Afuco™ Anti-CD40LG ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-027)

Name: Afuco™ Anti-CD40LG ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-027)
SKU: AFC-TAB-027
Rating: 5 (1 reviews)

CAT#: AFC-TAB-027

This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant monoclonal antibody to Human CD40L. It is a humanized monoclonal antibody intended for the treatment of rheumatic diseases like systemic lupus erythematosus and lupus nephritis.

Gene Expression

Subcellular Location Figure 1 IF staining of human cell line JURKAT

Immunofluorescent staining of human cell line JURKAT shows localization to plasma membrane.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/72480/2010_G3_1_selected.jpg

Subcellular Location Figure 2 IF staining of human cell line HEL

Immunofluorescent staining of human cell line HEL shows localization to golgi apparatus.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/72480/2069_B6_2_blue_green.jpg

Normal Tissue Figure 3 Colon

Mucosal lymphoid cells
Staining: Medium
Intensity: Strong
Quantity: <25%

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/72480/169295_A_9_3.jpg

Normal Tissue Figure 4 Lymph node

Non-germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/72480/169295_A_9_8.jpg

RNA Expression Figure 5 RNA cell line category: Cell line enriched (MOLT-4)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000102245-CD40LG

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Specifications

Immunogen
Animals were immunized with D1.1 cells.

Host Species
Human

Derivation
Humanized (from mouse)

Type
ADCC enhanced antibody

Species Reactivity
Human

Applications
IF, IP, Neut, FuncS, ELISA, FC

Conjugate
Unconjugated

Generic Name
Ruplizumab

Related Disease
Allograft rejection

Product Property

Purity
>95% by SDS-PAGE

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Alternative Names
CD40LG; CD40 ligand; HIGM1, IMD3, TNFSF5, tumor necrosis factor (ligand) superfamily, member 5 (hyper IgM syndrome); CD40 antigen ligand; CD40L; CD154; gp39; hCD40L; hyper IgM syndrome;

Gene ID
959

UniProt ID
P29965

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Downloadable Resources

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Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

Datasheet - AFC-TAB-027.pdf

MSDS

MSDS - AFC-TAB-027.pdf

COA

Certificate of Analysis Lookup

To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.

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Protocol & Troubleshooting

Immunofluorescence (IF)

We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.

See other products for "Ruplizumab"

DrugMonitor™ Anti-Ruplizumab Antibody (VS-1224-YC1046)
Ruplizumab is a humanized monoclonal antibody used as an immunosuppressive medication, developed for treating rheumatic diseases like systemic lupus erythematosus and lupus nephritis. The DrugMonitor™ Anti-Ruplizumab Antibody (VS-1224-YC1046) is an anti-drug antibody (ADA) against Ruplizumab. This drug-based antibody is raised in mice immunized with the Ruplizumab. The anti-Ruplizumab antibody may be used in ELISA, pharmacokinetics (PK), and pharmacodynamics (PD) analyses, or serves as a reference standard in ADA assays. It also is an excellent tool for therapeutic drug monitoring, allowing to evaluate the drug efficacy and determine the drug concentration of the Ruplizumab in samples.

See other products for "CD40LG"

Select a product category from the dropdown menu below to view related products.

CAT	Product Name	Application	Type
TAB-876	Anti-Human CD40 ligand Recombinant Antibody (Toralizumab)	ELISA, FC, IP, FuncS, IF, Neut, ICC	IgG1 - kappa
TAB-211LC	Human Anti-CD40LG Recombinant Antibody (TAB-211LC)	ELISA	Human IgG, κ
TAB-210LC-S(P)	Human Anti-CD40LG Recombinant Antibody; scFv Fragment (TAB-210LC-S(P))	ELISA	Humanized scFv
TAB-210LC-F(E)	Human Anti-CD40LG Recombinant Antibody; Fab Fragment (TAB-210LC-F(E))	ELISA	Humanized Fab
TAB-211LC-F(E)	Human Anti-CD40LG Recombinant Antibody; Fab Fragment (TAB-211LC-F(E))	ELISA	Humanized Fab

CAT	Product Name	Application
AGTO-G080E	Anti-Cd40lg immunotoxin LL2 (IgG)-PE	Cytotoxicity assay, Function study
AGTO-G081E	Anti-Cd40lg immunotoxin LL2 (Fab)-PE	Cytotoxicity assay, Function study
AGTO-L051P	anti-CD40LG immunotoxin MR1 (scFv)-PAP	Cytotoxicity assay, Functional assay

CAT	Product Name	Application	Type
PFBW-020	Human Anti-CD40LG Recombinant Antibody; Fab Fragment (PFBW-020)	Neut	Human Fab
HPAB-0179-YC-F(E)	Human Anti-CD40LG Recombinant Antibody; Fab Fragment (HPAB-0179-YC-F(E))	ELISA	Human Fab
FAMAB-0135-YC-F(E)	Hamster Anti-CD40LG Recombinant Antibody (clone mr-1); Fab Fragment	ELISA	Hamster Fab
HPAB-0744LY-F(E)	Human Anti-CD40LG Recombinant Antibody; Fab Fragment (HPAB-0744LY-F(E))	ELISA	Human Fab
HPAB-0880LY-F(E)	Mouse Anti-CD40LG Recombinant Antibody; Fab Fragment (HPAB-0880LY-F(E))	FC	Mouse Fab

CAT	Product Name	Application	Type
PSBW-020	Human Anti-CD40LG Recombinant Antibody; scFv Fragment (PSBW-020)	Neut	Human scFv
HPAB-0179-YC-S(P)	Human Anti-CD40LG Recombinant Antibody; scFv Fragment (HPAB-0179-YC-S(P))	ELISA	Human scFv
FAMAB-0135-YC-S(P)	Hamster Anti-CD40LG Recombinant Antibody (clone mr-1); scFv Fragment	ELISA	Hamster scFv
HPAB-0880LY-S(P)	Mouse Anti-CD40LG Recombinant Antibody; scFv Fragment (HPAB-0880LY-S(P))	FC	Mouse scFv
HPAB-0585-WJ-S(P)	Human Anti-CD40LG Recombinant Antibody; scFv Fragment (HPAB-0585-WJ-S(P))	ELISA	Human scFv

CAT	Product Name	Application
TAB-212LC	Mouse Anti-Human CD40LG Recombinant Antibody (ABI793)	Block
TAB-212LC-S(P)	Anti-Human CD40LG Recombinant Antibody scFv Fragment (ABI793)	ELISA
TAB-212LC-F(E)	Anti-Human CD40LG Recombinant Antibody Fab Fragment (ABI793)	ELISA

CAT	Product Name	Application	Type
TAB-225LC	Anti-Human CD40LG Recombinant Antibody (YMF323.6)	ELISA	Chimeric antibody (hamster/human)
TAB-225LC-S(P)	Anti-Human CD40LG Recombinant Antibody scFv Fragment (YMF323.6)	ELISA	Chimeric antibody (hamster/human)
TAB-225LC-F(E)	Anti-Human CD40LG Recombinant Antibody Fab Fragment (YMF323.6)	ELISA	Chimeric antibody (hamster/human)

CAT	Product Name	Application
TAB-213LC-F(E)	Human Anti-CD40LG Recombinant Antibody; Fab Fragment (TAB-213LC-F(E))	FC, ELISA, RBA
TAB-214LC-F(E)	Human Anti-CD40LG Recombinant Antibody; Fab Fragment (TAB-214LC-F(E))	FC, ELISA, RBA
TAB-215LC-F(E)	Human Anti-CD40LG Recombinant Antibody; Fab Fragment (TAB-215LC-F(E))	FC, ELISA, RBA
TAB-216LC-F(E)	Human Anti-CD40LG Recombinant Antibody; Fab Fragment (TAB-216LC-F(E))	FC, ELISA, RBA
TAB-217LC-F(E)	Human Anti-CD40LG Recombinant Antibody; Fab Fragment (TAB-217LC-F(E))	FC, ELISA, RBA

CAT	Product Name	Application	Type
MOB-0503CT	Mouse Anti-CD40LG Recombinant Antibody (clone 3C20)	ELISA, WB	Mouse IgG1
HPAB-0179-YC	Human Anti-CD40LG Recombinant Antibody (HPAB-0179-YC)	ELISA	Human IgG1
HPAB-0744LY	Human Anti-CD40LG Recombinant Antibody (HPAB-0744LY)	Inhib	Human IgG
VS3-XY339	Mouse Anti-CD40LG Recombinant Antibody, FITC (clone 4AM91)	FC, IF	Mouse IgG1
VS3-XY340	Mouse Anti-CD40LG Recombinant Antibody, PE (clone 4AM91)	FC, IF	Mouse IgG1

CAT	Product Name	Application	Type
NEUT-368CQ	Mouse Anti-CD40LG Recombinant Antibody (clone 24-31)	FC, Block, IF	Mouse IgG1, κ
NEUT-375CQ	Hamster Anti-CD40LG Recombinant Antibody (clone MR1)	IHC-Fr, FC, IP, Block	Hamster IgG1, κ
NEUT-377CQ	Hamster Anti-CD40LG Recombinant Antibody (clone MAB0820)	Block, FC, IHC-Fr	Hamster IgG

CAT	Product Name	Application	Type
NEUT-369CQ	Mouse Anti-CD40LG Recombinant Antibody (clone CBL300)	FC, IHC, CyTOF, Neut, WB	Mouse IgG2b
NEUT-370CQ	Mouse Anti-CD40LG Recombinant Antibody (clone LL2)	Neut, ELISA, FC, FuncS, IF	Mouse IgG1
NEUT-371CQ	Mouse Anti-CD40LG Recombinant Antibody (clone LL48)	Neut, FuncS, IF	Mouse IgG2a
NEUT-372CQ	Mouse Anti-CD40LG Recombinant Antibody (NEUT-372CQ)	Neut	Mouse IgG2b
NEUT-374CQ	Rat Anti-CD40LG Recombinant Antibody (clone CBL719)	FC, CyTOF, Neut	Rat IgG2a

CAT	Product Name	Application	Type
MOR-0561	Hi-Affi™ Rabbit Anti-CD40LG Recombinant Antibody (clone DS561AB)	WB, FC	Rabbit IgG
MOR-0562	Hi-Affi™ Rabbit Anti-CD40LG Recombinant Antibody (clone DS562AB)	ELISA	Rabbit IgG

CAT	Product Name	Application	Type
EPAF-0610LC	Mouse Anti-CD40LG Recombinant Antibody (clone h5c8)	ELISA	Mouse IgG1

CAT	Product Name	Application	Type
NS-022CN	Human Anti-CD40LG Recombinant Antibody (NS-022CN)	ELISA, FC	Human IgG
NS-022CN-F(E)	Human Anti-CD40LG Recombinant Antibody; Fab Fragment (NS-022CN-F(E))	ELISA, FC	Human Fab
NS-022CN-S(P)	Human Anti-CD40LG Recombinant Antibody; scFv Fragment (NS-022CN-S(P))	ELISA, FC	Human scFv

CAT	Product Name	Application	Type
AFC-TAB-876	Afuco™ Anti-CD40LG ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-876)	ELISA, FC, IP, FuncS, IF, Neut	ADCC enhanced antibody

CAT	Product Name	Application	Type
VS13-YC164	CytoStream™ Rabbit Anti-CD40LG Recombinant Antibody (VS13-YC164)	WB, ICC, IF, IHC-P, FC	Rabbit IgG

CAT	Product Name	Application	Type
VS-0425-FY79	Human Anti-CD40LG (clone YMF323.6) scFv-Fc Chimera	FC, ELISA, IHC	Human IgG1, scFv-Fc

CAT	Product Name	Application	Type
VS-0425-YC389	Recombinant Anti-CD40LG Vesicular Antibody, EV Displayed (VS-0425-YC389)	ELISA, FC, Neut, Cell-uptake

CAT	Product Name	Application	Type
VS-0525-XY1182	Anti-CD40LG Immunohistochemistry Kit	IHC
VS-0525-XY1183	Anti-Mouse CD40LG Immunohistochemistry Kit	IHC

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