Human Anti-GCGR scFv-Fc Chimera (VS-0425-FY112)
CAT#: VS-0425-FY112
This fusion protein targets GCGR (Glucagon receptor), a receptor involved in glucose and lipid metabolism. By inhibiting GCGR, it can modulate glucagon signaling and has potential applications in treating diabetes and other metabolic disorders.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to the Golgi apparatus.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/71228/1338_A11_7_selected.jpg
RNA Expression
Figure 2 RNA cell line category: Cell line enhanced (HeLa, MCF7, SK-BR-3, U-87 MG)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000215644-GCGR
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Specifications
- Immunogen
- The immunogen was the human glucagon receptor expressed on cells.
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Antibody Isotype
- scFv-Fc
- Specificity
- Human GCGR
- Species Reactivity
- Human
- Applications
- Inhibition
- Related Disease
- Metabolic Disorders (Not Specified); Hyperglycemic Agents; Type 2 Diabetes
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- The optimal dilution concentration is determined by the experiment.
Target
- Alternative Names
- Glucagon Receptor; GL-R; GGR
- Gene ID
- 2642
- UniProt ID
- P47871
- Long Name
- Glucagon Receptor
- Sequence Similarities
- Belongs to the G-protein coupled receptor 2 family.
- Cellular Localization
- Cell membrane
- Post Translation Modifications
- Ligand-binding promotes phosphorylation of serine residues in the C-terminal cytoplasmic domain.
Phosphorylation is important for receptor endocytosis after ligand-binding.
Glycosylation at Asn46, Asn59, Asn74, and Asn78
Modification sites at PhosphoSitePlus
Glycosylation from GlyGen 4 sites
- Protein Refseq
- XP_006722340.1; XP_011521841.1; XP_016879935.1; XP_054171686.1; XP_054171687.1
- Function
- G-protein coupled receptor for glucagon that plays a central role in the regulation of blood glucose levels and glucose homeostasis.
Regulates the rate of hepatic glucose production by promoting glycogen hydrolysis and gluconeogenesis.
Plays an important role in mediating the responses to fasting.
Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase.
Promotes activation of adenylate cyclase.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
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