Mouse Anti-GSK3B Recombinant Antibody (VS3-FY2725) (CAT#: VS3-FY2725)

• Type
• Mouse IgG

• Specificity
• Glycogen synthase kinase 3 beta of human, mouse and rat origins

• Conjugate
• Unconjugated, FITC

• Related Disease
• Parkinson disease and Alzheimer disease

• Clonality
• Monoclonal Antibody

• Format
• Liquid

• Concentration
• Please refer to the vial label for the specific concentration.

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.

• Alternative Names
• Glycogen Synthase Kinase 3 Beta; EC 2.7.11.26; Serine/Threonine-Protein Kinase GSK3B; EC 2.7.11.1; GSK-3 Beta; EC 2.7.11

• Gene ID
• 2932

• UniProt ID
• P49841

• Sequence Similarities
• Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.

• Cellular Localization
• Cytoplasm
  Nucleus
  Cell membrane

• Post Translation Modifications
• Phosphorylated by AKT1 and ILK1.
  Upon insulin-mediated signaling, the activated PKB/AKT1 protein kinase phosphorylates and deactivates GSK3B, resulting in the dephosphorylation and activation of GYS1.
  Activated by phosphorylation at Tyr-216.
  Inactivated by phosphorylation at Ser-9.
  Phosphorylated in a circadian manner in the hippocampus (By similarity).
  Mono-ADP-ribosylation by PARP10 negatively regulates kinase activity.
  Modification sites at PhosphoSitePlus
  Modification sites at neXtProt
  Glycosylation from GlyGen 3 sites, 1 O-linked glycan (3 sites)

• Protein Refseq
• XP_006713673.1; XP_054202359.1; NP_001139628.1; NP_001341525.1; NP_002084.2

• Function
• Requires primed phosphorylation of the majority of its substrates (PubMed:11430833, 16484495).
  In skeletal muscle, contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis (PubMed:8397507).
  May also mediate the development of insulin resistance by regulating activation of transcription factors (PubMed:8397507).
  Regulates protein synthesis by controlling the activity of initiation factor 2B (EIF2BE/EIF2B5) in the same manner as glycogen synthase.

Secondary Antibody

• 2ND-040CQ
• Goat Anti-Mouse IgG (H&L) Antibody

Isotype Control

• MRO-A1591-YJ
• Mouse IgG Isotype control, Polyclonal

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