Mouse Anti-GCGR Recombinant Antibody (clone 6.23V3) (CAT#: HPAB-0023-LS)
The antibody provides an anti-GCGR antibody capable of blocking GCGR binding to glucagon.
Specific Inquiry
Figure 1 A single dose of H6.23.v3 improves glucose tolerance in diabetic ZDF.
Figure 2 A single dose of H6.23.v3 provides acute reduction in blood glucose in Zucker Diabetic Fatty (ZDF) rats.
Figure 3 Blood glucose in db/db mice 24 hours after a single dose of H6.23v2.
The bar graphs show fasting blood glucose (mg/dL) versus H6.23v2 mAb (mg/kg) at various concentrations (mg/kg).
FuncS
Figure 4 The inhibition of glucagon-induced G6Pase gene expression in primary human heptocytes.
FuncS
Figure 5 Inhibition of ¹²⁵I glucagon binding to primary human hepatocytes by H6.23 series competitive antibodies.
Specifications
- Immunogen
- GCGR
- Host Species
- Mouse
- Derivation
- Phage display library
- Type
- Mouse IgG1 κ
- Specificity
- Human GCGR
- Species Reactivity
- Human
- Clone
- 6.23V3
- Applications
- WB, FC, FuncS
- Related Disease
- Diabetes mellitus
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- This antibody has been tested for use in Functional Assay.
Target
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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ScFv Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBL-099 | Mouse Anti-GCGR Recombinant Antibody (clone mAb7); Fab Fragment | ELISA, WB, FuncS | Mouse Fab |
| HPAB-0023-LS-S(P) | Mouse Anti-GCGR Recombinant Antibody (clone 6.23V3); scFv Fragment | WB, FC | Mouse scFv |
| HPAB-3385LY-F(E) | Human Anti-GCGR Recombinant Antibody (clone CBL150); Fab Fragment | ELISA | Human Fab |
| HPAB-3386LY-F(E) | Human Anti-GCGR Recombinant Antibody (clone CBL151); Fab Fragment | ELISA | Human Fab |
| HPAB-3387LY-F(E) | Human Anti-GCGR Recombinant Antibody (clone CBL152); Fab Fragment | ELISA | Human Fab |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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