Recombinant Anti-FGFR3 Vesicular Antibody, EV Displayed (VS-0425-YC387)

Name: Recombinant Anti-FGFR3 Vesicular Antibody, EV Displayed (VS-0425-YC387)
SKU: VS-0425-YC387
Rating: 5 (1 reviews)

CAT#: VS-0425-YC387

The Recombinant Anti-FGFR3 Vesicular Antibody, EV Displayed (VS-0425-YC387) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to FGFR3-expressed cells or tissues. The FGFR3 is a fibroblast growth factor receptor involved in bone development and cell differentiation, with mutations leading to craniosynostosis and skeletal dysplasia.

Gene Expression

Subcellular Location Figure 1 IF staining of human cell line U-2 OS

Immunofluorescent staining of human cell line U-2 OS shows localization to endoplasmic reticulum.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/67204/1419_D10_2_selected.jpg

Subcellular Location Figure 2 IF staining of human cell line RT4

Immunofluorescent staining of human cell line RT4 shows localization to endoplasmic reticulum.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/67204/1382_D10_2_blue_green.jpg

Normal Tissue Figure 3 Cerebral cortex

Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Glial cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Neuronal cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
Neuropil
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4231/11838_B_7_5.jpg

Normal Tissue Figure 4 Testis

Spermatogonia cells
Staining: Medium
Intensity: Moderate
Quantity:>75%

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4231/11838_A_6_6.jpg

Normal Tissue Figure 5 Skin

Cells in basal layer
Staining: High
Intensity: Strong
Quantity:>75%
Cells in spinous layer
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Langerhans cells
Staining: Medium
Intensity: Moderate
Quantity:>75%

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4231/11838_B_8_1.jpg

RNA Expression Figure 6 RNA cell line category: Cell line enhanced (CACO-2, HaCaT, Hep G2, NTERA-2, RT4)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000068078-FGFR3

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Recombinant Antibody

Application
ELISA, FC, Neut, Cell-uptake

Product Type
Ab-Fc-EVs

Antibody Quantification (Ab/EV)
~100 Ab/EV

Target
FGFR3

Host Animal
Human

Antibody Isotype
IgG

Species Reactivity
Human

Expression Cell
Mammalian cell

Engineered EVs

EV-sorting domain
CD63

Fc-binding domain
z domain

EV Size
30~150 nm

Producing Cell
HEK293F

Isolation Method
Gradient centrifugation

Purification
qEV size exclusion chromatography

Binding Affinity
Kd = 0.85 µg/mL

Concentration
1 x 10¹⁰

Size
1 mL

Buffer
PBS

Storage
Store at -80°C for 12 months

Target

Full Name
Fibroblast growth factor receptor 3

Biological Process
Apoptosis

Molecular Function
Kinase, Receptor, Transferase, Tyrosine-protein kinase

Cellular Localization
Endoplasmic reticulum

Introduction
This gene encodes a member of the fibroblast growth factor receptor (FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in this gene lead to craniosynostosis and multiple types of skeletal dysplasia.

Alternative Names
ACH, CD333, CEK2, JTK4

Gene ID
2261

UniProt ID
P22607

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Related Diseases

Bladder Cancer

EGFR Tyrosine Kinase Inhibitor Resistance

Downloadable Resources

Download resources about recombinant antibody development and antibody engineering to boost your research.

Datasheet

Datasheet - VS-0425-YC387.pdf

MSDS

MSDS - VS-0425-YC387.pdf

COA

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