Anti-EDB Antibody-Cytokine Fusion Protein, scFv (L19)-VEGF (CAT#: ACFP-SH082)

This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-EDB scFv to VEGF. It was expressed in CHO and purified with affinity chromatography. The immunocytokine retains the ability to bind the EDB as well as the biological activity of VEGF. The fusion protein showed accumulation in the tumor, and vasoactive immunoconjugates may improve MAb uptake in tumors significantly and therefore increase the therapeutic index of MAb-based therapy. This immunocytokine was designed for treating Advanced solid tumors, Advanced pancreatic cancer, Metastatic melanoma.


Specific Inquiry
  • Size:
  • Conjugation:
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Normal Tissue
RNA Expression

Specifications

  • Target
  • EDB
  • Molecule Class
  • scFv-VEGF
  • Species Reactivity
  • Human
  • Expression Host
  • CHO
  • Clone
  • L19
  • Related Disease
  • Advanced solid tumors, Advanced pancreatic cancer, Metastatic melanoma
  • Cytokine 1
  • VEGF
  • Cytokines 1 Description
  • Vascular endothelial growth factor (VEGF), originally known as vascular permeability factor (VPF), is a signal protein produced by cells that stimulatesvasculogenesis and angiogenesis. It is part of the system that restores the oxygen supply to tissues when blood circulation is inadequate such as in hypoxic conditions. Serum concentration of VEGF is high in bronchial asthma and diabetes mellitus. VEGF's normal function is to create new blood vessels duringembryonic development, new blood vessels after injury, muscle following exercise, and new vessels (collateral circulation) to bypass blocked vessels.
  • Cytokine 1 Species
  • Human
  • Applications
  • This product can be used therapeutically to deliver biologically active ligands to a desired tissue.

Target

  • Alternative Names
  • FN; CIG; FNZ; MSF; ED-B; FINC; GFND; LETS; GFND2

Related Resources

  • Related Diseases

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "Clone L19"

See other products for "FN1"

Human Antibody

CAT Product Name Application Type
TAB-001CQ Anti-Human FN1 Recombinant Antibody (MOR03255) ELISA, Block, IHC Human antibody
TAB-002CQ Anti-Human FN1 Recombinant Antibody (ME-4C) ELISA, IHC Human antibody
TAB-003CQ Anti-Human FN1 Recombinant Antibody (1C5) ELISA, WB Human antibody
TAB-004CQ Human Anti-FN1 Recombinant Antibody (TAB-004CQ) ELISA, IHC, WB Human IgG
TAB-071WM Anti-Human FN1 Recombinant Antibody (CGS-1) ELISA, WB Human Antibody

Blocking Antibody

CAT Product Name Application Type
NEUT-852CQ Mouse Anti-FN1 Recombinant Antibody (clone HFN7.1) ELISA, WB, IP, Block Mouse IgG1
NEUT-853CQ Mouse Anti-FN1 Recombinant Antibody (clone IST-9) WB, RIA, ELISA, IHC-Fr, ICC, IF, Block, IHC-P Mouse IgG1

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-1326 Hi-Affi™ Rabbit Anti-FN1 Recombinant Antibody (clone DS1326AB) IHC-Fr, IHC-P, IHC-P, IP, WB Rabbit IgG

Single-domain Antibody

CAT Product Name Application Type
NBD-0040-YJ-VHH Camelid Anti-FN1 Recombinant Single Domain Antibody (NJB2) ELISA, In vivo imaging Camelid VHH

Customer Reviews and Q&As

Submit a review or a question
There are currently no Customer reviews or questions for ACFP-SH082. Click the button above to contact us or submit your feedback about this product.
View the frequently asked questions answered by Creative Biolabs Support.

For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

Send Inquiry

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

© 2024 Creative Biolabs.
  • 0
  • 0
Cart

    Go to compare