Human Anti-FOLR1 (clone Farletuzumab) scFv-Fc Chimera (CAT#: VS-0325-FY70)
Anti-FOLR1 scFv-Fc is a recombinant antibody fragment that targets folate receptor 1 (FOLR1). It is made up of a single-chain variable fragment (scFv) and an Fc region. Anti-FOLR1 scFv-Fc is used in research and development of chimeric antigen receptor (CAR) T cells to treat cancer.
Specific Inquiry
Custom Production
We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.
We require custom production
Subcellular Location
RNA Expression
Figure 1 IF staining of human cell line HeLa
(Immunofluorescent staining of human cell line HeLa shows localization to nuclear membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/77030/1659_B3_2_selected.jpg
(Immunofluorescent staining of human cell line HeLa shows localization to nuclear membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/77030/1659_B3_2_selected.jpg
Figure 2 RNA cell line category: Group enriched (HeLa, RPTEC TERT1)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000110195-FOLR1
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000110195-FOLR1
Figure 2 RNA cell line category: Group enriched (HeLa, RPTEC TERT1)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000110195-FOLR1
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000110195-FOLR1
Specifications
- Immunogen
- Human FOLR1
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- Human FOLR1
- Species Reactivity
- Human
- Clone
- Farletuzumab
- Applications
- ELISA, Inhibition
- Related Disease
- Cancer
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- ELISA: 1:5000-1:10000
Target
- Alternative Names
- Folate Receptor 1; Ovarian Tumor-Associated Antigen MOv18; Adult Folate-Binding Protein; Folate Receptor 1 (Adult); Folate Receptor, Adult; Folate Receptor Alpha
- Gene ID
- 2348
- UniProt ID
- P15328
- Long Name
- Folate Receptor 1
- Cellular Localization
- Cell membrane; Cytoplasmic vesicle; Endosome
- Post Translation Modifications
- The secreted form is derived from the membrane-bound form either by cleavage of the GPI anchor, or/and by proteolysis catalyzed by a metalloprotease.
Glycosylation at Asn69, Asn161, and Asn201
Modification sites at PhosphoSitePlus
Glycosylation from GlyConnect FOLR1_HUMAN (1248)
Glycosylation from GlyGen 4 sites, 23 N-linked glycans (3 sites), 1 O-linked glycan (1 site)
- Protein Refseq
- NP_000793.1; NP_057936.1
- Function
- Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells (PubMed:23851396, 23934049, 2527252, 8033114, 8567728, 19074442).
Has high affinity for folate and folic acid analogs at neutral pH (PubMed:23851396, 23934049, 2527252, 8033114, 8567728).
Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release (PubMed:8567728).
Required for normal embryonic development and normal cell proliferation (By similarity).
Recommended Products
Isotype Control
Secondary Antibody
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "FOLR1"
Select a product category from the dropdown menu below to view related products.
Please select product type
IgG Antibody Products
Intrabody Products
Humanized Antibody Products
Human Antibody Products
Mouse Antibody Products
Chimeric Antibody Products
Fc Glycosylation Antibody Products
Low- or Non-fucosylated Oligosaccharide Antibody Products
Rabbit Monoclonal Antibody Products
ScFv Antibody Products
Fab Antibody Products
ADCC Enhanced Antibody Products
MHC Tetramer Products for Cancer
Extracellular Vesicle (EV) Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1297z | Mouse Anti-FOLR1 Recombinant Antibody (clone 24A8) | WB, ELISA, FC, ICC, IF, IHC | Mouse IgG2a |
| HPAB-0080-FY | Human Anti-FOLR1 Recombinant Antibody (HPAB-0080-FY) | FC | Human IgG |
| HPAB-0312-WJ | Mouse Anti-FOLR1 Recombinant Antibody (HPAB-0312-WJ) | ELISA, IHC, FC | Mouse IgG2a |
| HPAB-M0094-YC | Human Anti-FOLR1 Recombinant Antibody (HPAB-M0094-YC) | FuncS | Humanized IgG |
| VS3-CJ671 | Rabbit Anti-FOLR1 Recombinant Antibody (VS3-CJ671) | WB, IHC, FC | Rabbit IgG |
Customer Reviews and Q&As
There are currently no Customer reviews or questions for VS-0325-FY70. Click the button above to contact us or submit your feedback about this product.
Popular products with customers
Application: IF, IP, Neut, FuncS, ELISA, FC, WB
Application: WB, IF, IP, Neut, FuncS, ELISA, FC
Application: ELISA, IP, FC, FuncS, Neut, IF, ICC
Application: IP, IF, FuncS, FC, Neut, ELISA, ICC
Application: ELISA, FC, IP, FuncS, IF, Neut, ICC
Application: IP, IF, FuncS, FC, Neut, ELISA, ICC
Application: ELISA, FC, IF, WB
-1.jpg)
Application: FC
-1.jpg)
Application: ELISA, WB
Application: ELISA, Neut
For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
