Anti-FOLR1 (Mirvetuximab)-sulfo-SPDB-DM4 ADC (IMGN853)
CAT#: ADC-L018
This ADC product is composed of an anti-FOLR1 antibody (Mirvetuximab) conjuagated via a sulfo-SPDB linker to DM4 (Mirvetuximab-sulfo-SPDB-DM4). It has demonstrated a response in ovarian cancer, solid tumor treatment by a MOA (Mechanism of Action) of Depolymerize Microtubules.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line HeLa
Immunofluorescent staining of human cell line HeLa shows localization to nuclear membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/77030/1659_B3_2_selected.jpg
RNA Expression
Figure 2 RNA cell line category: Group enriched (HeLa, RPTEC TERT1)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000110195-FOLR1
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Specifications
- Antibody Overview
- Murine/human chimeric FOLR1-specific monoclonal IgG1k antibody mirvetuximab
- Clone
- Mirvetuximab
- Antibody Conjugation
- Chimeric murine/human
- Linker
- sulfo-SPDB (sulfosuccinimidyl N-succinimidyl-4-(2-pyridyldithio)butyrate)
- Linker Class/Description
- Class: Chemically cleavable linkers-Disulfide Linkers
Description: Disulfide Linkers are extensively exploited as a chemically labile linkage. Since the release of disulfide-linked drugs requires a cytoplasmic thiol cofactor, such as glutathione (GSH). Disulfides maintain stable at physiological pH and only when ADCs are internalized inside cells, the cytosol provides reducing environment including intracellular enzyme protein disulfide isomerase, or similar enzymes, drugs can be released.
- Drug
- DM4 (N2'-Deacetyl-N2'-(4-mercapto-4- methyl-1-oxopentyl)maytansine)
- Drug Class/Description
- Class: Maytansinoid
Description: Maytansinoids are a group of cytotoxins structurally similar to rifamycin, geldanamycin, and ansatrienin. The eponymous natural cytotoxic agent maytansine is a 19-member lactam (ansa
macrolide) structure originally isolated from the Ethiopian shrub Maytenus ovatus. Maytansinoids can bind to tubulin at or near the vinblastine-binding site, which interfere the formation of microtubules and depolymerize already formed microtubules, inducing mitotic arrest in the intoxicated cells.
Target
- Introduction
- The protein encoded by this gene is a member of the folate receptor family. Members of this gene family bind folic acid and its reduced derivatives, and transport 5-methyltetrahydrofolate into cells. This gene product is a secreted protein that either anchors to membranes via a glycosyl-phosphatidylinositol linkage or exists in a soluble form. Mutations in this gene have been associated with neurodegeneration due to cerebral folate transport deficiency. Due to the presence of two promoters, multiple transcription start sites, and alternative splicing, multiple transcript variants encoding the same protein have been found for this gene.
- Alternative Names
- FBP; FOLR
- Gene ID
- 2348
- UniProt ID
- P15328
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Datasheet
MSDS
COA
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| CAT | Product Name | Application | Type |
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| TAB-113 | Anti-Human folate receptor 1 Recombinant Antibody (TAB-113) | FC, IP, ELISA, Neut, FuncS, IF, ICC | IgG1 - kappa |
| TAB-019CQ | Human Anti-FOLR1 Recombinant Antibody (TAB-019CQ) | ELISA, WB, IHC | Human IgG1, κ |
| TAB-019CQ-S(P) | Human Anti-FOLR1 Recombinant Antibody; scFv Fragment (TAB-019CQ-S(P)) | ELISA, WB, IHC | Human scFv |
| TAB-019CQ-F(E) | Human Anti-FOLR1 Recombinant Antibody; Fab Fragment (TAB-019CQ-F(E)) | ELISA, WB, IHC | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-016CQ | Human Anti-FOLR1 Recombinant Antibody (TAB-016CQ) | ELISA, FC, WB | Human IgG |
| TAB-016CQ-S(P) | Human Anti-FOLR1 Recombinant Antibody; scFv Fragment (TAB-016CQ-S(P)) | ELISA, FC, WB | Human scFv |
| TAB-016CQ-F(E) | Human Anti-FOLR1 Recombinant Antibody; Fab Fragment (TAB-016CQ-F(E)) | ELISA, FC, WB | Human Fab |
| TAB-382CQ | Anti-Human FOLR1 Recombinant Antibody (TAB-382CQ) | IHC | Human antibody |
| TAB-382CQ-S(P) | Anti-Human FOLR1 Recombinant Antibody scFv Fragment (TAB-382CQ-S(P)) | IHC | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-017CQ | Rat Anti-FOLR1 Recombinant Antibody (TAB-017CQ) | ELISA, WB, IHC | Rat IgG1, κ |
| TAB-020CQ | Mouse Anti-FOLR1 Recombinant Antibody (TAB-020CQ) | ELISA, FC, WB, IHC | Mouse IgG1 |
| TAB-017CQ-S(P) | Rat Anti-FOLR1 Recombinant Antibody; scFv Fragment (TAB-017CQ-S(P)) | ELISA, WB, IHC | Rat scFv |
| TAB-020CQ-S(P) | Mouse Anti-FOLR1 Recombinant Antibody; scFv Fragment (TAB-020CQ-S(P)) | ELISA, FC, WB, IHC | Mouse scFv |
| TAB-017CQ-F(E) | Rat Anti-FOLR1 Recombinant Antibody; Fab Fragment (TAB-017CQ-F(E)) | ELISA, WB, IHC | Rat Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-018CQ | Human Anti-FOLR1 Recombinant Antibody (TAB-018CQ) | ELISA, WB, IHC | Chimeric (Rat/Human) IgG1, κ |
| TAB-018CQ-S(P) | Human Anti-FOLR1 Recombinant Antibody; scFv Fragment (TAB-018CQ-S(P)) | ELISA, WB, IHC | Human scFv |
| TAB-018CQ-F(E) | Human Anti-FOLR1 Recombinant Antibody; Fab Fragment (TAB-018CQ-F(E)) | ELISA, WB, IHC | Chimeric (Rat/Human) Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-029LC | Recombinant Anti-Human FOLR1 Antibody (Fc glycosylation/Non fucosylated) | ELISA | Human antibody |
| Gly-030LC | Recombinant Anti-Human FOLR1 Antibody (Fc glycosylation) | ELISA | Human antibody |
| Gly-116LC | Recombinant Anti-Human FOLR1 Antibody (Fc glycosylation) | ELISA | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-029LC-1 | Recombinant Anti-Human FOLR1 Antibody (Fc glycosylation/Non fucosylated) | ELISA | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1333 | Hi-Affi™ Rabbit Anti-FOLR1 Recombinant Antibody (clone DS1333AB) | WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0115-CN | Mouse Anti-FOLR1 Recombinant Antibody (HPAB-0115-CN) | ELISA, FC, IHC | Mouse IgG2b |
| HPAB-0116-CN | Human Anti-FOLR1 Recombinant Antibody (HPAB-0116-CN) | ELISA, FC, IHC | Humanized IgG1 |
| HPAB-0117-CN | Mouse Anti-FOLR1 Recombinant Antibody (HPAB-0117-CN) | ELISA, FC | Mouse IgG |
| HPAB-0118-CN | Mouse Anti-FOLR1 Recombinant Antibody (HPAB-0118-CN) | ELISA, FC | Mouse IgG |
| HPAB-0119-CN | Mouse Anti-FOLR1 Recombinant Antibody (HPAB-0119-CN) | ELISA, FC, IHC, WB | Mouse IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0115-CN-S(P) | Mouse Anti-FOLR1 Recombinant Antibody; scFv Fragment (HPAB-0115-CN-S(P)) | ELISA, FC, IHC | Mouse scFv |
| HPAB-0116-CN-S(P) | Human Anti-FOLR1 Recombinant Antibody; scFv Fragment (HPAB-0116-CN-S(P)) | ELISA, FC, IHC | Humanized scFv |
| HPAB-0117-CN-S(P) | Mouse Anti-FOLR1 Recombinant Antibody; scFv Fragment (HPAB-0117-CN-S(P)) | ELISA, FC | Mouse scFv |
| HPAB-0118-CN-S(P) | Mouse Anti-FOLR1 Recombinant Antibody; scFv Fragment (HPAB-0118-CN-S(P)) | ELISA, FC | Mouse scFv |
| HPAB-0119-CN-S(P) | Mouse Anti-FOLR1 Recombinant Antibody; scFv Fragment (HPAB-0119-CN-S(P)) | ELISA, FC, IHC, WB | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0117-CN-F(E) | Mouse Anti-FOLR1 Recombinant Antibody; Fab Fragment (HPAB-0117-CN-F(E)) | ELISA, FC | Mouse Fab |
| HPAB-0118-CN-F(E) | Mouse Anti-FOLR1 Recombinant Antibody; Fab Fragment (HPAB-0118-CN-F(E)) | ELISA, FC | Mouse Fab |
| HPAB-0119-CN-F(E) | Mouse Anti-FOLR1 Recombinant Antibody; Fab Fragment (HPAB-0119-CN-F(E)) | ELISA, FC, IHC, WB | Mouse Fab |
| HPAB-0120-CN-F(E) | Mouse Anti-FOLR1 Recombinant Antibody; Fab Fragment (HPAB-0120-CN-F(E)) | ELISA, FC, IHC, WB | Mouse Fab |
| HPAB-0080-FY-F(E) | Human Anti-FOLR1 Recombinant Antibody; Fab Fragment (HPAB-0080-FY-F(E)) | FC | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-113 | Afuco™ Anti-FOLR1 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-113) | FC, IP, ELISA, Neut, FuncS, IF | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-CN0049 | APC-A*02:01/Human FBP (EIWTHSYKV) MHC Tetramer | FCM | |
| MHC-CN0050 | PE-A*02:01/Human FBP (EIWTHSYKV) MHC Tetramer | FCM | |
| MHC-CN0685 | PE-A*02:01/Human FOLR1 (EIWTHSYKV) MHC Tetramer | FCM, IHC | |
| MHC-CN0686 | APC-A*02:01/Human FOLR1 (EIWTHSYKV) MHC Tetramer | FCM, IHC | |
| MHC-CN0687 | FITC-A*02:01/Human FOLR1 (EIWTHSYKV) MHC Tetramer | FCM, IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-FY70 | Human Anti-FOLR1 (clone Farletuzumab) scFv-Fc Chimera | ELISA, Inhib | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC262 | Recombinant Anti-FOLR1 Vesicular Antibody, EV Displayed (VS-0425-YC262) | ELISA, FC, Neut, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY2606 | Anti-FOLR1 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-YC13 | Recombinant Anti-FOLR1 Biparatopic Antibody, Asymmetric scFv-Fab | ELISA | Asymmetric scFv-Fab |
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