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Anti-Human GCGR Recombinant Antibody (mAb5) (CAT#: TAB-063CQ)

The antibody recognizes a functional epitope on human glucagon receptor and can be used to lower glucose levels in blood. It can be potentially used in the prevention and treatment of glucose-related disorders, including diabetes, hyperglycemia, hyperinsulinemia and so on.


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  • Published Data
  • Gene Expression
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Figure 1 depicts a graph summarizing results of a cAMP assay.

Figure 1 depicts a graph summarizing results of a cAMP assay.

Figure 2 depicts a graph summarizing the results of an alanine aminotransferase (ALT) test in animals administered either anti-glucagon receptor antagonist antibody mAb5 (open circles) or PBS (closed circles).

Figure 2 depicts a graph summarizing the results of an alanine aminotransferase (ALT) test in animals administered either anti-glucagon receptor antagonist antibody mAb5 (open circles) or PBS (closed circles).

Figure 3 depicts a graph summarizing the results of an aspartate aminotransferase (AST) test in animals administered either mAb5 (open circles) or PBS (closed circles).

Figure 3 depicts a graph summarizing the results of an aspartate aminotransferase (AST) test in animals administered either mAb5 (open circles) or PBS (closed circles).

Figure 4 depicts a graph summarizing the results of agamma-glutamyltransferase (GGT) test in animals administered either mAb5 (open circles) or PBS (closed circles).

Figure 4 depicts a graph summarizing the results of agamma-glutamyltransferase (GGT) test in animals administered either mAb5 (open circles) or PBS (closed circles).


Specifications

  • Immunogen
  • Human glucagon receptor
  • Host Species
  • Mouse
  • Specificity
  • Human
  • Species Reactivity
  • Human, Cynomolgus monkey
  • Clone
  • mAb5
  • Applications
  • ELISA, FC, FuncS
  • Related Disease
  • Type 2 Diabetes

Applications

  • Application Notes
  • Cell Based Functional Assay
    cAMP signaling was measured in a CHO cell line stably transfected with human glucagon receptor, using a LANCE® cAMP kit. Cells were added to a 96-well plate and incubated with serially diluted mAb5. Cells were then stimulated with 200 pM glucagon for 30 minutes at room temperature (RT). Detection antibody was then added and incubated for 10 minutes at RT. Cells were then lysed with supplied detection buffer and incubated in the dark for 3 hours at RT. The plate was then read on a VICTOR3™ plate reader. As the readout of this assay is based on competition between a labeled, exogenous cAMP (measured at 665 nm) and unlabeled, endogenously generated cAMP, higher signals indicate less cAMP generated by the cells. mAb5 inhibits cAMP generation in a dose-dependent fashion.

Target

  • Alternative Names
  • GCGR; glucagon receptor; GGR; GL-RR

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "Clone mAb5"

See other products for "GCGR"

Recombinant Antibody

CAT Product Name Application Type
MOB-1786z Mouse Anti-GCGR Recombinant Antibody (clone 40C5) WB, ELISA Mouse IgG1, κ
HPAB-0817-FY Human Anti-GCGR Recombinant Antibody (HPAB-0817-FY) ELISA, RIA, FC Human IgG
HPAB-0818-FY Human Anti-GCGR Recombinant Antibody (HPAB-0818-FY) ELISA, RIA, FC Human IgG
HPAB-0819-FY Human Anti-GCGR Recombinant Antibody (HPAB-0819-FY) ELISA, RIA, FC Human IgG
HPAB-0820-FY Human Anti-GCGR Recombinant Antibody (HPAB-0820-FY) ELISA, RIA, FC Human IgG

Humanized Antibody

CAT Product Name Application Type
TAB-066CQ Anti-Human GCGR Recombinant Antibody (3C7v11) ELISA, FC, WB Humanized antibody
TAB-066CQ-S(P) Anti-Human GCGR Recombinant Antibody scFv Fragment (3C7v11) ELISA, FC, WB Humanized antibody
TAB-066CQ-F(E) Anti-Human GCGR Recombinant Antibody Fab Fragment (3C7v11) ELISA, FC, WB Humanized antibody

Human Antibody

CAT Product Name Application Type
TAB-068CQ Human Anti-GCGR Recombinant Antibody (TAB-068CQ) ELISA, FC Human IgG2
TAB-069CQ Human Anti-GCGR Recombinant Antibody (TAB-069CQ) FuncS, Block Human IgG2
TAB-065CQ-S(P) Anti-Human GCGR Recombinant Antibody scFv Fragment (H6.23v3) ELISA, FC, WB Human antibody
TAB-065CQ-F(E) Anti-Human GCGR Recombinant Antibody Fab Fragment (H6.23v3) ELISA, FC, WB Human antibody
PABX-067-S (P) Recombinant Mouse Anti-GR-2 Antibody scFv Fragment (F6) WB, Neut, FuncS scFv

Mouse Antibody

CAT Product Name Application Type
TAB-063CQ-S(P) Anti-Human GCGR Recombinant Antibody scFv Fragment (mAb5) ELISA, FC
TAB-064CQ-S(P) Anti-Human GCGR Recombinant Antibody scFv Fragment (3C7) ELISA, FC, WB
TAB-067CQ-S(P) Mouse Anti-GCGR Recombinant Antibody; scFv Fragment (TAB-067CQ-S(P)) ELISA, FC Mouse scFv
PABX-067 Recombinant Mouse Anti-GR-2 Antibody (F6) WB, Neut, FuncS IgG
PABX-067-F (E) Recombinant Mouse Anti-GR-2 Antibody Fab Fragment (F6) WB, Neut, FuncS Fab

Fc Glycosylation

CAT Product Name Application Type
Gly-113LC Recombinant Anti-Human GCGR Antibody (Fc glycosylation) ELISA Chimeric antibody (mouse/human)

MHC Tetramer for Cancer

CAT Product Name Application Type
MHC-LC1322 PE-B*27:05/Human GCGR (RRRWHRWRL) MHC Tetramer FCM
MHC-LC1448 PE-B*27:09/Human GCGR (RRRWHRWRL) MHC Tetramer FCM
MHC-LC1323 APC-B*27:05/Human GCGR (RRRWHRWRL) MHC Tetramer FCM
MHC-LC1324 BV421-B*27:05/Human GCGR (RRRWHRWRL) MHC Tetramer FCM
MHC-LC1450 BV421-B*27:09/Human GCGR (RRRWHRWRL) MHC Tetramer FCM

Fab Fragment Antibody

CAT Product Name Application Type
HPAB-0023-LS-S(P) Mouse Anti-GCGR Recombinant Antibody (clone 6.23V3); scFv Fragment WB, FC Mouse scFv
HPAB-0138-FY-F(E) Human Anti-GCGR Recombinant Antibody; Fab Fragment (HPAB-0138-FY-F(E)) Block Human Fab
HPAB-0817-FY-S(P) Human Anti-GCGR Recombinant Antibody; scFv Fragment (HPAB-0817-FY-S(P)) ELISA, RIA, FC Human scFv
HPAB-0818-FY-S(P) Human Anti-GCGR Recombinant Antibody; scFv Fragment (HPAB-0818-FY-S(P)) ELISA, RIA, FC Human scFv
HPAB-0819-FY-S(P) Human Anti-GCGR Recombinant Antibody; scFv Fragment (HPAB-0819-FY-S(P)) ELISA, RIA, FC Human scFv

scFv Fragment Antibody

CAT Product Name Application Type
HPAB-0105LY-S(P) Human Anti-GCGR Recombinant Antibody; scFv Fragment (HPAB-0105LY-S(P)) ELISA Human scFv
HPAB-3045LY-S(P) Human Anti-GCGR Recombinant Antibody; scFv Fragment (HPAB-3045LY-S(P)) ELISA Human scFv
HPAB-3385LY-S(P) Human Anti-GCGR Recombinant Antibody (clone CBL150); scFv Fragment ELISA Human scFv
HPAB-3386LY-S(P) Human Anti-GCGR Recombinant Antibody (clone CBL151); scFv Fragment ELISA Human scFv
HPAB-3387LY-S(P) Human Anti-GCGR Recombinant Antibody (clone CBL152); scFv Fragment ELISA Human scFv

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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