Mouse Anti-GSK3B Recombinant Antibody (VS3-FY2725)
CAT#: VS3-FY2725
The anti-GSK3B antibody has been genetically engineered to specifically target human GSK3 beta protein. It shows capability of cross-reacting with mouse and rat. This monoclonal antibody proves valuable in disease research related to Parkinson disease and Alzheimer disease.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/28017/if_selected.jpg
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| Sub Cat | Host Animal | Species Reactivity | Application | Application Notes | Size | Conjugation | Endotoxin | Purity | Fc Engineering | |
| VS3-FY2782 | Mouse | Human, Mouse, Rat | WB, ICC, FC, IP |
Immunoprecipitation: 1/20 Western Blot: 1/500-1/1000 Immunocytochemistry: 1/50-1/200 Flow cytometry: 1/50-1/100 |
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| VS3-FY2726 | Rabbit | Human, Rat, Hamster | WB, IHC |
Western Blot: 1/500-1/1000 Immunohistochemistry: 1/50-1/100 |
Specifications
- Type
- Mouse IgG
- Specificity
- Glycogen synthase kinase 3 beta of human, mouse and rat origins
- Conjugate
- Unconjugated, FITC
- Related Disease
- Parkinson disease and Alzheimer disease
Product Property
- Clonality
- Monoclonal Antibody
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- Glycogen Synthase Kinase 3 Beta; EC 2.7.11.26; Serine/Threonine-Protein Kinase GSK3B; EC 2.7.11.1; GSK-3 Beta; EC 2.7.11
- Gene ID
- 2932
- UniProt ID
- P49841
- Sequence Similarities
- Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.
- Cellular Localization
- Cytoplasm
Nucleus
Cell membrane
- Post Translation Modifications
- Phosphorylated by AKT1 and ILK1.
Upon insulin-mediated signaling, the activated PKB/AKT1 protein kinase phosphorylates and deactivates GSK3B, resulting in the dephosphorylation and activation of GYS1.
Activated by phosphorylation at Tyr-216.
Inactivated by phosphorylation at Ser-9.
Phosphorylated in a circadian manner in the hippocampus (By similarity).
Mono-ADP-ribosylation by PARP10 negatively regulates kinase activity.
Modification sites at PhosphoSitePlus
Modification sites at neXtProt
Glycosylation from GlyGen 3 sites, 1 O-linked glycan (3 sites)
- Protein Refseq
- XP_006713673.1; XP_054202359.1; NP_001139628.1; NP_001341525.1; NP_002084.2
- Function
- Requires primed phosphorylation of the majority of its substrates (PubMed:11430833, 16484495).
In skeletal muscle, contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis (PubMed:8397507).
May also mediate the development of insulin resistance by regulating activation of transcription factors (PubMed:8397507).
Regulates protein synthesis by controlling the activity of initiation factor 2B (EIF2BE/EIF2B5) in the same manner as glycogen synthase.
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Related Signaling Pathways
BCR Signaling Pathway
Canonical Wnt Signaling Pathway
ErbB Signaling Pathway
JAK-STAT Signaling Pathway
mTOR Signaling Pathway
Non-Canonical Wnt Signaling Pathway
PI3K-Akt Signaling Pathway
Related Diseases
Breast Cancer
Endometrial Cancer
Pancreatic Cancer
Prostate Cancer
Throid Cancer
Hepatocellular Carcinoma
Insulin Resistance
Cushing Syndrome
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Secondary Antibody
- CAT
- Product Name
Isotype Control
- CAT
- Product Name
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