Anti-EDB Immunocytokine, scIL12-scFv-CH4 (L19) (ACFP-SH140)
This antibody-cytokine fusion protein was generated fusing scIL12-scFvL19 to the CH4 domain of the IgE heavy chain (IL12-SIP (L19)). It was expressed in CHO and purified with affinity chromatography. The immunocytokine retains the ability to bind the EDB as well as the biological activity of IL12. This immunocytokine was designed for treating Advanced solid tumors, Advanced pancreatic cancer, Metastatic melanoma.
Specifications
- Target
- EDB
- Molecule Class
- scIL12-scFv-CH4
- Species Reactivity
- Human
- Host
- Human
- Expression Host
- CHO
- Clone
- L19
- Related Disease
- Advanced solid tumors, Advanced pancreatic cancer, Metastatic melanoma
- Cytokines 1
- IL12
- Cytokines 1 Description
- Interleukin 12 (IL-12) is an interleukin that is naturally produced by dendritic cells, macrophages, neutrophils, and human B-lymphoblastoid cells (NC-37) in response to antigenic stimulation. IL-12 is composed of a bundle of four alpha helices. It is a heterodimeric cytokine encoded by two separate genes, IL-12A (p35) and IL-12B (p40). The active heterodimer (referred to as 'p70'), and a homodimer of p40 are formed following protein synthesis.
- Cytokine 1 Species
- Human
- Applications
- This product can be used therapeutically to deliver biologically active ligands to a desired tissue.
Target
- Alternative Names
- FN; CIG; FNZ; MSF; ED-B; FINC; GFND; LETS
- Entrez Gene ID
- 2335
- UniProt ID
- P02751
For lab research use only, not for diagnostic, therapeutic or any in vivo human use.
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