Rabbit Anti-CTLA4 Recombinant Antibody (clone R05-6K5)

Name: Rabbit Anti-CTLA4 Recombinant Antibody (clone R05-6K5)
SKU: VS3-XY3326
Rating: 5 (1 reviews)

CAT#: VS3-XY3326

This is a recombinant rabbit antibody targeting the CTLA4 (Cytotoxic T-lymphocyte associated protein 4). It recognizes and binds to human CTLA4. It also has cross-reactivity against mouse and rat CTLA4. It has been reported for use in Western Blot, Immunocytochemistry or Immunofluorescence. The recommended dilutions of Western Blot, Immunofluorescence is 1/500-1/1000 and 1/50-1/200, respectively.

Gene Expression

RNA Expression Figure 1 RNA cell line category: Cell line enhanced (Karpas-707, SK-MEL-30, U-266/70, U-266/84)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000163599-CTLA4

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Specifications

Host Species
Rabbit

Type
Rabbit IgG

Specificity
Human, Mouse and Rat CTLA4

Species Reactivity
Human, Mouse, Rat

Clone
R05-6K5

Applications
WB, ICC, IF

Related Disease
Celiac Disease 3

Product Property

Clonality
Monoclonal

Aggregation
< 5%

Format
Liquid

Buffer
PBS (pH 7.4), 150 mM NaCl and 50% glycerol

Preservative
0.02% sodium azide

Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Shipping
Ice packs

Applications

Application Notes
WB: 1/500-1/1000
IF: 1/50-1/200

Target

Alternative Names
CD; GSE; GRD4; ALPS5; CD152; CTLA-4; IDDM12; CELIAC3

Gene ID
1493

UniProt ID
P16410

Long Name
Cytotoxic T-lymphocyte associated protein 4

Cellular Localization
Cell membrane

Post Translation Modifications
N-glycosylation is important for dimerization. (P16410-CTLA4_HUMAN)
Phosphorylation at Tyr-201 prevents binding to the AP-2 adapter complex, blocks endocytosis, and leads to retention of CTLA4 on the cell surface. (P16410-CTLA4_HUMAN)
Glycosylation at Asn113 and Asn145 (NX_P16410 [NX_P16410-1])
Modification sites at PhosphoSitePlus (P16410)
Glycosylation from GlyGen (P16410) 2 sites

Protein Refseq
NP_001032720.1

Function
Inhibitory receptor acting as a major negative regulator of T-cell responses.
The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28.

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Related Diseases

Rheumatoid Arthritis

Downloadable Resources

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Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

Datasheet - VS3-XY3326.pdf

MSDS

MSDS - VS3-XY3326.pdf

COA

Certificate of Analysis Lookup

To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.

Lot Number:

Protocol & Troubleshooting

Immunofluorescence (IF)

We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.

Isotype Control

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Recommended Dilution Buffer

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Secondary Antibody

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