Anti-TGFB1 (clone Metelimumab) Recombinant Antibody Coupled Liposome (VS-1024-FY307)
CAT#: VS-1024-FY307
Anti-Tgfb1 antibody conjugated liposomes represent a promising advancement in targeted cancer therapy by offering a tailored approach to deliver therapeutic agents specifically to prostate cancer cells. This targeted delivery not only increases the efficacy of the treatment but also significantly reduces the potential for systemic toxicity, allowing for higher concentrations of the drug to be utilized directly where it is needed most. Furthermore, these specialized liposomes possess the unique capability to modulate the tumor microenvironment, which can foster a more robust immune response against the cancer cells. By overcoming the resistance mediated by TGF-β, this innovative strategy holds the potential to enhance overall treatment outcomes and improve the quality of life for patients battling prostate cancer.
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to cytosol & the Golgi apparatus.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/73356/1901_C17_1_selected.jpg
Subcellular Location and Protein Expression
Figure 2 IHC staining of human bone marrow
Immunohistochemical staining of human bone marrow shows strong cytoplasmic positivity in bone marrow poietic cells.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/361/ihc_selected.jpg
Subcellular Location and Protein Expression
Figure 3 IF staining of human cell line HEL
Immunofluorescent staining of human cell line HEL shows localization to Golgi apparatus.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/73356/1812_G3_5_cr5a09c41109818_blue_red_green.jpg
Normal Tissue
Figure 4 Bone marrow
Hematopoietic cells
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/361/2675_B_6_4.jpg
RNA Expression
Figure 5 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000105329-TGFB1
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More Infomation
Specifications
- Potential Clinical Applications
- Prostate cancer
Product Composition
- Clone
- Metelimumab
- Antibody Type
- IgG4
- Antibody Host
- Human
- Antibody Reactivity
- Human
- Antibody Description
- This is a recombinant human monoclonal that was meticulously designed to recognize and bind to Tgfb1, otherwise known as Transforming Growth Factor Beta 1. This targeted binding ensures efficient interaction with the Tgfb1 protein, which plays a crucial role in regulating cellular growth and differentiation. As a result, this monoclonal antibody serves as a valuable tool for investigating Tgfb1's involvement in various physiological and pathological conditions.
Product Property
- Storage
- See in the COA
- Storage Shelf Time
- See in the COA
Target Information
- Target
- TGFB1
- Introduction
- This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with other TGFB family members. This encoded protein regulates cell proliferation, differentiation and growth, and can modulate expression and activation of other growth factors including interferon gamma and tumor necrosis factor alpha. This gene is frequently upregulated in tumor cells, and mutations in this gene result in Camurati-Engelmann disease.
- Alternative Names
- Transforming Growth Factor Beta 1; Prepro-Transforming Growth Factor Beta-1; TGF-Beta-1; TGFB; Transforming Growth Factor, Beta 1; Transforming Growth Factor Beta-1; Camurati-Engelmann Disease
- Full Name
- Transforming Growth Factor Beta 1
- Gene ID
- 7040
- UniProt ID
- P01137
- Sequence Similarities
- Belongs to the TGF-beta family.
- Cellular Localization
- Secreted
- Post Translation Modifications
- Transforming growth factor beta-1 proprotein: The precursor proprotein is cleaved in the Golgi apparatus by FURIN to form Transforming growth factor beta-1 (TGF-beta-1) and Latency-associated peptide (LAP) chains, which remain non-covalently linked, rendering TGF-beta-1 inactive.
- Protein Refseq
- XP_011525544.1; XP_054177872.1; NP_000651.3
- Function
- Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively.
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Related Diseases
Inflammatory Bowel Diseases
Downloadable Resources
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Datasheet
MSDS
COA
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-762 | Anti-TGFB1 Recombinant Antibody (TAB-762) | FC, IP, ELISA, Neut, FuncS, IF, ICC | IgG4 - kappa |
| TAB-140 | Anti-Human TGF-β Recombinant Antibody (TAB-140) | Neut, ELISA, IF, IP, FuncS, FC, ICC | IgG4 - kappa |
| TAB-635CT-S(P) | Human Anti-TGFB1 Recombinant Antibody; scFv Fragment (TAB-635CT-S(P)) | ELISA, WB, FC, IP | Human scFv |
| TAB-636CT-S(P) | Human Anti-TGFB1 Recombinant Antibody; scFv Fragment (TAB-636CT-S(P)) | ELISA, WB, FC, IP | Human scFv |
| TAB-637CT-S(P) | Human Anti-TGFB1 Recombinant Antibody; scFv Fragment (TAB-637CT-S(P)) | ELISA, WB, FC, IP | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-605CL | Human Anti-TGFB1 Recombinant Antibody (TAB-605CL) | ELISA | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBL-344 | Human Anti-TGFB1 Recombinant Antibody (PSBL-344); scFv Fragment | WB, ELISA, FuncS | Human scFv |
| HPAB-0018-YC-S(P) | Human Anti-TGFB1 Recombinant Antibody; scFv Fragment (HPAB-0018-YC-S(P)) | ELISA, Neut | Humanized scFv |
| HPAB-N0392-YC-S(P) | Human Anti-TGFB1 Recombinant Antibody; scFv Fragment (HPAB-N0392-YC-S(P)) | ELISA, Inhib | Human scFv |
| HPAB-N0393-YC-S(P) | Human Anti-TGFB1 Recombinant Antibody; scFv Fragment (HPAB-N0393-YC-S(P)) | ELISA, Inhib | Human scFv |
| HPAB-N0394-YC-S(P) | Human Anti-TGFB1 Recombinant Antibody; scFv Fragment (HPAB-N0394-YC-S(P)) | IHC, Neut, FuncS | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBL-344 | Human Anti-TGFB1 Recombinant Antibody (PFBL-344); Fab Fragment | WB, ELISA, FuncS | Human Fab |
| HPAB-N0392-YC-F(E) | Human Anti-TGFB1 Recombinant Antibody; Fab Fragment (HPAB-N0392-YC-F(E)) | ELISA, Inhib | Human Fab |
| HPAB-N0393-YC-F(E) | Human Anti-TGFB1 Recombinant Antibody; Fab Fragment (HPAB-N0393-YC-F(E)) | ELISA, Inhib | Human Fab |
| HPAB-N0394-YC-F(E) | Human Anti-TGFB1 Recombinant Antibody; Fab Fragment (HPAB-N0394-YC-F(E)) | IHC, Neut, FuncS | Human Fab |
| HPAB-0737LY-F(E) | Mouse Anti-TGFB1 Recombinant Antibody; Fab Fragment (HPAB-0737LY-F(E)) | ELISA | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-632CT-S(P) | Mouse Anti-TGFB1 Recombinant Antibody; scFv Fragment (TAB-632CT-S(P)) | ELISA, WB, FC, IP | Mouse scFv |
| TAB-633CT-S(P) | Mouse Anti-TGFB1 Recombinant Antibody; scFv Fragment (TAB-633CT-S(P)) | ELISA, WB, FC, IP | Mouse scFv |
| TAB-632CT-F(E) | Mouse Anti-TGFB1 Recombinant Antibody; Fab Fragment (TAB-632CT-F(E)) | ELISA, WB, FC, IP | Mouse Fab |
| TAB-633CT-F(E) | Mouse Anti-TGFB1 Recombinant Antibody; Fab Fragment (TAB-633CT-F(E)) | ELISA, WB, FC, IP | Mouse Fab |
| TAB-634CT-F(E) | Mouse Anti-TGFB1 Recombinant Antibody; Fab Fragment (TAB-634CT-F(E)) | ELISA, WB, FC, IP | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-1110MZ | Chicken Anti-Human TGF (beta) Polyclonal IgY Conjugated to PE-Cy5.5 | ELISA, WB, IHC, ICC, IF, IP, FC | Chicken antibody |
| BRD-1111MZ | Chicken Anti-Human TGF (beta) Polyclonal IgY Conjugated to PE-Cy7 | ELISA, WB, IHC, ICC, IF, IP, FC | Chicken antibody |
| BRD-1112MZ | Chicken Anti-Human TGF (beta) Polyclonal IgY Conjugated to PerCP | ELISA, WB, IHC, ICC, IF, IP, FC | Chicken antibody |
| BRD-1113MZ | Chicken Anti-Human TGF (beta) Polyclonal IgY Conjugated to PerCP-Cy5.5 | ELISA, WB, IHC, ICC, IF, IP, FC | Chicken antibody |
| BRD-1114MZ | Chicken Anti-Human TGF (beta) Polyclonal IgY Conjugated to Rhodamine | ELISA, WB, IHC, ICC, IF, IP, FC | Chicken antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-2003CQ | Mouse Anti-TGFB1 Recombinant Antibody (clone CBL443) | Neut | Mouse IgG1 |
| NEUT-2004CQ | Mouse Anti-Tgfb1 Recombinant Antibody (NEUT-2004CQ) | FC, WB, IP, Neut | Mouse IgG2b, κ |
| NEUT-2005CQ | Mouse Anti-Tgfb1 Recombinant Antibody (NEUT-2005CQ) | FC, IP, Neut, WB | Mouse IgG1, κ |
| NEUT-2006CQ | Mouse Anti-TGFB1 Recombinant Antibody (clone 1D11.16.8) | Neut | Mouse IgG1 |
| NEUT-2007CQ | Mouse Anti-TGFB1 Recombinant Antibody (NEUT-2007CQ) | IHC-Fr, WB, ELISA, IHC-Fr, Neut, FC | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-2009CQ | Mouse Anti-TGFB1 Recombinant Antibody (clone 9016.2) | ELISA, Inhib, WB | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3550 | Rabbit Anti-TGFB1 Recombinant Antibody (clone DS3550AB) | WB | Rabbit IgG |
| MOR-4451 | Rabbit Anti-TGFB1 Recombinant Antibody (clone SI544DS) | ELISA | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0308CQ | Mouse Anti-TGFB1 Recombinant Antibody (clone mAb 2471) | ELISA, Neut, FC | Mouse IgG |
| HPAB-0309CQ | Mouse Anti-TGFB1 Recombinant Antibody (clone mAb 1021) | ELISA, Neut, FC | Mouse IgG |
| HPAB-0310CQ | Mouse Anti-TGFB1 Recombinant Antibody (clone mAb 3821) | ELISA, Neut, FC | Mouse IgG |
| HPAB-0311CQ | Human Anti-TGFB1 Recombinant Antibody (HPAB-0311CQ) | ELISA, Neut, FuncS | Human IgG4, κ |
| HPAB-0312CQ | Human Anti-TGFB1 Recombinant Antibody (HPAB-0312CQ) | ELISA, Neut, FuncS | Human IgG4, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-140 | Afuco™ Anti-TGFB1 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-140) | Neut, ELISA, IF, IP, FuncS, FC | ADCC enhanced antibody |
| AFC-TAB-762 | Afuco™ Anti-TGFB1 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-762) | FC, IP, ELISA, Neut, FuncS, IF | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-CN1265 | PE-A*02:01/Human TGFB1 (RLSSCVPVA) MHC Tetramer | FCM, IHC | |
| MHC-CN1266 | APC-A*02:01/Human TGFB1 (RLSSCVPVA) MHC Tetramer | FCM, IHC | |
| MHC-CN1267 | FITC-A*02:01/Human TGFB1 (RLSSCVPVA) MHC Tetramer | FCM, IHC | |
| MHC-CN1268 | A*02:01/Human TGFB1 (RLSSCVPVA) MHC Tetramer | FCM, IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0424-XY252 | AbPlus™ Anti-TGFB1 Magnetic Beads (VS-0424-XY252) | IP, Protein Purification | |
| VS-0724-YC1506 | AbPlus™ Anti-TGFB1 Magnetic Beads (VS-0724-YC1506) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1024-XY503 | Mouse Anti-NHP TGFB1 Recombinant Antibody (clone 1D11.16.8) | WB, IF, ELISA | Mouse IgG1, kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0125-FY14 | Human Anti-TGFB1 (clone 31G9) scFv-Fc Chimera | ELISA, Block | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY7208 | Anti-TGFB1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY7209 | Anti-Mouse TGFB1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY7210 | Anti-Rat TGFB1 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-YC230 | Recombinant Anti-TGFB1 Biparatopic Antibody, Tandem scFv | ELISA, FC, ICC, IF, IP, Neut | Tandem scFv |
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