APC-B*27:05/Human BRAF (GRFGLATVK) MHC Tetramer (CAT#: MHC-CN0462)

• Allele
• B*27:05

• Class
• Class I

• MHC Species
• Human

• Antigen
• BRAF

• Antigen Species
• Human

• Peptide
• GRFGLATVK

• Conjugate
• APC

• Application
• FCM, IHC

• Antigen Introduction
• This gene encodes a protein belonging to the RAF family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which affects cell division, differentiation, and secretion. Mutations in this gene, most commonly the V600E mutation, are the most frequently identified cancer-causing mutations in melanoma, and have been identified in various other cancers as well, including non-Hodgkin lymphoma, colorectal cancer, thyroid carcinoma, non-small cell lung carcinoma, hairy cell leukemia and adenocarcinoma of lung. Mutations in this gene are also associated with cardiofaciocutaneous, Noonan, and Costello syndromes, which exhibit overlapping phenotypes. A pseudogene of this gene has been identified on the X chromosome. [provided by RefSeq, Aug 2017]

• Alternative Names
• NS7; B-raf; BRAF1; RAFB1; B-RAF1

• Gene ID
• 673

• UniProt ID
• P15056

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