Anti-TGFB1 (clone 31G9) Recombinant Antibody Coupled Liposome (VS-1024-FY244)
CAT#: VS-1024-FY244
Anti-TGF-β antibody conjugated liposomes hold significant potential for targeted therapy in subcutaneous F9 teratocarcinoma tumors by selectively delivering therapeutic agents to tumor sites, thus enhancing treatment efficacy while minimizing systemic side effects. The liposome's design allows for improved uptake by cancer cells, leading to a more effective blockade of the TGF-β signaling pathway, which is crucial for tumor growth and progression. Additionally, the use of these liposomes could facilitate the induction of immune responses against the tumor, potentially improving overall patient outcomes. Research in this area may reveal novel strategies for overcoming resistance to traditional therapies, paving the way for more effective cancer treatment protocols.
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to cytosol & the Golgi apparatus.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/73356/1901_C17_1_selected.jpg
Subcellular Location and Protein Expression
Figure 2 IHC staining of human bone marrow
Immunohistochemical staining of human bone marrow shows strong cytoplasmic positivity in bone marrow poietic cells.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/361/ihc_selected.jpg
Subcellular Location and Protein Expression
Figure 3 IF staining of human cell line HEL
Immunofluorescent staining of human cell line HEL shows localization to Golgi apparatus.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/73356/1812_G3_5_cr5a09c41109818_blue_red_green.jpg
Normal Tissue
Figure 4 Bone marrow
Hematopoietic cells
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/361/2675_B_6_4.jpg
RNA Expression
Figure 5 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000105329-TGFB1
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More Infomation
Specifications
- Potential Clinical Applications
- Subcutanous F9 teratocarcinoma tumours
Product Composition
- Clone
- 31G9
- Antibody Type
- IgG
- Antibody Host
- Human
- Antibody Reactivity
- Human
- Antibody Description
- This is a recombinant human monoclonal antibody that was specifically engineered to target transforming growth factor-beta (TGF-β). TGF-β is a cytokine that plays a crucial role in various cellular processes, including immune regulation, cell growth, and tissue repair. By specifically binding to TGF-β, this monoclonal antibody can modulate its effects, potentially offering therapeutic benefits in diseases characterized by dysregulated TGF-β signaling, such as certain cancers, fibrosis, and autoimmune disorders.
Product Property
- Storage
- See in the COA
- Storage Shelf Time
- See in the COA
Target Information
- Target
- TGFB1
- Introduction
- This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with other TGFB family members. This encoded protein regulates cell proliferation, differentiation and growth, and can modulate expression and activation of other growth factors including interferon gamma and tumor necrosis factor alpha. This gene is frequently upregulated in tumor cells, and mutations in this gene result in Camurati-Engelmann disease.
- Alternative Names
- Transforming Growth Factor Beta 1; Prepro-Transforming Growth Factor Beta-1; TGF-Beta-1; TGFB; Transforming Growth Factor, Beta 1; Transforming Growth Factor Beta-1; Camurati-Engelmann Disease
- Full Name
- Transforming Growth Factor Beta 1
- Gene ID
- 7040
- UniProt ID
- P01137
- Sequence Similarities
- Belongs to the TGF-beta family.
- Cellular Localization
- Secreted
- Post Translation Modifications
- Transforming growth factor beta-1 proprotein: The precursor proprotein is cleaved in the Golgi apparatus by FURIN to form Transforming growth factor beta-1 (TGF-beta-1) and Latency-associated peptide (LAP) chains, which remain non-covalently linked, rendering TGF-beta-1 inactive.
- Protein Refseq
- XP_011525544.1; XP_054177872.1; NP_000651.3
- Function
- Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively.
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Related Diseases
Inflammatory Bowel Diseases
Downloadable Resources
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Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
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- Product Name
See other products for "Clone 31G9"
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- Product Name
See other products for "Tgfb1"
Select a product category from the dropdown menu below to view related products.
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| CAT | Product Name | Application | Type |
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| TAB-605CL | Human Anti-TGFB1 Recombinant Antibody (TAB-605CL) | ELISA | Human IgG |
| CAT | Product Name | Application | Type |
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| PABL-344 | Human Anti-TGFB1 Recombinant Antibody (PABL-344) | WB, ELISA, FuncS | Human IgG1, κ |
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| PSBL-344 | Human Anti-TGFB1 Recombinant Antibody (PSBL-344); scFv Fragment | WB, ELISA, FuncS | Human scFv |
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| PFBL-344 | Human Anti-TGFB1 Recombinant Antibody (PFBL-344); Fab Fragment | WB, ELISA, FuncS | Human Fab |
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| TAB-632CT | Mouse Anti-TGFB1 Recombinant Antibody (TAB-632CT) | ELISA, WB, FC, IP | Mouse IgG |
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| TAB-633CT | Mouse Anti-TGFB1 Recombinant Antibody (TAB-633CT) | ELISA, WB, FC, IP | Mouse IgG |
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| TAB-635CT | Human Anti-TGFB1 Recombinant Antibody (TAB-635CT) | ELISA, WB, FC, IP | Human IgG |
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| TAB-633CT-S(P) | Mouse Anti-TGFB1 Recombinant Antibody; scFv Fragment (TAB-633CT-S(P)) | ELISA, WB, FC, IP | Mouse scFv |
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| NEUT-2007CQ | Mouse Anti-TGFB1 Recombinant Antibody (NEUT-2007CQ) | IHC-Fr, WB, ELISA, IHC-Fr, Neut, FC | Mouse IgG1 |
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| NEUT-2009CQ | Mouse Anti-TGFB1 Recombinant Antibody (clone 9016.2) | ELISA, Inhib, WB | Mouse IgG1 |
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| MOR-3550 | Rabbit Anti-TGFB1 Recombinant Antibody (clone DS3550AB) | WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
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| MOR-4451 | Rabbit Anti-TGFB1 Recombinant Antibody (clone SI544DS) | ELISA | Rabbit IgG |
| CAT | Product Name | Application | Type |
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| HPAB-0018-YC | Human Anti-TGFB1 Recombinant Antibody (HPAB-0018-YC) | ELISA, Neut | Humanized IgG, κ |
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| HPAB-0018-YC-S(P) | Human Anti-TGFB1 Recombinant Antibody; scFv Fragment (HPAB-0018-YC-S(P)) | ELISA, Neut | Humanized scFv |
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| HPAB-0018-YC-F(E) | Human Anti-TGFB1 Recombinant Antibody; Fab Fragment (HPAB-0018-YC-F(E)) | ELISA, Neut | Humanized Fab |
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| HPAB-0492-CN-S(P) | Human Anti-TGFB1 Recombinant Antibody; scFv Fragment (HPAB-0492-CN-S(P)) | ELISA, FC, IF, Neut | Human scFv |
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| HPAB-0493-CN-S(P) | Human Anti-TGFB1 Recombinant Antibody; scFv Fragment (HPAB-0493-CN-S(P)) | ELISA, FC, IF, Neut | Human scFv |
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| HPAB-0494-CN-S(P) | Human Anti-TGFB1 Recombinant Antibody; scFv Fragment (HPAB-0494-CN-S(P)) | ELISA, Neut | Human scFv |
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| HPAB-0493-CN-F(E) | Human Anti-TGFB1 Recombinant Antibody; Fab Fragment (HPAB-0493-CN-F(E)) | ELISA, FC, IF, Neut | Human Fab |
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| HPAB-0494-CN-F(E) | Human Anti-TGFB1 Recombinant Antibody; Fab Fragment (HPAB-0494-CN-F(E)) | ELISA, Neut | Human Fab |
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| MHC-CN1265 | PE-A*02:01/Human TGFB1 (RLSSCVPVA) MHC Tetramer | FCM, IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-CN1266 | APC-A*02:01/Human TGFB1 (RLSSCVPVA) MHC Tetramer | FCM, IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-CN1267 | FITC-A*02:01/Human TGFB1 (RLSSCVPVA) MHC Tetramer | FCM, IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-CN1268 | A*02:01/Human TGFB1 (RLSSCVPVA) MHC Tetramer | FCM, IHC |
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| CAT | Product Name | Application | Type |
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| VS-0724-YC1506 | AbPlus™ Anti-TGFB1 Magnetic Beads (VS-0724-YC1506) | IP, Protein Purification |
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| VS-1024-XY503 | Mouse Anti-NHP TGFB1 Recombinant Antibody (clone 1D11.16.8) | WB, IF, ELISA | Mouse IgG1, kappa |
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