Rabbit Anti-CTLA4 Recombinant Antibody (clone R05-6K5) (CAT#: VS3-XY3326)
This is a recombinant rabbit antibody targeting the CTLA4 (Cytotoxic T-lymphocyte associated protein 4). It recognizes and binds to human CTLA4. It also has cross-reactivity against mouse and rat CTLA4. It has been reported for use in Western Blot, Immunocytochemistry or Immunofluorescence. The recommended dilutions of Western Blot, Immunofluorescence is 1/500-1/1000 and 1/50-1/200, respectively.
Specific Inquiry
RNA Expression
Figure 1 RNA cell line category: Cell line enhanced (Karpas-707, SK-MEL-30, U-266/70, U-266/84)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000163599-CTLA4
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000163599-CTLA4
Figure 1 RNA cell line category: Cell line enhanced (Karpas-707, SK-MEL-30, U-266/70, U-266/84)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000163599-CTLA4
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000163599-CTLA4
Specifications
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human, Mouse and Rat CTLA4
- Species Reactivity
- Human, Mouse, Rat
- Clone
- R05-6K5
- Applications
- WB, ICC, IF
- Related Disease
- Celiac Disease 3
Product Property
- Clonality
- Monoclonal
- Aggregation
- < 5%
- Format
- Liquid
- Buffer
- PBS (pH 7.4), 150 mM NaCl and 50% glycerol
- Preservative
- 0.02% sodium azide
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- WB: 1/500-1/1000
IF: 1/50-1/200
Target
- Alternative Names
- CD; GSE; GRD4; ALPS5; CD152; CTLA-4; IDDM12; CELIAC3
- Gene ID
- 1493
- UniProt ID
- P16410
- Long Name
- Cytotoxic T-lymphocyte associated protein 4
- Cellular Localization
- Cell membrane
- Post Translation Modifications
- N-glycosylation is important for dimerization. (P16410-CTLA4_HUMAN)
Phosphorylation at Tyr-201 prevents binding to the AP-2 adapter complex, blocks endocytosis, and leads to retention of CTLA4 on the cell surface. (P16410-CTLA4_HUMAN)
Glycosylation at Asn113 and Asn145 (NX_P16410 [NX_P16410-1])
Modification sites at PhosphoSitePlus (P16410)
Glycosylation from GlyGen (P16410) 2 sites
- Protein Refseq
- NP_001032720.1
- Function
- Inhibitory receptor acting as a major negative regulator of T-cell responses.
The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28.
Recommended Products
Isotype Control
Recommended Dilution Buffer
Secondary Antibody
Related Resources
Rheumatoid Arthritis
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
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ScFv-Fc Chimera Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-067 | Anti-Human CTLA4 Recombinant Antibody (TAB-067) | WB, FuncS, IF, Neut, ELISA, FC, IP | IgG1 - kappa |
| TAB-206 | Anti-Human CTLA4 Recombinant Antibody (Ticilimumab (Tremelimumab)) | WB, IF, IP, Neut, FuncS, ELISA, FC | IgG2 |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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