Rat Anti-IL18 Recombinant Antibody (clone 14B7) (CAT#: HPAB-0064-YJ)
This product is a recombinant rat antibody that recognizes human IL-18. Mab 14B7 is useful in the treatment and diagnosis of conditions mediated by IL-18. It may function in the treatment of inflammatory bowel disease, arthritis, psoriatics.
Specific Inquiry
IHC
Figure 1 Human atherosclerotic lesions express IL-18.
Serial cryostat sections of frozen specimens of nonatherosclerotic aorta (Normal) were analyzed by either immunohistochemistry, using mouse anti–human IL-18.
Gerdes, N., Sukhova, G. K., Libby, P., Reynolds, R. S., Young, J. L., & Schönbeck, U. (2002). Expression of interleukin (IL)-18 and functional IL-18 receptor on human vascular endothelial cells, smooth muscle cells, and macrophages: implications for atherogenesis. The Journal of experimental medicine, 195(2), 245-257.
IF
Figure 2 Differential expression of IL-18 in ECs.
Analysis of three atheroma from different individuals showed similar results.
Gerdes, N., Sukhova, G. K., Libby, P., Reynolds, R. S., Young, J. L., & Schönbeck, U. (2002). Expression of interleukin (IL)-18 and functional IL-18 receptor on human vascular endothelial cells, smooth muscle cells, and macrophages: implications for atherogenesis. The Journal of experimental medicine, 195(2), 245-257.
WB
Figure 3 Human atherosclerotic lesions contain immunoreactive IL-18.
Western blot analysis using an anti–IL-18.
Gerdes, N., Sukhova, G. K., Libby, P., Reynolds, R. S., Young, J. L., & Schönbeck, U. (2002). Expression of interleukin (IL)-18 and functional IL-18 receptor on human vascular endothelial cells, smooth muscle cells, and macrophages: implications for atherogenesis. The Journal of experimental medicine, 195(2), 245-257.
FC
Figure 4 IL-1 was studied for the expression of IL-18 by FACS analysis.
Similar results were obtained in three independent experiments using cells of different donors.
Gerdes, N., Sukhova, G. K., Libby, P., Reynolds, R. S., Young, J. L., & Schönbeck, U. (2002). Expression of interleukin (IL)-18 and functional IL-18 receptor on human vascular endothelial cells, smooth muscle cells, and macrophages: implications for atherogenesis. The Journal of experimental medicine, 195(2), 245-257.
Specifications
- Immunogen
- Recombinant IL-18
- Host Species
- Rat
- Type
- Rat IgG1, κ
- Specificity
- Human IL18
- Species Reactivity
- Human
- Clone
- 14B7
- Applications
- IF, FC, IHC, WB
- Related Disease
- Inflammatory Bowel Disease, Arthritis, Psoriatics
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- The IL18 antibody has been reported in applications of Western Blot, Flow Cytometry, Immunofluorescence, Immunohistochemistry.
Target
- Alternative Names
- Interleukin 18; IGIF; IL-18; IL-1g; IL1F4; IFN-gamma-inducing factor; IL-1 gamma; iboctadekin; interleukin 18 (interferon-gamma-inducing factor); interleukin-1 gamma; 14B7; MAb 14B7
- Gene ID
- 3606
- UniProt ID
- Q14116
Related Resources
Inflammatory Bowel Diseases
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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See other products for "Clone 14B7"
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scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBL-602 | Human Anti-IL18 Recombinant Antibody (clone YC127); scFv Fragment | WB, ELISA, FuncS | Human scFv |
| HPAB-0649-CN-S(P) | Human Anti-IL18 Recombinant Antibody; scFv Fragment (HPAB-0649-CN-S(P)) | ELISA, Neut | Humanized scFv |
| HPAB-0650-CN-S(P) | Rat Anti-IL18 Recombinant Antibody; scFv Fragment (HPAB-0650-CN-S(P)) | ELISA, Neut | Rat scFv |
| FAMAB-0041JF-S(P) | Human Anti-IL18 Recombinant Antibody (clone h18-108); scFv Fragment | IB, FC, ELISA, FuncS | Human scFv |
| HPAB-1546WJ-S(P) | Human Anti-IL18 Recombinant Antibody; scFv Fragment (clone #125-2HmAb) | ELISA, WB | Human scFv |
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0373CL | Human Anti-IL18 Recombinant Antibody (TAB-0373CL) | ELISA, FuncS, Inhib | Human IgG |
| TAB-0374CL | Human Anti-IL18 Recombinant Antibody (TAB-0374CL) | ELISA, FuncS, Inhib | Human IgG |
| TAB-0373CL-S(P) | Human Anti-IL18 Recombinant Antibody; scFv Fragment (TAB-0373CL-S(P)) | ELISA, FuncS, Inhib | Human scFv |
| TAB-0374CL-S(P) | Human Anti-IL18 Recombinant Antibody; scFv Fragment (TAB-0374CL-S(P)) | ELISA, FuncS, Inhib | Human scFv |
| TAB-0373CL-F(E) | Human Anti-IL18 Recombinant Antibody; Fab Fragment (TAB-0373CL-F(E)) | ELISA, FuncS, Inhib | Human Fab |
Chicken IgY Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0290MZ | Chicken Anti-Interleukin-18 Polyclonal IgY | Indirect ELISA, WB | Chicken antibody |
Neutralizing Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1238CQ | Rabbit Anti-IL18 Recombinant Antibody (clone 1072F) | Neut | Rabbit IgG |
| NEUT-1239CQ | Rat Anti-Il18 Recombinant Antibody (clone 39-3F) | Neut, WB | Rat IgG2a |
| NEUT-1240CQ | Mouse Anti-IL18 Recombinant Antibody (clone CBL670) | Neut | Mouse IgG2a |
| NEUT-1241CQ | Rat Anti-Il18 Recombinant Antibody (clone YIGIF74-1G7) | Neut | Rat IgG2a |
| NEUT-1242CQ | Rat Anti-Il18 Recombinant Antibody (clone 93-10C) | IP, Neut | Rat IgG1 |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-4248 | Rabbit Anti-IL18 Recombinant Antibody (clone SI327DS) | ELISA | Rabbit IgG |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0229-CN-F(E) | Human Anti-IL18 Recombinant Antibody (clone 1I1G); Fab Fragment | WB, ELISA | Human Fab |
| FAMAB-0230-CN-F(E) | Human Anti-IL18 Recombinant Antibody (clone 3I1E); Fab Fragment | WB, ELISA | Human Fab |
| FAMAB-0231-CN-F(E) | Human Anti-IL18 Recombinant Antibody (clone 4I3E); Fab Fragment | WB, ELISA | Human Fab |
| HPAB-0649-CN-F(E) | Human Anti-IL18 Recombinant Antibody; Fab Fragment (HPAB-0649-CN-F(E)) | ELISA, Neut | Humanized Fab |
| HPAB-0650-CN-F(E) | Human Anti-IL18 Recombinant Antibody; Fab Fragment (HPAB-0650-CN-F(E)) | ELISA, Neut | Chimeric (rat/human) Fab |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0649-CN | Human Anti-IL18 Recombinant Antibody (HPAB-0649-CN) | ELISA, Neut | Humanized IgG1, κ |
| HPAB-0650-CN | Human Anti-IL18 Recombinant Antibody (HPAB-0650-CN) | ELISA, Neut | Chimeric (rat/human) IgG1, κ |
| HPAB-1273LY | Human Anti-IL18 Recombinant Antibody (HPAB-1273LY) | IHC, WB | Human IgG |
| HPAB-1274LY | Human Anti-IL18 Recombinant Antibody (HPAB-1274LY) | IHC, WB, IF | Human IgG |
| HPAB-1275LY | Human Anti-IL18 Recombinant Antibody (HPAB-1275LY) | Inhib, WB, IHC, ELISA, FC | Human IgG |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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