Anti-EDB Antibody-Cytokine Fusion Protein, scFv (L19)-VEGF

Name: Anti-EDB Antibody-Cytokine Fusion Protein, scFv (L19)-VEGF
SKU: ACFP-SH082
Rating: 5 (1 reviews)

CAT#: ACFP-SH082

This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-EDB scFv to VEGF. It was expressed in CHO and purified with affinity chromatography. The immunocytokine retains the ability to bind the EDB as well as the biological activity of VEGF. The fusion protein showed accumulation in the tumor, and vasoactive immunoconjugates may improve MAb uptake in tumors significantly and therefore increase the therapeutic index of MAb-based therapy. This immunocytokine was designed for treating Advanced solid tumors, Advanced pancreatic cancer, Metastatic melanoma.

Gene Expression

Normal Tissue Figure 1 Cerebral cortex

Endothelial cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/126/2077_B_9_5.jpg

Normal Tissue Figure 2 Colon

Endothelial cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/126/2077_A_9_3.jpg

Normal Tissue Figure 3 Liver

Hepatocytes
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/126/2077_A_9_4.jpg

Normal Tissue Figure 4 Testis

Leydig cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/126/2077_A_5_6.jpg

Normal Tissue Figure 5 Placenta

Decidual cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Trophoblastic cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/126/2077_A_1_7.jpg

Normal Tissue Figure 6 Lymph node

Germinal center cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/126/2077_A_7_8.jpg

RNA Expression Figure 7 RNA cell line category: Cell line enhanced (ASC TERT1, HSkMC, hTERT-HME1, hTERT-RPE1)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000115414-FN1

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Specifications

Target
EDB

Molecule Class
scFv-VEGF

Species Reactivity
Human

Expression Host
CHO

Clone
L19

Related Disease
Advanced solid tumors, Advanced pancreatic cancer, Metastatic melanoma

Cytokine 1
VEGF

Cytokines 1 Description
Vascular endothelial growth factor (VEGF), originally known as vascular permeability factor (VPF), is a signal protein produced by cells that stimulatesvasculogenesis and angiogenesis. It is part of the system that restores the oxygen supply to tissues when blood circulation is inadequate such as in hypoxic conditions. Serum concentration of VEGF is high in bronchial asthma and diabetes mellitus. VEGF's normal function is to create new blood vessels duringembryonic development, new blood vessels after injury, muscle following exercise, and new vessels (collateral circulation) to bypass blocked vessels.

Cytokine 1 Species
Human

Applications
This product can be used therapeutically to deliver biologically active ligands to a desired tissue.

Target

Alternative Names
FN; CIG; FNZ; MSF; ED-B; FINC; GFND; LETS; GFND2

Gene ID
2335

UniProt ID
P02751

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Related Diseases

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Downloadable Resources

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Datasheet

Datasheet - ACFP-SH082.pdf

MSDS

MSDS - ACFP-SH082.pdf

COA

Certificate of Analysis Lookup

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