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    FGFR3

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    Anti-FGFR3 Recombinant Antibody Products

    • aFGF-PE immunotoxin (AGTO-L016E)
      • Species Reactivity: Human
      • Application: Cytotoxicity assay, Functional assay
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    • aFGF-Gel immunotoxin (AGTO-L016G)
      • Species Reactivity: Human
      • Application: Cytotoxicity assay, Functional assay
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    For Research Use Only. Not For Clinical Use.


    Creative Biolabs provides a varied selection of highly potent anti-FGFR3 recombinant antibodies, precisely produced for use in a variety of immunological tests. These antibodies are developed to be extremely precise and specific, allowing researchers to confidently examine the involvement of FGFR3 in a variety of biological pathways.

    FGFR3: An Important Target for Cancer Treatment

    FGFR-3 is a member of the fibroblast growth factor receptor family, characterized by a highly conserved amino acid sequence across species. This receptor binds to both acidic and basic fibroblast growth hormones and plays a key role in bone formation and maintenance. Recent studies have identified aberrant FGFR-3 expression in various diseases and cancers, including achondroplasia, bladder cancer, multiple myeloma, and cervical cancer. Consequently, targeting FGFR-3 represents a promising avenue for therapeutic intervention in these conditions.

    Alternative Names

    Fibroblast growth factor receptor 3; FGFR-3; hydroxyaryl-protein kinase; ACH; CD333; CEK2; HSFGFR3EX; tyrosine kinase JTK4; JTK4; HBGFR.

    Background

    This gene encodes a member of the fibroblast growth factor receptor (FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in this gene lead to craniosynostosis and multiple types of skeletal dysplasia.

    Anti-FGFR3 Recombinant Antibody Products

    Creative Biolabs offers a wide spectrum of recombinant antibodies that target FGFR3, each expertly tailored for accurate identification and neutralization. These antibodies are available in a number of forms and have outstanding specificity and affinity, making them ideal for a wide range of applications.

    Table 1. Featured anti-FGFR3 recombinant antibody products at Creative Biolabs.

    Cat. No. Product Name Target Species Host Species Applications
    PABL-474 Human Anti-FGFR3 Recombinant Antibody (clone R3Mab) Human Human IgG ELISA
    TAB-064WM Anti-Human FGFR3 Recombinant Antibody (15D8) Human Mouse Neut, ELISA
    HPAB-0160-YC Human Anti-FGFR3 Recombinant Antibody (clone PRO-001) Human, Mouse Human IgG FC, FuncS
    VS3-FY2003 Rabbit Anti-FGFR3 Recombinant Antibody (clone R03-2C7) Human, Mouse, Rat Rabbit IgG WB
    HPAB-0157-YC Human Anti-FGFR3 Recombinant Antibody (HPAB-0157-YC) Human Human IgG ELISA, IP, WB

    Creative Quality Control

    Creative Biolabs is a leading provider of precise anti-FGFR3 recombinant antibodies for cutting-edge research. We produce antibodies with exceptional qualities by integrating complex biotechnological methods with tight quality control. Our skilled scientists are committed to offering trustworthy solutions that support your research goals, covering everything from fundamental biology to medication development.

    Fig.1 SDS-PAGE analysis. (Creative Biolabs Original)Fig.1 SDS-PAGE analysis of anti-FGFR3 antibody
    (Cat# PABL-474, Creative Biolabs).

    Fig.2 WB analysis. (Creative Biolabs Original)Fig.2 WB analysis of anti-FGFR3 antibody
    (Cat# PABL-474, Creative Biolabs).

    Fig.3 WB analysis. (Creative Biolabs Original)Fig.3 WB analysis of anti-FGFR3 antibody
    (Cat# VS3-FY2003, Creative Biolabs).

    Fig.4 WB analysis. (Creative Biolabs Original)Fig.4 WB analysis of anti-FGFR3 antibody
    (Cat# VS3-FY2003, Creative Biolabs).

    Fig.5 ELISA analysis. (Creative Biolabs Original)Fig.5 ELISA analysis of anti-FGFR3 antibody
    (Cat# TAB-064WM, Creative Biolabs).

    Fig.6 Dot Blot analysis. (Creative Biolabs Original)Fig.6 Dot Blot analysis of anti-FGFR3 antibody
    (Cat# TAB-064WM, Creative Biolabs).

    Customer Reviews

    Excellent
    Ze***n
    Human Anti-FGFR3 Recombinant Antibody (clone R3Mab) (CAT#: PABL-474)
    I've been utilizing Creative Biolabs' anti-FGFR3 recombinant antibody in Western blot research and am quite pleased with its performance. Despite low protein concentrations, the antibody dependably provides distinct and specific bands. The excellent sensitivity and specificity have been useful in my study, allowing me to precisely quantify FGFR3 expression across several cell lines. I strongly suggest this antibody to anyone dealing with FGFR3.
    15/Oct/2022
    Excellent
    La***h
    Rabbit Anti-FGFR3 Recombinant Antibody (clone R03-2C7) (CAT#: VS3-FY2003)
    Creative Biolabs' anti-FGFR3 recombinant antibody has become an essential tool in my FGFR3 research. The antibody's high affinity and specificity allow me to detect and quantify FGFR3 expression with confidence. I've used it successfully in both Western blot and ELISA assays, and it has consistently delivered reliable results. If you're working with FGFR3, I highly recommend this antibody.
    22/Feb/2023
    Excellent
    Bo***e
    Anti-Human FGFR3 Recombinant Antibody (15D8) (CAT#: TAB-064WM)
    I recently acquired Creative Biolabs' anti-FGFR3 recombinant antibody for neutralization experiments and couldn't be more pleased with the findings. The antibody behaved admirably in my studies, with consistent and reproducible results. Additionally, Creative Biolabs' customer support team was really helpful and quick. They gave outstanding technical assistance and instruction, allowing me to utilize the antibody efficiently. I'd definitely order from them again.
    11/Mar/2024

    Anti-FGFR3 Recombinant Antibody Production

    Creative Biolabs employs cutting-edge recombinant antibody manufacturing technology designed exclusively for producing anti-FGFR3 antibodies. Our novel genetic engineering technologies enable the quick and high-quality synthesis of antibodies, ensuring a constant and trustworthy supply for all of your research requirements.

    Featured Anti-FGFR3 Recombinant Antibody Production Platforms Fig.7 Milligram-scale. (Creative Biolabs Original)
    Fig.7 Milligram-scale anti-FGFR3 recombinant antibody production.

    Fig.8 Gram-scale. (Creative Biolabs Original)Fig.8 Gram-scale anti-FGFR3 recombinant antibody production.

    Anti-FGFR3 Recombinant Antibody Modalities

    Creative Biolabs provides a wide choice of superior anti-FGFR3 recombinant antibodies customized to the unique requirements of researchers worldwide. Our antibodies are offered in a variety of forms, guaranteeing flexibility and efficacy across a broad range of scientific uses.

    Fig.9 FGFR3 antibody production and modalities. (Creative Biolabs Original)Fig.9 Full-length anti-FGFR3 recombinant antibody production and modalities.

    FGFR3-Targeted Drug Information

    Public Drug Information Targeting FGFR3

    Table 2. Public drug targeting FGFR3.

    Company Research Phase Classification Condition
    Novartis Europharm Limited
    Novartis Farma S.P.A.
    Novartis     		Approved, Phase IV Kinase Inhibitor Advanced renal cell carcinoma
    Advanced soft tissue sarcoma
    Advanced thyroid cancer
    Ariad Pharmaceuticals
    Incyte Biosciences Distribution B.V.
    Takeda Pharma A/S     		Approved, Phase III Kinase Inhibitor Accelerated phase chronic myeloid leukemia
    Acute lymphoblastic leukemia
    Chronic phase chronic myeloid leukemia
    Blast phase chronic myeloid leukemia
    Eisai Limited Approved, Phase IV Kinase Inhibitor Differentiated Thyroid Cancer (DTC)
    Renal Cell Carcinoma (RCC)
    Hepatocellular Carcinoma (HCC)
    Endometrial Carcinoma
    Eugia Pharma (Malta) Limited
    Accord Healthcare, S.L.U.
    Boehringer Ingelheim
    Boehringer Ingelheim Pharmaceuticals, Inc.     		Approved, Phase IV Antifibrotic Agents
    Kinase Inhibitor     		Decreased pulmonary function
    Idiopathic pulmonary fibrosis
    Chronic progressive fibrosing interstitial lung disease
    Locally advanced non-small cell lung carcinoma (nsclc)
    Incyte Biosciences Distribution B.V.
    Incyte Corporation     		Approved, Phase III Kinase Inhibitor Refractory myeloid/lymphoid neoplasms with fgfr1 rearrangement
    Unresectable, locally advanced cholangiocarcinomas
    Qed Therapeutics, Inc. Approved, Phase III Kinase Inhibitor Advanced bile duct cancer in adults
    Taiho Pharma Netherlands Bv
    Taiho Pharmaceutical Co., Ltd.     		Approved, Phase III Kinase Inhibitor Intrahepatic cholangiocarcinoma in previously treated adults

    (Disclaimer: The information in this table is just for knowledge sharing and not for marketing or sales purposes.)

    At Creative Biolabs, we are committed to providing exceptional customer service and high-quality anti-FGFR3 recombinant antibodies. Our team of professionals is committed to helping you pick the best antibodies for your individual requirements and ensuring your total satisfaction. Contact us today to find out how our products and services may help you reach your research goals.

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