Afuco™ Anti-FOLR1 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-113) (CAT#: AFC-TAB-113)
This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant monoclonal antibody to folate receptor 1. It is a monoclonal antibody which is being investigated for the treatment of ovarian cancer, It is targeted at FR-alpha which is overexpressed in some cancers such as ovarian cancer.
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Subcellular Location
RNA Expression
Figure 1 IF staining of human cell line HeLa
(Immunofluorescent staining of human cell line HeLa shows localization to nuclear membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/77030/1659_B3_2_selected.jpg
(Immunofluorescent staining of human cell line HeLa shows localization to nuclear membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/77030/1659_B3_2_selected.jpg
Figure 2 RNA cell line category: Group enriched (HeLa, RPTEC TERT1)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000110195-FOLR1
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000110195-FOLR1
Figure 2 RNA cell line category: Group enriched (HeLa, RPTEC TERT1)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000110195-FOLR1
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000110195-FOLR1
Specifications
- Immunogen
- Gestational choriocarcinoma cell line, Lu-75.
- Host Species
- Human
- Derivation
- Humanized (from mouse)
- Type
- ADCC enhanced antibody
- Species Reactivity
- Human
- Applications
- FC, IP, ELISA, Neut, FuncS, IF
- Conjugate
- Unconjugated
- Generic Name
- Farletuzumab
- Related Disease
- Ovarian cancers
Product Property
- Purity
- >95% by SDS-PAGE
- Storage
- Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- FOLR1; folate receptor 1 (adult); FOLR; folate receptor alpha; FR-alpha; KB cells FBP; folate binding protein; folate receptor, adult; adult folate-binding protein; ovarian tumor-associated antigen MOv18; FBP;
- Gene ID
- 2348
- UniProt ID
- P15328
Related Resources
Please refer to Farletuzumab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Farletuzumab.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "Farletuzumab"
DrugMonitor™ Anti-Farletuzumab Antibody (VS-1224-YC466)Farletuzumab (MORAb-003) is a fully humanized monoclonal antibody targeting the folate receptor alpha, developed for epithelial ovarian cancer treatment. The DrugMonitor™ Anti-Farletuzumab Antibody (VS-1224-YC466) is an anti-drug antibody (ADA) against Farletuzumab. This drug-based antibody is raised in mice immunized with the Farletuzumab. The anti-Farletuzumab antibody may be used in ELISA, pharmacokinetics (PK), and pharmacodynamics (PD) analyses, or serves as a reference standard in ADA assays. It also is an excellent tool for therapeutic drug monitoring, allowing to evaluate the drug efficacy and determine the drug concentration of the Farletuzumab in samples.
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| IAB-B029(A) | Recombinant Anti-human FOLR1 Intrabody [(D-Arg)9] | PCA, Neut, FuncS | scFv-(D-Arg)9 |
| IAB-B029(G) | Recombinant Anti-human FOLR1 Intrabody [+36 GFP] | WB, Neut, FuncS | scFv-(+36GFP) |
| IAB-B029(T) | Recombinant Anti-human FOLR1 Intrabody [Tat] | WB, ICC, Neut, FuncS | scFv-Tat |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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