Human Anti-FOLR1 (clone Farletuzumab) scFv-Fc Chimera (CAT#: VS-0325-FY70)
Anti-FOLR1 scFv-Fc is a recombinant antibody fragment that targets folate receptor 1 (FOLR1). It is made up of a single-chain variable fragment (scFv) and an Fc region. Anti-FOLR1 scFv-Fc is used in research and development of chimeric antigen receptor (CAR) T cells to treat cancer.
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Subcellular Location
RNA Expression
Figure 1 IF staining of human cell line HeLa
(Immunofluorescent staining of human cell line HeLa shows localization to nuclear membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/77030/1659_B3_2_selected.jpg
(Immunofluorescent staining of human cell line HeLa shows localization to nuclear membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/77030/1659_B3_2_selected.jpg
Figure 2 RNA cell line category: Group enriched (HeLa, RPTEC TERT1)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000110195-FOLR1
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000110195-FOLR1
Figure 2 RNA cell line category: Group enriched (HeLa, RPTEC TERT1)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000110195-FOLR1
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000110195-FOLR1
Specifications
- Immunogen
- Human FOLR1
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- Human FOLR1
- Species Reactivity
- Human
- Clone
- Farletuzumab
- Applications
- ELISA, Inhibition
- Related Disease
- Cancer
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- ELISA: 1:5000-1:10000
Target
- Alternative Names
- Folate Receptor 1; Ovarian Tumor-Associated Antigen MOv18; Adult Folate-Binding Protein; Folate Receptor 1 (Adult); Folate Receptor, Adult; Folate Receptor Alpha
- Gene ID
- 2348
- UniProt ID
- P15328
- Long Name
- Folate Receptor 1
- Cellular Localization
- Cell membrane; Cytoplasmic vesicle; Endosome
- Post Translation Modifications
- The secreted form is derived from the membrane-bound form either by cleavage of the GPI anchor, or/and by proteolysis catalyzed by a metalloprotease.
Glycosylation at Asn69, Asn161, and Asn201
Modification sites at PhosphoSitePlus
Glycosylation from GlyConnect FOLR1_HUMAN (1248)
Glycosylation from GlyGen 4 sites, 23 N-linked glycans (3 sites), 1 O-linked glycan (1 site)
- Protein Refseq
- NP_000793.1; NP_057936.1
- Function
- Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells (PubMed:23851396, 23934049, 2527252, 8033114, 8567728, 19074442).
Has high affinity for folate and folic acid analogs at neutral pH (PubMed:23851396, 23934049, 2527252, 8033114, 8567728).
Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release (PubMed:8567728).
Required for normal embryonic development and normal cell proliferation (By similarity).
Recommended Products
Isotype Control
Secondary Antibody
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Extracellular Vesicle (EV) Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1297z | Mouse Anti-FOLR1 Recombinant Antibody (clone 24A8) | WB, ELISA, FC, ICC, IF, IHC | Mouse IgG2a |
| HPAB-0080-FY | Human Anti-FOLR1 Recombinant Antibody (HPAB-0080-FY) | FC | Human IgG |
| HPAB-0312-WJ | Mouse Anti-FOLR1 Recombinant Antibody (HPAB-0312-WJ) | ELISA, IHC, FC | Mouse IgG2a |
| HPAB-M0094-YC | Human Anti-FOLR1 Recombinant Antibody (HPAB-M0094-YC) | FuncS | Humanized IgG |
| VS3-CJ671 | Rabbit Anti-FOLR1 Recombinant Antibody (VS3-CJ671) | WB, IHC, FC | Rabbit IgG |
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