Mouse Anti-TEK Recombinant Antibody (clone 12H8); Fab Fragment (CAT#: HPAB-S0139-YC-F(E))
Provided is an antagonist antibody which binds to Tie2 receptor. The antibody Fab Fragment can be used in inhibiting angiogenesis.
Specific Inquiry
Custom Production
We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.
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Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane & centriolar satellites.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/73265/1607_D9_2_selected.jpg
(Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane & centriolar satellites.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/73265/1607_D9_2_selected.jpg
Figure 2 IHC staining of human testis
(Immunohistochemical staining of human testis shows strong cytoplasmic positivity in cells of seminiferus ducts.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10359/ihc_selected.jpg
(Immunohistochemical staining of human testis shows strong cytoplasmic positivity in cells of seminiferus ducts.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10359/ihc_selected.jpg
Figure 3 IF staining of human cell line AF22
(Immunofluorescent staining of human cell line AF22 shows localization to plasma membrane & centriolar satellites.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/73265/1687_H4_1_red_green.jpg
(Immunofluorescent staining of human cell line AF22 shows localization to plasma membrane & centriolar satellites.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/73265/1687_H4_1_red_green.jpg
Figure 4 IF staining of human cell line BJ
(Immunofluorescent staining of human cell line BJ shows localization to plasma membrane & centriolar satellites.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/73265/1667_D9_1_red_green.jpg
(Immunofluorescent staining of human cell line BJ shows localization to plasma membrane & centriolar satellites.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/73265/1667_D9_1_red_green.jpg
Figure 5 Colon
(Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Peripheral nerve/ganglion
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10359/24108_A_8_3.jpg
(Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Peripheral nerve/ganglion
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10359/24108_A_8_3.jpg
Figure 6 Testis
(Elongated or late spermatids
Staining: High
Intensity: Strong
Quantity:>75%
Leydig cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Pachytene spermatocytes
Staining: High
Intensity: Strong
Quantity: 75%-25%
Round or early spermatids
Staining: High
Intensity: Strong
Quantity:>75%
Sertoli cells
Staining: Medium
Intensity: Moderate
Quantity:>75%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10359/24108_A_6_6.jpg
(Elongated or late spermatids
Staining: High
Intensity: Strong
Quantity:>75%
Leydig cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Pachytene spermatocytes
Staining: High
Intensity: Strong
Quantity: 75%-25%
Round or early spermatids
Staining: High
Intensity: Strong
Quantity:>75%
Sertoli cells
Staining: Medium
Intensity: Moderate
Quantity:>75%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10359/24108_A_6_6.jpg
Figure 7 RNA cell line category: Group enriched (HUVEC TERT2, NTERA-2, TIME)
(Cell lines ordered by descending RNA expression order.)
* https://v21.proteinatlas.org/ENSG00000120156-TEK
(Cell lines ordered by descending RNA expression order.)
* https://v21.proteinatlas.org/ENSG00000120156-TEK
Figure 7 RNA cell line category: Group enriched (HUVEC TERT2, NTERA-2, TIME)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000120156-TEK
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000120156-TEK
Specifications
- Immunogen
- Recombinant Tie2 extracellular domain-Fc fusion
- Host Species
- Mouse
- Type
- Mouse Fab
- Specificity
- Human TEK
- Species Reactivity
- Human
- Clone
- 12H8
- Applications
- ELISA, Antagonist
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- TEK Receptor Tyrosine Kinase; Tyrosine Kinase With Ig And EGF Homology Domains-2; Tunica Interna Endothelial Cell Kinase; Tyrosine-Protein Kinase Receptor TIE-2; Tyrosine-Protein Kinase Receptor TEK; TEK Tyrosine Kinase, Endothelial; Endothelial Tyrosine Kinase; EC 2.7.10.1; VMCM1; VMCM; TIE2
- Gene ID
- 7010
- UniProt ID
- Q02763
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| IAB-B064(A) | Recombinant Anti-human TEK Intrabody [(D-Arg)9] | PCA, Neut, FuncS | scFv-(D-Arg)9 |
| IAB-B064(G) | Recombinant Anti-human TEK Intrabody [+36 GFP] | WB, Neut, FuncS | scFv-(+36GFP) |
| IAB-B064(T) | Recombinant Anti-human TEK Intrabody [Tat] | ELISA, ICC, FuncS | scFv-Tat |
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