Mouse Anti-GCGR Recombinant Antibody (clone 6.23V3)
CAT#: HPAB-0023-LS
The antibody provides an anti-GCGR antibody capable of blocking GCGR binding to glucagon.
Published Data
Gene Expression
Figure 1 A single dose of H6.23.v3 improves glucose tolerance in diabetic ZDF.
Figure 2 A single dose of H6.23.v3 provides acute reduction in blood glucose in Zucker Diabetic Fatty (ZDF) rats.
Figure 3 Blood glucose in db/db mice 24 hours after a single dose of H6.23v2.
The bar graphs show fasting blood glucose (mg/dL) versus H6.23v2 mAb (mg/kg) at various concentrations (mg/kg).
FuncS
Figure 4 The inhibition of glucagon-induced G6Pase gene expression in primary human heptocytes.
FuncS
Figure 5 Inhibition of ¹²⁵I glucagon binding to primary human hepatocytes by H6.23 series competitive antibodies.
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Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to the Golgi apparatus.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/71228/1338_A11_7_selected.jpg
RNA Expression
Figure 2 RNA cell line category: Cell line enhanced (HeLa, MCF7, SK-BR-3, U-87 MG)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000215644-GCGR
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Specifications
- Immunogen
- GCGR
- Host Species
- Mouse
- Derivation
- Phage display library
- Type
- Mouse IgG1 κ
- Specificity
- Human GCGR
- Species Reactivity
- Human
- Clone
- 6.23V3
- Applications
- WB, FC, FuncS
- Related Disease
- Diabetes mellitus
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- This antibody has been tested for use in Functional Assay.
Target
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1786z | Mouse Anti-GCGR Recombinant Antibody (clone 40C5) | WB, ELISA | Mouse IgG1, κ |
| PABW-048 | Mouse Anti-GCGR Recombinant Antibody (clone HGR-2 F6) | Block | Mouse IgG |
| HPAB-0138-FY | Human Anti-GCGR Recombinant Antibody (HPAB-0138-FY) | Block | Human IgG4, κ |
| HPAB-0105LY | Human Anti-GCGR Recombinant Antibody (HPAB-0105LY) | ELISA | Human IgG |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBL-477 | Recombinant Human Anti-GCGR Antibody Fab Fragment (PFBL-477) | WB, ELISA, FuncS | Fab |
| HPAB-0817-FY-S(P) | Human Anti-GCGR Recombinant Antibody; scFv Fragment (HPAB-0817-FY-S(P)) | ELISA, RIA, FC | Human scFv |
| HPAB-3385LY-F(E) | Human Anti-GCGR Recombinant Antibody (clone CBL150); Fab Fragment | ELISA | Human Fab |
| HPAB-3386LY-F(E) | Human Anti-GCGR Recombinant Antibody (clone CBL151); Fab Fragment | ELISA | Human Fab |
| HPAB-3387LY-F(E) | Human Anti-GCGR Recombinant Antibody (clone CBL152); Fab Fragment | ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBW-048 | Mouse Anti-GCGR Recombinant Antibody (clone HGR-2 F6); scFv Fragment | Block | Mouse scFv |
| HPAB-0817-FY-F(E) | Human Anti-GCGR Recombinant Antibody; Fab Fragment (HPAB-0817-FY-F(E)) | ELISA, RIA, FC | Human Fab |
| HPAB-0818-FY-F(E) | Human Anti-GCGR Recombinant Antibody; Fab Fragment (HPAB-0818-FY-F(E)) | ELISA, RIA, FC | Human Fab |
| HPAB-0819-FY-F(E) | Human Anti-GCGR Recombinant Antibody; Fab Fragment (HPAB-0819-FY-F(E)) | ELISA, RIA, FC | Human Fab |
| HPAB-0820-FY-F(E) | Human Anti-GCGR Recombinant Antibody; Fab Fragment (HPAB-0820-FY-F(E)) | ELISA, RIA, FC | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-063CQ | Anti-Human GCGR Recombinant Antibody (mAb5) | ELISA, FC | |
| TAB-064CQ | Anti-Human GCGR Recombinant Antibody (3C7) | ELISA, FC, WB | |
| TAB-067CQ | Mouse Anti-GCGR Recombinant Antibody (TAB-067CQ) | ELISA, FC | Mouse IgG |
| TAB-063CQ-F(E) | Anti-Human GCGR Recombinant Antibody Fab Fragment (mAb5) | ELISA, FC | |
| PABX-067-F (E) | Recombinant Mouse Anti-GR-2 Antibody Fab Fragment (F6) | WB, Neut, FuncS | Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-066CQ | Anti-Human GCGR Recombinant Antibody (3C7v11) | ELISA, FC, WB | Humanized antibody |
| TAB-066CQ-S(P) | Anti-Human GCGR Recombinant Antibody scFv Fragment (3C7v11) | ELISA, FC, WB | Humanized antibody |
| TAB-066CQ-F(E) | Anti-Human GCGR Recombinant Antibody Fab Fragment (3C7v11) | ELISA, FC, WB | Humanized antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-065CQ-S(P) | Anti-Human GCGR Recombinant Antibody scFv Fragment (H6.23v3) | ELISA, FC, WB | Human antibody |
| TAB-068CQ-S(P) | Human Anti-GCGR Recombinant Antibody; scFv Fragment (TAB-068CQ-S(P)) | ELISA, FC | Human scFv |
| TAB-065CQ-F(E) | Anti-Human GCGR Recombinant Antibody Fab Fragment (H6.23v3) | ELISA, FC, WB | Human antibody |
| TAB-068CQ-F(E) | Human Anti-GCGR Recombinant Antibody; Fab Fragment (TAB-068CQ-F(E)) | ELISA, FC | Human Fab |
| TAB-069CQ-F(E) | Human Anti-GCGR Recombinant Antibody; Fab Fragment (TAB-069CQ-F(E)) | ELISA, FC | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-113LC | Recombinant Anti-Human GCGR Antibody (Fc glycosylation) | ELISA | Chimeric antibody (mouse/human) |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-FY112 | Human Anti-GCGR scFv-Fc Chimera (VS-0425-FY112) | Inhib | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC385 | Recombinant Anti-GCGR Vesicular Antibody, EV Displayed (VS-0425-YC385) | ELISA, FC, Neut, Cell-uptake |
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