ITGAV & Ad fiber knob
The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha subunit and a beta subunit that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha V subunit. This subunit associates with beta 1, beta 3, beta 5, beta 6 and beta 8 subunits. The heterodimer consisting of alpha V and beta 3 subunits is also known as the vitronectin receptor. This integrin may regulate angiogenesis and cancer progression. Alternative splicing results in multiple transcript variants. Note that the integrin alpha 5 and integrin alpha V subunits are encoded by distinct genes.
Ad fiber knob is expressed in adenovirus.
- Species Reactivity: Human, African Green Monkey, Rabbit, Bovine
- Type: IgG1, κ
- Application: FC, IHC-Fr, ICC, IP, ELISA, Depletion, BL, Adhesion
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For Research Use Only. Not For Clinical Use.