Anti-FGFR3 immunotoxin (scFv)-Gel (AGTO-G028G)
This immunotoxin was achieved by conjugating/fusing the Anti-FGFR3 scFv to gelonin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to bladder carcinoma cells. Once bind, the toxin enters cells by receptor-mediated endocytosis. Then, gelonin, like abrin and ricin, inhibits protein synthesis by damaging the 60S subunit of mammalian ribosomes. It was designed for treating bladder carcinoma .
Specifications
- Host
- Mouse
- Species Reactivity
- Human
- Molecule Class
- scFv-Gel
- Toxin Description
- Gelonin is a glycoprotein (M.W. approximately 29-30,000 Kd) purified from the seeds of Gelonium multiforum and belongs to a class of potent ribosomal-inactivating plant toxins. Gelonin, like abrin and ricin, inhibits protein synthesis by damaging the 60S subunit of mammalian ribosomes.
- Applications
- This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
- Related Disease
- bladder carcinoma
Target
- Alternative Names
- FGFR3; fibroblast growth factor receptor 3; ACH; CEK2; JTK4; CD333; HSFGFR3EX; FGFR-3
- Entrez Gene ID
- 2261
- UniProt ID
- P22607
For lab research use only, not for diagnostic, therapeutic or any in vivo human use.
Our customer service representatives are available 24 hours a day, from Monday to Sunday. Contact Us
Tel: 1-631-381-2994
Fax: 1-631-207-8356
Email: