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BRAF
Tetramer Products
Antibody Magnetic Beads
AbPlus
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Formats
Anti-BRAF Recombinant Antibody Products
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- Derivation: Mouse
- Species Reactivity: Human, Mouse, Rat
- Type: Mouse IgG
- Application: WB, ICC
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- Derivation: Mouse
- Species Reactivity: Human, Mouse
- Type: Mouse IgG1
- Application: WB, IHC, ICC, FC, ELISA
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- Class: Class I
- Antigen: BRAF (600E)
- Antigen Species: Human
- Peptide: GRFGLATEK
- Conjugate: Unlabeled, Biotin, R-PE, APC
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- Class: Class I
- Antigen: BRAF (600V)
- Antigen Species: Human
- Peptide: GRFGLATVK
- Conjugate: Unlabeled, Biotin, R-PE, APC
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- Human Anti-BRAF Antibody, mRNA (TAB-072CL-mRNA)
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- Species Reactivity: Human
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- FITC-B*27:05/Human BRAF (GRFGLATEK) MHC Tetramer (MHC-CN0459)
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- Class: Class I
- Antigen: BRAF
- Antigen Species: Human
- Peptide: GRFGLATEK
- Conjugate: FITC
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- B*27:05/Human BRAF (GRFGLATEK) MHC Tetramer (MHC-CN0460)
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- Class: Class I
- Antigen: BRAF
- Antigen Species: Human
- Peptide: GRFGLATEK
- Conjugate: Unconjugated
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- PE-B*27:05/Human BRAF (GRFGLATVK) MHC Tetramer (MHC-CN0461)
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- Class: Class I
- Antigen: BRAF
- Antigen Species: Human
- Peptide: GRFGLATVK
- Conjugate: PE
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- APC-B*27:05/Human BRAF (GRFGLATVK) MHC Tetramer (MHC-CN0462)
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- Class: Class I
- Antigen: BRAF
- Antigen Species: Human
- Peptide: GRFGLATVK
- Conjugate: APC
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- FITC-B*27:05/Human BRAF (GRFGLATVK) MHC Tetramer (MHC-CN0463)
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- Class: Class I
- Antigen: BRAF
- Antigen Species: Human
- Peptide: GRFGLATVK
- Conjugate: FITC
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- B*27:05/Human BRAF (GRFGLATVK) MHC Tetramer (MHC-CN0464)
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- Class: Class I
- Antigen: BRAF
- Antigen Species: Human
- Peptide: GRFGLATVK
- Conjugate: Unconjugated
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- Recombinant Anti-human BRAF Antibody (MOB-122)
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- Derivation: Mouse
- Species Reactivity: Human
- Type: IgG
- Application: ELISA, WB, Dot, FuncS
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- AbPlus™ Anti-BRAF Magnetic Beads (CBACN-057) (VS-0424-XY32)
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- Target: BRAF
- Target Species: Human, Mouse, Rat
- Application: IP, Protein Purification
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- Rabbit Anti-BRAF Recombinant Antibody (clone CBACN-057) (MRO-0148-CN)
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- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IHC, IP, FC
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- Mouse Anti-BRAF Recombinant Antibody (clone F1-F4-E10) (MRO-0189-CN)
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- Species Reactivity: Human, Mouse, Rat
- Type: Mouse IgG2b
- Application: WB, IHC, IF
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- Rabbit Anti-BRAF Recombinant Antibody (clone CBACN-596) (MRO-2303-CN)
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- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IF, IP
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- PE-B*27:05/Human BRAF (GRFGLATEK) MHC Tetramer (MHC-CN0457)
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- Class: Class I
- Antigen: BRAF
- Antigen Species: Human
- Peptide: GRFGLATEK
- Conjugate: PE
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- APC-B*27:05/Human BRAF (GRFGLATEK) MHC Tetramer (MHC-CN0458)
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- Class: Class I
- Antigen: BRAF
- Antigen Species: Human
- Peptide: GRFGLATEK
- Conjugate: APC
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- Anti-Human BRAF Recombinant Antibody (TAB-072CL)
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Antibody
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- Mouse Anti-BRAF Recombinant Antibody (clone 2I23) (MOB-0876MZ)
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ELISA, IHC-P, WB
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- Anti-Human BRAF Recombinant Antibody scFv Fragment (CCTCC C2012122) (TAB-1284CL-S(P))
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- Application: IB, IF
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- Anti-Human BRAF Recombinant Antibody Fab Fragment (CCTCC C2012122) (TAB-1284CL-F(E))
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- Application: IB, IF
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- Rabbit Anti-NHP BRAF Recombinant Antibody (VS-1024-XY56) (VS-1024-XY56)
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- Species Reactivity: Human, Mouse, Non-human primate, Rat
- Type: Rabbit IgG
- Application: WB
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- Recombinant Human Anti-human BRAF Antibody Fab Fragment (MHH-122-F(E))
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- Derivation: Human
- Species Reactivity: Human
- Type: Fab
- Application: ELISA, WB, Neut, FuncS
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- Recombinant Human Anti-human BRAF Antibody scFv Fragment (MHH-122-S(P))
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- Derivation: Human
- Species Reactivity: Human
- Type: scFv
- Application: WB, Neut, FuncS
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- Recombinant Anti-human BRAF Antibody Fab Fragment (MOB-122-F(E))
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Fab
- Application: IF, Neut, FuncS
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- Recombinant Anti-human BRAF Antibody scFv Fragment (MOB-122-S(P))
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- Derivation: Mouse
- Species Reactivity: Human
- Type: scFv
- Application: ELISA, IF, FuncS
Compare
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- Derivation: Mouse
- Species Reactivity: Human, Mouse
- Type: Mouse IgG1
- Application: WB, IHC, ICC
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- Derivation: Mouse
- Species Reactivity: Human, Mouse
- Type: Mouse IgG
- Application: WB, IHC-p, IF, ICC, ELISA
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For Research Use Only. Not For Clinical Use.
This gene encodes a protein belonging to the raf/mil family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERKs signaling pathway, which affects cell division, differentiation, and secretion. Mutations in this gene are associated with cardiofaciocutaneous syndrome, a disease characterized by heart defects, mental retardation and a distinctive facial appearance. Mutations in this gene have also been associated with various cancers, including non-Hodgkin lymphoma, colorectal cancer, malignant melanoma, thyroid carcinoma, non-small cell lung carcinoma, and adenocarcinoma of lung. A pseudogene, which is located on chromosome X, has been identified for this gene.
Protein class
Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Excitatory neurons, Inhibitory neurons, Oligodendrocyte precursor cells, Oligodendrocytes)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Monomer. Homodimer. Heterodimerizes with RAF1, and the heterodimer possesses a highly increased kinase activity compared to the respective homodimers or monomers. Heterodimerization is mitogen-regulated and enhanced by 14-3-3 proteins. MAPK1/ERK2 activation can induce a negative feedback that promotes the dissociation of the heterodimer by phosphorylating BRAF at Thr-753. Heterodimerizes (via N-terminus) with KSR1 (via N-terminus) or KSR2 (via N-terminus) in a MAP2K1-dependent manner (PubMed:29433126). Interacts with MAP2K1 and MAP2K2 (PubMed:29433126). Found in a complex with at least BRAF, HRAS, MAP2K1, MAPK3 and RGS14. Interacts with RIT1. Interacts (via N-terminus) with RGS14 (via RBD domains); the interaction mediates the formation of a ternary complex with RAF1, a ternary complex inhibited by GNAI1 (By similarity). Interacts with DGKH (PubMed:19710016). Interacts with PRMT5 (PubMed:21917714). Interacts with KSR2 (PubMed:21441910). Interacts with AKAP13, MAP2K1 and KSR1. Identified in a complex with AKAP13, MAP2K1 and KSR1 (PubMed:21102438). Interacts with FNIP1 and FNIP2 (PubMed:27353360).
Molecular function
Allosteric enzyme, Kinase, Serine/threonine-protein kinase, Transferase
More Types Infomation
Related Signaling Pathways
cAMP Signaling Pathway
MAPK Signaling Pathway
Related Diseases
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