Human Anti-GCGR scFv-Fc Chimera (VS-0425-FY112) (CAT#: VS-0425-FY112)

• Immunogen
• The immunogen was the human glucagon receptor expressed on cells.

• Host Species
• Human

• Type
• Human IgG1, scFv-Fc

• Specificity
• Human GCGR

• Species Reactivity
• Human

• Applications
• Inhibition

• Related Disease
• Metabolic Disorders (Not Specified); Hyperglycemic Agents; Type 2 Diabetes

• Purity
• >95% as determined by SDS-PAGE

• Concentration
• Please refer to the vial label for the specific concentration.

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

• Shipping
• Ice packs

• Application Notes
• The optimal dilution concentration is determined by the experiment.

• Alternative Names
• Glucagon Receptor; GL-R; GGR

• Gene ID
• 2642

• UniProt ID
• P47871

• Long Name
• Glucagon Receptor

• Sequence Similarities
• Belongs to the G-protein coupled receptor 2 family.

• Cellular Localization
• Cell membrane

• Post Translation Modifications
• Ligand-binding promotes phosphorylation of serine residues in the C-terminal cytoplasmic domain.
  Phosphorylation is important for receptor endocytosis after ligand-binding.
  Glycosylation at Asn46, Asn59, Asn74, and Asn78
  Modification sites at PhosphoSitePlus
  Glycosylation from GlyGen 4 sites

• Protein Refseq
• XP_006722340.1; XP_011521841.1; XP_016879935.1; XP_054171686.1; XP_054171687.1

• Function
• G-protein coupled receptor for glucagon that plays a central role in the regulation of blood glucose levels and glucose homeostasis.
  Regulates the rate of hepatic glucose production by promoting glycogen hydrolysis and gluconeogenesis.
  Plays an important role in mediating the responses to fasting.
  Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase.
  Promotes activation of adenylate cyclase.

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