Human Anti-PCSK9 Recombinant Antibody (clone 5E11)
CAT#: PABC-505
This product is a recombinant Human antibody that can recognize PCSK9. The antibody can recognize epitopes within the HSPG binding domain.
Published Data
Gene Expression
IP
Figure 1 mAbs were tested by IP.
Fifteen mAbs specifically precipitated radioactive-labeled PCSK9.
Gustafsen, C., Olsen, D., Vilstrup, J., Lund, S., Reinhardt, A., Wellner, N., ... & Seeberger, P. H. (2017). Heparan sulfate proteoglycans present PCSK9 to the LDL receptor. Nature communications, 8(1), 503.
Inhib
Figure 2 Co-injection of PCSK9 (10 µg) with mAb 5E11 (50 µg) protects the LDLR from degradation (control n = 4, PCSK9 n = 7, PCSK9/mAb 5E11 n = 6).
Representative blot is shown.
Gustafsen, C., Olsen, D., Vilstrup, J., Lund, S., Reinhardt, A., Wellner, N., ... & Seeberger, P. H. (2017). Heparan sulfate proteoglycans present PCSK9 to the LDL receptor. Nature communications, 8(1), 503.
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RNA Expression
Figure 1 RNA cell line category: Cell line enhanced (A-431, CACO-2, HaCaT, HeLa, RPTEC TERT1)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000169174-PCSK9
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Specifications
- Immunogen
- DNA encoding chimeric rat PCSK9 containing the human HSPG-binding domain
- Host Species
- Human
- Type
- Human IgG1, λ
- Specificity
- Human PCSK9
- Species Reactivity
- Human
- Clone
- 5E11
- Applications
- WB, IP, ELISA, IF, Inhib
- Related Disease
- Coronary artery disease (CAD)
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- This antibody has been reported for use in Western Blot, Immunoprecipitation, Enzyme-linked Immunosorbent Assay, Immunofluorescence and Inhibition. It's recommended that the optimal antibody concentration, dilution, incubition time, etc. be carefully titrated in specific assays.
Target
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
See other products for "Clone 5E11"
- CAT
- Product Name
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| NABL-097 | Recombinant Anti-human PCSK9 VHH Single Domain Antibody | WB, ELISA, IHC, FC, FuncS | Llama VHH |
| TAB-0080CL-VHH | Anti-Human PCSK9 VHH Single Domain Antibody (TAB-0080CL-VHH) | FuncS, Inhib, FC, WB | Single domain antibody |
| TAB-0081CL-VHH | Anti-Human PCSK9 VHH Single Domain Antibody (TAB-0081CL-VHH) | FuncS, Inhib, FC, WB | Single domain antibody |
| TAB-0082CL-VHH | Anti-Human PCSK9 VHH Single Domain Antibody (TAB-0082CL-VHH) | FuncS, Inhib, FC, WB | Single domain antibody |
| TAB-0083CL-VHH | Anti-Human PCSK9 VHH Single Domain Antibody (TAB-0083CL-VHH) | FuncS, Inhib, FC, WB | Single domain antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-H31 | Human Anti-PCSK9 Recombinant Antibody (TAB-H31) | FC, IP, ELISA, Neut, FuncS, IF, IHC | Human IgG2, λ |
| TAB-0953CL-S(P) | Human Anti-PCSK9 Recombinant Antibody; scFv Fragment (TAB-0953CL-S(P)) | ELISA | Human scFv |
| TAB-0954CL-S(P) | Human Anti-PCSK9 Recombinant Antibody; scFv Fragment (TAB-0954CL-S(P)) | WB | Human scFv |
| TAB-0955CL-S(P) | Mouse Anti-PCSK9 Recombinant Antibody; scFv Fragment (TAB-0955CL-S(P)) | WB | Mouse scFv |
| TAB-0959CL-S(P) | Human Anti-PCSK9 Recombinant Antibody; scFv Fragment (TAB-0959CL-S(P)) | ELISA, FC | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-H59 | Anti-Human PCSK9 Recombinant Antibody (TAB-H59) | Neut, ELISA, IF, IP, FuncS, FC, ICC | IgG2 - kappa |
| TAB-764CL | Human Anti-PCSK9 Recombinant Antibody (TAB-764CL) | ELISA | Human IgG |
| TAB-0020CL-S(P) | Anti-Human PCSK9 Recombinant Antibody scFv Fragment (LPD1282/LPD1462 {i.e., antibody 1 F11)) | LDL-c uptake assay | Humanized Antibody |
| TAB-0957CL-S(P) | Anti-Human PCSK9 Recombinant Antibody scFv Fragment (h7F8) | ELISA | Humanized antibody |
| TAB-0958CL-S(P) | Anti-Human PCSK9 Recombinant Antibody scFv Fragment (h7F8ml2) | ELISA | Humanized antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBL-294 | Human Anti-PCSK9 Recombinant Antibody (clone mAb1); Fab Fragment | WB, Block, FuncS | Human Fab |
| HPAB-0309-FY-F(E) | Human Anti-PCSK9 Recombinant Antibody (clone 8F5); Fab Fragment | ELISA | Human Fab |
| HPAB-0310-FY-F(E) | Human Anti-PCSK9 Recombinant Antibody (clone 3D1); Fab Fragment | ELISA | Human Fab |
| HPAB-0311-FY-F(E) | Human Anti-PCSK9 Recombinant Antibody (clone 7c4); Fab Fragment | ELISA | Human Fab |
| HPAB-0312-FY-F(E) | Human Anti-PCSK9 Recombinant Antibody (clone 5C2); Fab Fragment | ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABZ-101 | Human Anti-PCSK9 Recombinant Antibody (clone 1D05) | ELISA, WB, Neut | Human IgG2 |
| HPAB-0810-CN | Human Anti-PCSK9 Recombinant Antibody (HPAB-0810-CN) | ELISA | Human IgG |
| HPAB-1373-FY | Human Anti-PCSK9 Recombinant Antibody (HPAB-1373-FY) | ELISA | Human IgG |
| HPAB-1374-FY | Human Anti-PCSK9 Recombinant Antibody (HPAB-1374-FY) | ELISA | Human IgG |
| HPAB-1375-FY | Human Anti-PCSK9 Recombinant Antibody (HPAB-1375-FY) | ELISA | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBZ-101 | Human Anti-PCSK9 Recombinant Antibody (clone 1D05); scFv Fragment | ELISA, WB, Neut | Human scFv |
| HPAB-M0312-YC-S(P) | Human Anti-PCSK9 Recombinant Antibody; scFv Fragment (HPAB-M0312-YC-S(P)) | ELISA, Block | Human scFv |
| HPAB-1373-FY-F(E) | Human Anti-PCSK9 Recombinant Antibody; Fab Fragment (HPAB-1373-FY-F(E)) | ELISA | Human Fab |
| HPAB-1374-FY-F(E) | Human Anti-PCSK9 Recombinant Antibody; Fab Fragment (HPAB-1374-FY-F(E)) | ELISA | Human Fab |
| HPAB-1375-FY-F(E) | Human Anti-PCSK9 Recombinant Antibody; Fab Fragment (HPAB-1375-FY-F(E)) | ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0956CL | Anti-Human PCSK9 Recombinant Antibody (m7F8) | ELISA | |
| TAB-0960CL | Anti-Human PCSK9 Recombinant Antibody (Ab1) | ELISA | Rabbit mAb |
| TAB-0956CL-S(P) | Anti-Human PCSK9 Recombinant Antibody scFv Fragment (m7F8) | ELISA | |
| TAB-0960CL-S(P) | Anti-Human PCSK9 Recombinant Antibody scFv Fragment (Ab1) | ELISA | Rabbit mAb |
| TAB-0956CL-F(E) | Anti-Human PCSK9 Recombinant Antibody Fab Fragment (m7F8) | ELISA |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1826CQ | Recombinant Human Anti-PCSK9 Antibody, Unconjugated | Neut | IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2618 | Hi-Affi™ Recombinant Rabbit Anti-PCSK9 Monoclonal Antibody (DS2618AB) | WB | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-758 | Afuco™ Anti-PCSK9 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-758) | ELISA, FC, IP, FuncS, IF, Neut | ADCC enhanced antibody |
| AFC-TAB-H10 | Afuco™ Anti-PCSK9 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-H10) | FC, IP, ELISA, Neut, FuncS | ADCC enhanced antibody |
| AFC-TAB-H59 | Afuco™ Anti-PCSK9 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-H59) | Neut, ELISA, IF, IP, FuncS, FC | ADCC enhanced antibody |
| AFC-TAB-H31 | Afuco™ Anti-PCSK9 Recombinant Antibody (AFC-TAB-H31), ADCC Enhanced | FC, IP, ELISA, Neut, FuncS, IF | Human IgG1, λ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0424-XY208 | AbPlus™ Anti-PCSK9 Magnetic Beads (VS-0424-XY208) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-FY208 | Human Anti-PCSK9 scFv-Fc Chimera (VS-0325-FY208) | WB, Block | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY5250 | Anti-PCSK9 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-YC142 | Recombinant Anti-PCSK9 (AA 31-152 x AA 213-219) Biparatopic Antibody, Tandem scFv (Clone 6E2 x Clone 3D5) | ELISA | Tandem scFv |
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