Recombinant Anti-FOLR1 Vesicular Antibody, EV Displayed (VS-0425-YC262)

Name: Recombinant Anti-FOLR1 Vesicular Antibody, EV Displayed (VS-0425-YC262)
SKU: VS-0425-YC262
Rating: 5 (1 reviews)

CAT#: VS-0425-YC262

The Recombinant Anti-FOLR1 Vesicular Antibody, EV Displayed (VS-0425-YC262) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to FOLR1-expressed cells or tissues. The FOLR1 is a folate receptor, influencing folate transport. Mutations are associated with neurodegeneration due to transport deficiency.

Gene Expression

Subcellular Location Figure 1 IF staining of human cell line HeLa

Immunofluorescent staining of human cell line HeLa shows localization to nuclear membrane.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/77030/1659_B3_2_selected.jpg

RNA Expression Figure 2 RNA cell line category: Group enriched (HeLa, RPTEC TERT1)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000110195-FOLR1

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Recombinant Antibody

Application
ELISA, FC, Neut, Cell-uptake

Product Type
Ab-Fc-EVs

Antibody Quantification (Ab/EV)
~100 Ab/EV

Target
FOLR1

Host Animal
Human

Antibody Isotype
IgG

Species Reactivity
Human

Expression Cell
Mammalian cell

Engineered EVs

EV-sorting domain
CD63

Fc-binding domain
z domain

EV Size
30~150 nm

Producing Cell
HEK293F

Isolation Method
Gradient centrifugation

Purification
qEV size exclusion chromatography

Binding Affinity
Kd = 0.85 µg/mL

Concentration
1 x 10¹⁰

Size
1 mL

Buffer
PBS

Storage
Store at -80°C for 12 months

Target

Full Name
Folate receptor alpha

Biological Process
Transport

Molecular Function
Receptor

Introduction
The protein encoded by this gene is a member of the folate receptor family. Members of this gene family bind folic acid and its reduced derivatives, and transport 5-methyltetrahydrofolate into cells. This gene product is a secreted protein that either anchors to membranes via a glycosyl-phosphatidylinositol linkage or exists in a soluble form. Mutations in this gene have been associated with neurodegeneration due to cerebral folate transport deficiency. Due to the presence of two promoters, multiple transcription start sites, and alternative splicing, multiple transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Oct 2009]

Alternative Names
FOLR, FRalpha

Gene ID
2348

UniProt ID
P15328

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Datasheet

Datasheet - VS-0425-YC262.pdf

MSDS

MSDS - VS-0425-YC262.pdf

COA

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