Human Anti-PCSK9 Recombinant Antibody (clone 5E11) (CAT#: PABC-505)
This product is a recombinant Human antibody that can recognize PCSK9. The antibody can recognize epitopes within the HSPG binding domain.
Specific Inquiry
IP
Figure 1 mAbs were tested by IP.
Fifteen mAbs specifically precipitated radioactive-labeled PCSK9.
Gustafsen, C., Olsen, D., Vilstrup, J., Lund, S., Reinhardt, A., Wellner, N., ... & Seeberger, P. H. (2017). Heparan sulfate proteoglycans present PCSK9 to the LDL receptor. Nature communications, 8(1), 503.
Inhib
Figure 2 Co-injection of PCSK9 (10 µg) with mAb 5E11 (50 µg) protects the LDLR from degradation (control n = 4, PCSK9 n = 7, PCSK9/mAb 5E11 n = 6).
Representative blot is shown.
Gustafsen, C., Olsen, D., Vilstrup, J., Lund, S., Reinhardt, A., Wellner, N., ... & Seeberger, P. H. (2017). Heparan sulfate proteoglycans present PCSK9 to the LDL receptor. Nature communications, 8(1), 503.
Specifications
- Immunogen
- DNA encoding chimeric rat PCSK9 containing the human HSPG-binding domain
- Host Species
- Human
- Type
- Human IgG1, λ
- Specificity
- Human PCSK9
- Species Reactivity
- Human
- Clone
- 5E11
- Applications
- WB, IP, ELISA, IF, Inhib
- Related Disease
- Coronary artery disease (CAD)
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- This antibody has been reported for use in Western Blot, Immunoprecipitation, Enzyme-linked Immunosorbent Assay, Immunofluorescence and Inhibition. It's recommended that the optimal antibody concentration, dilution, incubition time, etc. be carefully titrated in specific assays.
Target
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABZ-101 | Human Anti-PCSK9 Recombinant Antibody (clone 1D05) | ELISA, WB, Neut | Human IgG2 |
| HPAB-0234-YC | Mouse Anti-PCSK9 Recombinant Antibody (HPAB-0234-YC) | ELISA, FuncS | Mouse IgG |
| HPAB-0051-FY | Human Anti-PCSK9 Recombinant Antibody (HPAB-0051-FY) | Inhib, ELISA | Human IgG2, κ |
| HPAB-0141-FY | Human Anti-PCSK9 Recombinant Antibody (clone YW508.20.33) | FuncS, In vivo | Human IgG1 |
| HPAB-0152-FY | Mouse Anti-PCSK9 Recombinant Antibody (HPAB-0152-FY) | ELISA | Mouse IgG, κ |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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