Mouse Anti-SNCA Monoclonal Antibody (clone 2B2D1) (CAT#: VS7-0425-WR897)

• Immunogen
• Recombinant human SNCA fragment expressed in E. Coli.

• Host Species
• Mouse

• Type
• Mouse IgG1

• Specificity
• Human SNCA

• Species Reactivity
• Human

• Clone
• 2B2D1

• Molecule Class
• Alpha-Synuclein

• Applications
• IHC

• Conjugate
• Unconjugated

• Related Disease
• Parkinson disease 1, autosomal dominant (PARK1); Parkinson disease 4, autosomal dominant (PARK4); Dementia, Lewy body (DLB)

• Clonality
• Monoclonal

• Purity
• >95% as determined by SDS-PAGE and SEC-HPLC analysis, Ascitic fluid

• Format
• Liquid

• Concentration
• Please refer to the vial label for the specific concentration.

• Preservative
• 0.03% sodium azide

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

• Shipping
• Ice packs

• Application Notes
• Western Blot: 1:500 - 1:2000
  Immunohistochemistry-Paraffin: 1:200 - 1:1000
  Enzyme-linked Immunosorbent Assay: 1:10000

• Alternative Names
• SNCA; synuclein, alpha (non A4 component of amyloid precursor); PD1; NACP; PARK1; PARK4; alpha-synuclein; synuclein alpha-140; non A-beta component of AD amyloid

• Gene ID
• 6622

• UniProt ID
• P37840

• Long Name
• Synuclein Alpha

• Cellular Localization
• Amyloid; Cell projection; Cytoplasm; Membrane; Nucleus; Secreted; Synapse

• Post Translation Modifications
• Acetylation; Phosphoprotein; Ubl conjugation

• Protein Refseq
• NP_000336.1

• Function
• Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release (PubMed:20798282, PubMed:26442590, PubMed:28288128, PubMed:30404828).; Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores (PubMed:28288128, PubMed:30404828).; Mechanistically, acts by increasing local Ca2+ release from microdomains which is essential for the enhancement of ATP-induced exocytosis (PubMed:30404828).; Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5 (PubMed:20798282).; This chaperone activity is important to sustain normal SNARE-complex assembly during aging (PubMed:20798282).; Also plays a role in the regulation of the dopamine neurotransmission by associating with the dopamine transporter (DAT1) and thereby modulating its activity (PubMed:26442590).

Isotype Control

• MOB-065CQ
• Mouse IgG1 Isotype Control Antibody

Secondary Antibody

• 2RD-A1562-YJ
• Rabbit Anti-Mouse IgG1 Secondary antibody (Clone RM106)

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