Anti-FGFR3 immunotoxin (scFv)-Gel
CAT#: AGTO-G028G
This immunotoxin was achieved by conjugating/fusing the Anti-FGFR3 scFv to gelonin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to bladder carcinoma cells. Once bind, the toxin enters cells by receptor-mediated endocytosis. Then, gelonin, like abrin and ricin, inhibits protein synthesis by damaging the 60S subunit of mammalian ribosomes. It was designed for treating bladder carcinoma .
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to endoplasmic reticulum.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/67204/1419_D10_2_selected.jpg
Subcellular Location
Figure 2 IF staining of human cell line RT4
Immunofluorescent staining of human cell line RT4 shows localization to endoplasmic reticulum.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/67204/1382_D10_2_blue_green.jpg
Normal Tissue
Figure 3 Cerebral cortex
Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Glial cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Neuronal cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
Neuropil
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4231/11838_B_7_5.jpg
Normal Tissue
Figure 4 Testis
Spermatogonia cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4231/11838_A_6_6.jpg
Normal Tissue
Figure 5 Skin
Cells in basal layer
Staining: High
Intensity: Strong
Quantity:>75%
Cells in spinous layer
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Langerhans cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4231/11838_B_8_1.jpg
RNA Expression
Figure 6 RNA cell line category: Cell line enhanced (CACO-2, HaCaT, Hep G2, NTERA-2, RT4)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000068078-FGFR3
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Specifications
- Host Species
- Mouse
- Species Reactivity
- Human
- Molecule Class
- scFv-Gel
- Toxin Description
- Gelonin is a glycoprotein (M.W. approximately 29-30,000 Kd) purified from the seeds of Gelonium multiforum and belongs to a class of potent ribosomal-inactivating plant toxins. Gelonin, like abrin and ricin, inhibits protein synthesis by damaging the 60S subunit of mammalian ribosomes.
- Applications
- This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
- Related Disease
- bladder carcinoma
Target
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Related Diseases
Bladder Cancer
EGFR Tyrosine Kinase Inhibitor Resistance
Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| AGTO-G028E | Anti-FGFR3 immunotoxin (scFv)-PE | Cytotoxicity assay, Function study | |
| AGTO-L016E | aFGF-PE immunotoxin | Cytotoxicity assay, Functional assay | |
| AGTO-L016G | aFGF-Gel immunotoxin | Cytotoxicity assay, Functional assay |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBL-471 | Human Anti-FGFR3 Recombinant Antibody (clone R3Mab); Fab Fragment | ELISA | Human Fab |
| HPAB-0157-YC-F(E) | Human Anti-FGFR3 Recombinant Antibody; Fab Fragment (HPAB-0157-YC-F(E)) | ELISA, IP, WB | Human Fab |
| HPAB-0158-YC-F(E) | Mouse Anti-FGFR3 Recombinant Antibody; Fab Fragment (HPAB-0158-YC-F(E)) | ELISA, FC | Mouse Fab |
| HPAB-0159-YC-F(E) | Human Anti-FGFR3 Recombinant Antibody (clone Antibody 1); Fab Fragment | ELISA, FuncS | Human Fab |
| HPAB-0160-YC-F(E) | Human Anti-FGFR3 Recombinant Antibody (clone PRO-001); Fab Fragment | FC, FuncS | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBL-471 | Human Anti-FGFR3 Recombinant Antibody (clone R3Mab); scFv Fragment | ELISA | Human scFv |
| HPAB-0157-YC-S(P) | Human Anti-FGFR3 Recombinant Antibody; scFv Fragment (HPAB-0157-YC-S(P)) | ELISA, IP, WB | Human scFv |
| HPAB-0158-YC-S(P) | Mouse Anti-FGFR3 Recombinant Antibody; scFv Fragment (HPAB-0158-YC-S(P)) | ELISA, FC | Mouse scFv |
| HPAB-0159-YC-S(P) | Human Anti-FGFR3 Recombinant Antibody (clone Antibody 1); scFv Fragment | ELISA, FuncS | Human scFv |
| HPAB-0150-WJ-S(P) | Human Anti-FGFR3 Recombinant Antibody; scFv Fragment (HPAB-0150-WJ-S(P)) | ELISA | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-062WM | Mouse Anti-FGFR3 Recombinant Antibody (TAB-062WM) | ELISA, FC, Neut, WB | Mouse IgG |
| TAB-063WM | Mouse Anti-FGFR3 Recombinant Antibody (TAB-063WM) | ELISA, FC, Neut, WB | Mouse IgG |
| TAB-062WM-S(P) | Mouse Anti-FGFR3 Recombinant Antibody; scFv Fragment (TAB-062WM-S(P)) | ELISA, FC, Neut, WB | Mouse scFv |
| TAB-063WM-S(P) | Mouse Anti-FGFR3 Recombinant Antibody; scFv Fragment (TAB-063WM-S(P)) | ELISA, FC, Neut, WB | Mouse scFv |
| TAB-064WM-S(P) | Anti-Human FGFR3 Recombinant Antibody scFv Fragment (15D8) | Neut, ELISA |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0738CT | Recombinant Mouse anti-Human FGFR3 Monoclonal antibody (NN0380-7H22) | IHC-P, WB | |
| ZG-0667J | Rabbit Anti-FGFR3 Recombinant Antibody (clone 5B6) | ELISA, IF | Rabbit IgG |
| ZG-0668J | Rabbit Anti-FGFR3 Recombinant Antibody (clone 6D4) | ELISA, WB | Rabbit IgG |
| VS3-FY549 | Recombinant Rabbit Anti-FGFR3 Antibody (clone R06-6F4) | WB, IHC-Fr, IHC-P, ICC, IF | Rabbit IgG |
| VS3-FY2003 | Rabbit Anti-FGFR3 Recombinant Antibody (clone R03-2C7) | WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-834CQ | Mouse Anti-FGFR3 Recombinant Antibody (clone CBL546) | Neut | Mouse IgG1 |
| NEUT-835CQ | Mouse Anti-FGFR3 Recombinant Antibody (clone CBL547) | WB, Neut | Mouse IgG1 |
| NEUT-836CQ | Mouse Anti-FGFR3 Recombinant Antibody (clone 6G11) | WB, Neut | Mouse IgG1 |
| NEUT-837CQ | Mouse Anti-FGFR3 Recombinant Antibody (clone CBL061) | WB, IHC, Neut | Mouse IgG1 |
| NEUT-838CQ | Rat Anti-Fgfr3 Recombinant Antibody (clone CBL548) | Neut | Rat IgG2a |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1299 | Hi-Affi™ Rabbit Anti-FGFR3 Recombinant Antibody (clone DS1299AB) | WB, IHC, ICC, FC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY838 | Anti-FGFR3 Immunohistochemistry Kit | IHC | |
| VS-0525-XY2544 | Anti-Mouse FGFR3 Immunohistochemistry Kit | IHC | |
| VS-0525-XY2543 | Anti-Human FGFR3 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC387 | Recombinant Anti-FGFR3 Vesicular Antibody, EV Displayed (VS-0425-YC387) | ELISA, FC, Neut, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-YC82 | Recombinant Anti-FGFR3 (Domain 2 x Domain 3c) Biparatopic Antibody, Tandem scFv (Clone PRO-001 x Clone PRO-055) | FC | Tandem scFv |
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