Human Anti-TGFB1 Recombinant Antibody (VS-0724-XY94)
CAT#: VS-0724-XY94
Provided are recombinant human antibodies binding to TGFB1 (Transforming growth factor beta 1), which regulates cell proliferation, differentiation and growth. The antibody has affinity against human TGFB1. They have been reported for use in ELISA, Bio-layer interferometry and Neutralizaiton assay.
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to cytosol & the Golgi apparatus.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/73356/1901_C17_1_selected.jpg
Subcellular Location and Protein Expression
Figure 2 IHC staining of human bone marrow
Immunohistochemical staining of human bone marrow shows strong cytoplasmic positivity in bone marrow poietic cells.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/361/ihc_selected.jpg
Subcellular Location and Protein Expression
Figure 3 IF staining of human cell line HEL
Immunofluorescent staining of human cell line HEL shows localization to Golgi apparatus.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/73356/1812_G3_5_cr5a09c41109818_blue_red_green.jpg
Normal Tissue
Figure 4 Bone marrow
Hematopoietic cells
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/361/2675_B_6_4.jpg
RNA Expression
Figure 5 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000105329-TGFB1
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| Sub Cat | Clone | Affinity Constant | Size | Conjugation | Endotoxin | Purity | Fc Engineering | |
| VS-0724-XY90 | 3.A | KD = 0.002 nM | ||||||
| VS-0724-XY91 | 23A3 | KD = 0.0008 nM |
More Infomation
Specifications
- Host Species
- Human
- Type
- Human IgG
- Specificity
- TGFB1
- Species Reactivity
- Human
- Applications
- ELISA, BLI, Neut
- Related Disease
- Camurati-Engelmann Disease
Product Property
- Purification
- Protein A affinity purified
- Purity
- >95%, determined by SDS-PAGE
- Format
- Liquid
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Applications
- Application Notes
- BLI: The KD value of clone 3.A agaisnt TGFB1 is 0.002 nM.
The KD value of clone 23A3 agaisnt TGFB1 is 0.0008 nM.
Target
- Alternative Names
- CED; LAP; DPD1; TGFB; IBDIMDE; TGFbeta; TGF-beta1
- Gene ID
- 7040
- UniProt ID
- P01137
- Cellular Localization
- Secreted
- Post Translation Modifications
- Glycosylation at Asn82, Asn136, and Asn176.
Ubiquitination at Lys291.
- Protein Refseq
- XP_011525544.1; XP_054177872.1; NP_000651.3
- Function
- Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively.
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Related Diseases
Inflammatory Bowel Diseases
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Isotype Control
- CAT
- Product Name
Recommended Dilution Buffer
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| NEUT-2007CQ | Mouse Anti-TGFB1 Recombinant Antibody (NEUT-2007CQ) | IHC-Fr, WB, ELISA, IHC-Fr, Neut, FC | Mouse IgG1 |
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0018-YC | Human Anti-TGFB1 Recombinant Antibody (HPAB-0018-YC) | ELISA, Neut | Humanized IgG, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0018-YC-S(P) | Human Anti-TGFB1 Recombinant Antibody; scFv Fragment (HPAB-0018-YC-S(P)) | ELISA, Neut | Humanized scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0018-YC-F(E) | Human Anti-TGFB1 Recombinant Antibody; Fab Fragment (HPAB-0018-YC-F(E)) | ELISA, Neut | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0492-CN-S(P) | Human Anti-TGFB1 Recombinant Antibody; scFv Fragment (HPAB-0492-CN-S(P)) | ELISA, FC, IF, Neut | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0493-CN-S(P) | Human Anti-TGFB1 Recombinant Antibody; scFv Fragment (HPAB-0493-CN-S(P)) | ELISA, FC, IF, Neut | Human scFv |
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|---|---|---|---|
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0492-CN-F(E) | Human Anti-TGFB1 Recombinant Antibody; Fab Fragment (HPAB-0492-CN-F(E)) | ELISA, FC, IF, Neut | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0493-CN-F(E) | Human Anti-TGFB1 Recombinant Antibody; Fab Fragment (HPAB-0493-CN-F(E)) | ELISA, FC, IF, Neut | Human Fab |
| CAT | Product Name | Application | Type |
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|---|---|---|---|
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-CN1267 | FITC-A*02:01/Human TGFB1 (RLSSCVPVA) MHC Tetramer | FCM, IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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