Human Anti-KDR Recombinant Antibody (clone PCABHL3); Fab Fragment

Name: Human Anti-KDR Recombinant Antibody (clone PCABHL3); Fab Fragment
SKU: HPAB-M0127-YC-F(E)
Rating: 5 (1 reviews)

CAT#: HPAB-M0127-YC-F(E)

Provided is a vascular endothelial growth factor receptor (VEGFR2) resisting monoclonal antibody. The monoclonal antibody can be specifically combined the VEGFR2 and can block combination of a VEGF (vascular endothelial growth factor) and the VEGFR2; cell biology activity analysis shows that the VEGFR2 has remarkable inhibiting effect on VEGF-induced HUVEC (human umbilical vein endothelial cells); therefore, the VEGFR2 resisting monoclonal antibody can be applied to preparation of drugs capable of blocking the VEGFR2 to serve as a new anti-tumor drug.

Gene Expression

Subcellular Location Figure 1 IF staining of human cell line HEL

Immunofluorescent staining of human cell line HEL shows localization to nuclear membrane & vesicles.

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/73577/1825_D8_31_cr5ac340707076b_selected.jpg

Normal Tissue Figure 2 Placenta

High expression

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4028/11467_A_2_7_val_selected.jpg

Normal Tissue Figure 3 Colon

Endothelial cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4028/11467_A_8_3.jpg

Normal Tissue Figure 4 Kidney

Cells in glomeruli Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4028/11467_A_7_5.jpg

Normal Tissue Figure 5 Testis

Leydig cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4028/11467_A_6_6.jpg

RNA Expression Figure 6 RNA cell line category: Group enriched (HUVEC TERT2, TIME)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000128052-KDR

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Specifications

Host Species
Human

Derivation
Humanized

Type
Humanized Fab

Specificity
Human KDR

Species Reactivity
Human

Clone
PCABHL3

Applications
ELISA, Inhib

Product Property

Purity
>95% as determined by SDS-PAGE and HPLC analysis

Buffer
PBS

Preservative
No preservatives

Storage
Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Alternative Names
Kinase Insert Domain Receptor; Kinase Insert Domain Receptor (A Type III Receptor Tyrosine Kinase); Vascular Endothelial Growth Factor Receptor 2; Protein-Tyrosine Kinase Receptor Flk-1; Fetal Liver Kinase 1; EC 2.7.10.1; VEGFR2; FLK1; Tyrosine Kinase Growth Factor Receptor;

Gene ID
3791

UniProt ID
P35968

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Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

Datasheet - HPAB-M0127-YC-F(E).pdf

MSDS

MSDS - HPAB-M0127-YC-F(E).pdf

COA

Certificate of Analysis Lookup

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