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Anti-EDB Antibody-Cytokine Fusion Protein, scFv (L19)-IL4 (CAT#: ACFP-SH081)

This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-EDB scFv to IL4. It was expressed in CHO and purified with affinity chromatography. The immunocytokine retains the ability to bind the EDB as well as the biological activity of IL4. The fusion protein inhibits angiogenesis by targeting IL4 to sites of neovasculature in a patient. This immunocytokine was designed for treating Advanced solid tumors, Advanced pancreatic cancer, Metastatic melanoma.


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  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Normal Tissue
Figure 1 Cerebral cortex
Figure 1 Cerebral cortex
(Endothelial cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/126/2077_B_9_5.jpg
Figure 2 Colon
Figure 2 Colon
(Endothelial cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/126/2077_A_9_3.jpg
Figure 3 Liver
Figure 3 Liver
(Hepatocytes
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/126/2077_A_9_4.jpg
Figure 4 Testis
Figure 4 Testis
(Leydig cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/126/2077_A_5_6.jpg
Figure 5 Placenta
Figure 5 Placenta
(Decidual cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Trophoblastic cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/126/2077_A_1_7.jpg
Figure 6 Lymph node
Figure 6 Lymph node
(Germinal center cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/126/2077_A_7_8.jpg
RNA Expression
Figure 7 RNA cell line category: Cell line enhanced (ASC TERT1, HSkMC, hTERT-HME1, hTERT-RPE1)
Figure 7 RNA cell line category: Cell line enhanced (ASC TERT1, HSkMC, hTERT-HME1, hTERT-RPE1)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000115414-FN1

Specifications

  • Target
  • EDB
  • Molecule Class
  • scFv-IL4
  • Species Reactivity
  • Human
  • Expression Host
  • CHO
  • Clone
  • L19
  • Related Disease
  • Advanced solid tumors, Advanced pancreatic cancer, Metastatic melanoma
  • Cytokine 1
  • IL4
  • Cytokines 1 Description
  • The interleukin 4 (IL4) is a cytokine that induces differentiation of naive helper T cells (Th0 cells) to Th2 cells. Upon activation by IL-4, Th2 cells subsequently produce additional IL-4 in a positive feedback loop. The cell that initially produces IL-4, thus inducing Th0 differentiation, has not been identified, but recent studies suggest that basophils may be the effector cell. It is closely related and has functions similar to Interleukin 13.
  • Cytokine 1 Species
  • Mouse
  • Applications
  • This product can be used therapeutically to deliver biologically active ligands to a desired tissue.

Target

  • Alternative Names
  • FN; CIG; FNZ; MSF; ED-B; FINC; GFND; LETS; GFND2

Related Resources

  • Related Diseases

Downloads

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Recombinant Antibody

CAT Product Name Application Type
MOB-1294z Mouse Anti-FN1 Recombinant Antibody (clone 6H4) IHC, IP, WB Mouse IgG2b, κ
HPAB-1110-FY Human Anti-FN1 Recombinant Antibody (HPAB-1110-FY) IHC Human IgG
HPAB-1111-FY Human Anti-FN1 Recombinant Antibody (HPAB-1111-FY) IHC Human IgG
HPAB-1112-FY Human Anti-FN1 Recombinant Antibody (HPAB-1112-FY) IHC Human IgG
HPAB-1113-FY Human Anti-FN1 Recombinant Antibody (HPAB-1113-FY) IHC Human IgG

Human Antibody

CAT Product Name Application Type
TAB-001CQ Anti-Human FN1 Recombinant Antibody (MOR03255) ELISA, Block, IHC Human antibody
TAB-002CQ Anti-Human FN1 Recombinant Antibody (ME-4C) ELISA, IHC Human antibody
TAB-003CQ Anti-Human FN1 Recombinant Antibody (1C5) ELISA, WB Human antibody
TAB-004CQ Human Anti-FN1 Recombinant Antibody (TAB-004CQ) ELISA, IHC, WB Human IgG
TAB-071WM-F(E) Anti-Human FN1 Recombinant Antibody Fab Fragment (CGS-1) ELISA, WB Human Antibody

Blocking Antibody

CAT Product Name Application Type
NEUT-852CQ Mouse Anti-FN1 Recombinant Antibody (clone HFN7.1) ELISA, WB, IP, Block Mouse IgG1
NEUT-853CQ Mouse Anti-FN1 Recombinant Antibody (clone IST-9) WB, RIA, ELISA, IHC-Fr, ICC, IF, Block, IHC-P Mouse IgG1

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-1326 Hi-Affi™ Rabbit Anti-FN1 Recombinant Antibody (clone DS1326AB) IHC-Fr, IHC-P, IHC-P, IP, WB Rabbit IgG

Fab Fragment Antibody

CAT Product Name Application Type
HPAB-0193-CN-F(E) Mouse Anti-FN1 Recombinant Antibody; Fab Fragment (HPAB-0193-CN-F(E)) ELISA, FC, IHC Mouse Fab
HPAB-0194-CN-F(E) Mouse Anti-FN1 Recombinant Antibody; Fab Fragment (HPAB-0194-CN-F(E)) ELISA, FC, IHC Mouse Fab
HPAB-0195-CN-F(E) Human Anti-FN1 Recombinant Antibody; Fab Fragment (HPAB-0195-CN-F(E)) ELISA, FC, IHC Humanized Fab
HPAB-0196-CN-F(E) Human Anti-FN1 Recombinant Antibody; Fab Fragment (HPAB-0196-CN-F(E)) ELISA, FC, IHC Humanized Fab
HPAB-S0038-YC-F(E) Human Anti-FN1 Recombinant Antibody (clone L19); Fab Fragment ELISA, IF, IHC Human Fab

scFv Fragment Antibody

CAT Product Name Application Type
HPAB-1705-FY-F(E) Mouse Anti-FN1 Recombinant Antibody (clone MOR02610); scFv Fragment ELISA, IHC Mouse scFv
HPAB-1706-FY-F(E) Mouse Anti-FN1 Recombinant Antibody (clone MOR02611); scFv Fragment ELISA, IHC Mouse scFv
HPAB-1707-FY-F(E) Mouse Anti-FN1 Recombinant Antibody (clone MOR02613); scFv Fragment ELISA, IHC Mouse scFv
HPAB-S0037-YC-S(P) Human Anti-FN1 Recombinant Antibody (clone CGS-2); scFv Fragment ELISA, IB, IHC Human scFv
HPAB-S0038-YC-S(P) Human Anti-FN1 Recombinant Antibody (clone L19); scFv Fragment ELISA, IF, IHC Human scFv

Single-domain Antibody

CAT Product Name Application Type
NBD-0040-YJ-VHH Camelid Anti-FN1 Recombinant Single Domain Antibody (NJB2) ELISA, In vivo imaging Camelid VHH

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