Recombinant Rabbit Anti-IL1B Capture Antibody (clone R02-6S1)
CAT#: VS3-WK1686
This antibody is a rabbit recombinant antibody against human IL1B. It was developed by immunization of rabbit with recombinant human IL1B protein and then was produced as a recombinant antibody. The isotype of this product is rabbit IgG. The sandwich ELISA was established using matched antibody pair R02-6S1 and R05-7O9. The clone R02-6S1 can be used as a capture antibody in ELISA analysis to identify human IL1B.
Gene Expression
RNA Expression
Figure 1 RNA cell line category: Cell line enhanced.
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000125538-IL1B
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Specifications
- Immunogen
- Recombinant human IL1B protein
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human IL1B
- Species Reactivity
- Human
- Clone
- R02-6S1
- Applications
- ELISA
- Conjugate
- Unconjugated
Product Property
- Clonality
- Monoclonal
- Purification
- Protein A affinity purified
- Purity
- >95% as determined by SDS-PAGE
- Aggregation
- < 5%
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- 0.01M PBS, pH 7.2
- Storage
- Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
- Shipping
- Ice packs
Target
- Alternative Names
- Interleukin 1 Beta
- Gene ID
- 3553
- UniProt ID
- P01584
- Long Name
- Interleukin 1 Beta
- Sequence Similarities
- Belongs to the IL-1 family.
- Cellular Localization
- Cytoplasm, Lysosome, Secreted
- Post Translation Modifications
- Activation of the IL1B precursor involves a CASP1-catalyzed proteolytic cleavage. Processing and secretion are temporarily associated.
(Microbial infection) Cleavage by S.pyogenes cysteine protease SpeB promotes its activation independently of CASP1.
- Protein Refseq
- NP_000567.1
- Function
- Potent pro-inflammatory cytokin.
Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production.
Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells
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Related Diseases
Rheumatoid Arthritis
Maturity Onset Diabetes of the Young
Related Signaling Pathways
TNF Signaling Pathway
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Detection antibody
Isotype Control
- CAT
- Product Name
Secondary Antibody
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