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    Anti-FOLR1 (Mirvetuximab)-sulfo-SPDB-DM4 ADC (IMGN853)

    CAT#: ADC-L018

    This ADC product is composed of an anti-FOLR1 antibody (Mirvetuximab) conjuagated via a sulfo-SPDB linker to DM4 (Mirvetuximab-sulfo-SPDB-DM4). It has demonstrated a response in ovarian cancer, solid tumor treatment by a MOA (Mechanism of Action) of Depolymerize Microtubules.

    Gene Expression
    ❮
    Figure 1 IF staining of human cell line HeLa Figure 2 RNA cell line category: Group enriched (HeLa, RPTEC TERT1)
    ❯

    Specifications

    • Antibody Overview
    • Murine/human chimeric FOLR1-specific monoclonal IgG1k antibody mirvetuximab
    • Clone
    • Mirvetuximab
    • Antibody Conjugation
    • Chimeric murine/human
    • Linker
    • sulfo-SPDB (sulfosuccinimidyl N-succinimidyl-4-(2-pyridyldithio)butyrate)
    • Linker Class/Description
    • Class: Chemically cleavable linkers-Disulfide Linkers
      Description: Disulfide Linkers are extensively exploited as a chemically labile linkage. Since the release of disulfide-linked drugs requires a cytoplasmic thiol cofactor, such as glutathione (GSH). Disulfides maintain stable at physiological pH and only when ADCs are internalized inside cells, the cytosol provides reducing environment including intracellular enzyme protein disulfide isomerase, or similar enzymes, drugs can be released.
    • Drug
    • DM4 (N2'-Deacetyl-N2'-(4-mercapto-4- methyl-1-oxopentyl)maytansine)
    • Drug Class/Description
    • Class: Maytansinoid
      Description: Maytansinoids are a group of cytotoxins structurally similar to rifamycin, geldanamycin, and ansatrienin. The eponymous natural cytotoxic agent maytansine is a 19-member lactam (ansa
      macrolide) structure originally isolated from the Ethiopian shrub Maytenus ovatus. Maytansinoids can bind to tubulin at or near the vinblastine-binding site, which interfere the formation of microtubules and depolymerize already formed microtubules, inducing mitotic arrest in the intoxicated cells.

    Target

    • Introduction
    • The protein encoded by this gene is a member of the folate receptor family. Members of this gene family bind folic acid and its reduced derivatives, and transport 5-methyltetrahydrofolate into cells. This gene product is a secreted protein that either anchors to membranes via a glycosyl-phosphatidylinositol linkage or exists in a soluble form. Mutations in this gene have been associated with neurodegeneration due to cerebral folate transport deficiency. Due to the presence of two promoters, multiple transcription start sites, and alternative splicing, multiple transcript variants encoding the same protein have been found for this gene.
    • Alternative Names
    • FBP; FOLR
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    Datasheet

    Datasheet - ADC-L018.pdf

    MSDS

    MSDS - ADC-L018.pdf

    COA

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