Anti-integrin alphaV-DM4 ADC (CAT#: ADC-140CL)

This ADC product is composed of an anti-integrin alphaV antibody conjugated via linker to DM4(anti-integrin alphaV-DM4). It has demonstrated a response in melanoma, sarcoma or carcinoma treatment by a MOA (Mechanism of Action) of microtubules depolymerizing.


Specific Inquiry
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Subcellular Location
Normal Tissue
RNA Expression

Specifications

  • Antibody Overview
  • Anti-integrin alphaV (intetumumab)
  • Drug
  • DM4 (N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine)
  • Drug Class/Description
  • Class: Maytansinoid
    Description: Maytansinoids are a group of cytotoxins structurally similar to rifamycin, geldanamycin, and ansatrienin. The eponymous natural cytotoxic agent maytansine is a 19-member lactam (ansa
    macrolide) structure originally isolated from the Ethiopian shrub Maytenus ovatus. Maytansinoids can bind to tubulin at or near the vinblastine-binding site, which interfere the formation of microtubules and depolymerize already formed microtubules, inducing mitotic arrest in the intoxicated cells.

Target

  • Introduction
  • This gene encodes a protein that is a member of the integrin superfamily. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein undergoes post-translational cleavage to yield disulfide-linked heavy and light chains that combine with multiple integrin beta chains to form different integrins. This protein has been shown to heterodimerize with beta 1, beta 3, beta 5, beta 6, and beta 8; the heterodimer of alpha v and beta 3 is the Vitronectin receptor. This protein interacts with several extracellular matrix proteins to mediate cell adhesion and may play a role in cell migration. It is proposed that this protein may regulate angiogenesis and cancer progression. Alternative splicing results in multiple transcript variants that encode different protein isoforms. Note that the integrin alpha 5 and integrin alpha V chains are produced by distinct genes. [provided by RefSeq, Jan 2015]
  • Alternative Names
  • ITGAV; integrin, alpha V; CD51; MSK8; VNRA; VTNR; integrin alpha-V; integrin alphaVbeta3; vitronectin receptor subunit alpha; antigen identified by monoclonal antibody L230; integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51);

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Recombinant Antibody

Human Antibody

CAT Product Name Application Type
TAB-076 Anti-Human CD51 Recombinant Antibody (Intetumumab) ELISA, FC, IP, FuncS, IF, Neut, ICC IgG1 - kappa

Humanized Antibody

CAT Product Name Application Type
TAB-H01 Anti-Human ITGAV Recombinant Antibody (Abituzumab) Inhib, Agonist IgG2 - kappa

Blocking Antibody

CAT Product Name Application Type
NEUT-1537CQ Recombinant Mouse Anti-ITGAV Antibody (272-17E6) Inhib, ICC/IF, BL, FC, ELISA, IP IgG1
NEUT-1577CQ Recombinant Mouse Anti-ITGAV Antibody (13C2) FC, IHC-Fr, ICC, IP, ELISA, Depletion, BL, Adhesion IgG1, κ
NEUT-1578CQ Recombinant Mouse Anti-ITGAV Antibody (NKI-M9) FC, IF, ELISA, BL, IP IgG2a, κ
NEUT-1579CQ Recombinant Mouse Anti-ITGAV Antibody (10D5) IP, FC, BL IgG2a
NEUT-1580CQ Recombinant Mouse Anti-ITGAV Antibody (27.1) ICC/IF, FC, IP, IHC-Fr, BL IgG1

Neutralizing Antibody

CAT Product Name Application Type
NEUT-1582CQ Recombinant Rat Anti-Itgav Antibody (RMV-7) FC, FuncS, IP, Neut IgG1, κ

Rabbit Monoclonal Antibody

ADCC Enhanced Antibody

CAT Product Name Application Type
AFC-TAB-076 Afuco™ Anti-ITGAV ADCC Recombinant Antibody (Intetumumab), ADCC Enhanced ELISA, FC, IP, FuncS, IF, Neut ADCC enhanced antibody
AFC-TAB-H01 Afuco™ Anti-ITGAV ADCC Recombinant Antibody (Abituzumab), ADCC Enhanced ELISA, IP, FC, FuncS, IF, Neut ADCC enhanced antibody

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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