, IHC | Mouse Fab |
| HPAB-0238-CN-F(E) | Mouse Anti-CD276 Recombinant Antibody; Fab Fragment (HPAB-0238-CN-F(E)) | ELISA, FC, IHC | Mouse Fab |
| HPAB-0239-CN-F(E) | Human Anti-CD276 Recombinant Antibody; Fab Fragment (HPAB-0239-CN-F(E)) | ELISA, FC, IHC | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-M0422-YC-S(P) | Mouse Anti-CD276 Recombinant Antibody; scFv Fragment (HPAB-M0422-YC-S(P)) | Cyt, FuncS | Mouse scFv |
| HPAB-M0423-YC-S(P) | Mouse Anti-CD276 Recombinant Antibody; scFv Fragment (HPAB-M0423-YC-S(P)) | Cyt, FuncS | Mouse scFv |
| HPAB-M0424-YC-S(P) | Human Anti-CD276 Recombinant Antibody; scFv Fragment (HPAB-M0424-YC-S(P)) | Cyt, FuncS, IHC | Human scFv |
| HPAB-M0425-YC-S(P) | Mouse Anti-CD276 Recombinant Antibody; scFv Fragment (HPAB-M0425-YC-S(P)) | Cyt, FuncS | Mouse scFv |
| HPAB-M0426-YC-S(P) | Human Anti-CD276 Recombinant Antibody; scFv Fragment (HPAB-M0426-YC-S(P)) | Cyt, FuncS, IHC | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0724-YC1279 | AbPlus™ Anti-Cd276 Magnetic Beads (VS-0724-YC1279) | IP, Protein Purification | |
| VS-0724-YC1280 | AbPlus™ Anti-Cd276 Magnetic Beads (VS-0724-YC1280) | IP, Protein Purification | |
| VS-0724-YC1366 | AbPlus™ Anti-CD276 Magnetic Beads (VS-0724-YC1366) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-FY67 | Human Anti-CD276 (clone MGA271) scFv-Fc Chimera | ADCC | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC156 | Recombinant Anti-CD276 Vesicular Antibody, EV Displayed (VS-0425-YC156) | ELISA, FC, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY1155 | Anti-CD276 Immunohistochemistry Kit | IHC | |
| VS-0525-XY1156 | Anti-Mouse CD276 Immunohistochemistry Kit | IHC |
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