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Anti-FGFR3 immunotoxin (scFv)-Gel (AGTO-G028G)

This immunotoxin was achieved by conjugating/fusing the Anti-FGFR3 scFv to gelonin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to bladder carcinoma cells. Once bind, the toxin enters cells by receptor-mediated endocytosis. Then, gelonin, like abrin and ricin, inhibits protein synthesis by damaging the 60S subunit of mammalian ribosomes. It was designed for treating bladder carcinoma .      
  • Datasheet

Specifications
Host
Mouse
Species Reactivity
Human
Molecule Class
scFv-Gel
Toxin Description
Gelonin is a glycoprotein (M.W. approximately 29-30,000 Kd) purified from the seeds of Gelonium multiforum and belongs to a class of potent ribosomal-inactivating plant toxins. Gelonin, like abrin and ricin, inhibits protein synthesis by damaging the 60S subunit of mammalian ribosomes.
Applications
This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
Related Disease
bladder carcinoma
Target
Alternative Names
FGFR3; fibroblast growth factor receptor 3; ACH; CEK2; JTK4; CD333; HSFGFR3EX; FGFR-3
Entrez Gene ID
2261
UniProt ID
P22607

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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