Anti-FGFR3 immunotoxin (scFv)-Gel (CAT#: AGTO-G028G)
This immunotoxin was achieved by conjugating/fusing the Anti-FGFR3 scFv to gelonin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to bladder carcinoma cells. Once bind, the toxin enters cells by receptor-mediated endocytosis. Then, gelonin, like abrin and ricin, inhibits protein synthesis by damaging the 60S subunit of mammalian ribosomes. It was designed for treating bladder carcinoma .
We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.

(Immunofluorescent staining of human cell line U-2 OS shows localization to endoplasmic reticulum.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/67204/1419_D10_2_selected.jpg

(Immunofluorescent staining of human cell line RT4 shows localization to endoplasmic reticulum.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/67204/1382_D10_2_blue_green.jpg

(Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Glial cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Neuronal cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
Neuropil
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4231/11838_B_7_5.jpg

(Spermatogonia cells
Staining: Medium
Intensity: Moderate
Quantity:>75%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4231/11838_A_6_6.jpg

(Cells in basal layer
Staining: High
Intensity: Strong
Quantity:>75%
Cells in spinous layer
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Langerhans cells
Staining: Medium
Intensity: Moderate
Quantity:>75%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4231/11838_B_8_1.jpg

(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000068078-FGFR3

(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000068078-FGFR3
Specifications
- Host Species
- Mouse
- Species Reactivity
- Human
- Molecule Class
- scFv-Gel
- Toxin Description
- Gelonin is a glycoprotein (M.W. approximately 29-30,000 Kd) purified from the seeds of Gelonium multiforum and belongs to a class of potent ribosomal-inactivating plant toxins. Gelonin, like abrin and ricin, inhibits protein synthesis by damaging the 60S subunit of mammalian ribosomes.
- Applications
- This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
- Related Disease
- bladder carcinoma
Target
- Alternative Names
- FGFR3; fibroblast growth factor receptor 3; ACH; CEK2; JTK4; CD333; HSFGFR3EX; FGFR-3; tyrosine kinase JTK4; hydroxyaryl-protein kinase; fibroblast growth factor receptor 3 variant 4; Gelonin; Gel
- Gene ID
- 2261
- UniProt ID
- P22607
Related Resources
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "FGFR3"
Select a product category from the dropdown menu below to view related products.
CAT | Product Name | Application | Type |
---|---|---|---|
AGTO-G028E | Anti-FGFR3 immunotoxin (scFv)-PE | Cytotoxicity assay, Function study | |
AGTO-L016E | aFGF-PE immunotoxin | Cytotoxicity assay, Functional assay | |
AGTO-L016G | aFGF-Gel immunotoxin | Cytotoxicity assay, Functional assay |
Customer Reviews and Q&As
There are currently no Customer reviews or questions for AGTO-G028G. Click the button above to contact us or submit your feedback about this product.
Popular products with customers
Application: FC, Cyt, Stim, PP, Agonist
Application: WB, IF, IP, Neut, FuncS, ELISA, FC
Application: ELISA, IP, FC, FuncS, Neut, IF, ICC
Application: FuncS, IF, Neut, ELISA, FC, IP, IHC
Application: FC, IP, ELISA, Neut, FuncS, IF, WB
Application: Neut, ELISA, IF, IP, FuncS, FC, WB
Application: IP, IF, FuncS, FC, Neut, ELISA, IHC
Application: FC, IP, ELISA, Neut, FuncS, IF, IHC
Application: ELISA
Application: ELISA
Application: ELISA, Inhib, FC
Application: WB, ELISA
Application: WB, ELISA, IF, FuncS, Apop, BA
Application: ELISA, IHC, FC, IP, IF, Inhib
For Research Use Only. Not For Clinical Use.
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.