Anti-Human IL17A Recombinant Antibody (TAB-069) (CAT#: TAB-069)
Recombinant monoclonal antibody to IL17A. It is a human monoclonal antibody designed for the treatments of uveitis, rheumatoid arthritis, and psoriasis. It targets member A from the cytokine family of interleukin 17.
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ELISA
Figure 1 Anti-Human IL17A Antibody (TAB-069) in ELISA
ELISA analysis of TAB-069 was performed by coating with Human IL17A Protein (No Tag). Then blocked with BSA and incubated with TAB-069. The HRP-conjugated goat anti-human IgG as a secondary antibody (1: 5000). Detection was performed using TMB substrate and stopped with sulfuric acid. The absorbances were read on a spectrophotometer at 450 nm.
WB
Figure 2 Anti-Human IL17A Antibody (TAB-069) in WB
Western blot analysis of TAB-069 was performed with Human IL17A Protein (No Tag) in reduced condition Lane 1, Lane 2 and Lane 3 (0.1 μg, 0.3 μg and 0.6 μg respectively) onto a 12% Tris-HCl polyacrylamide gel. Proteins were transferred to a CN membrane and blocked with 5% skim milk for at least one hour. Membranes were probed with TAB-069 (2 μg/mL) and HRP-conjugated goat anti-human IgG as a secondary antibody (1: 6000). Chemiluminescent detection was performed.
DB
Figure 3 Anti-Human IL17A Antibody (TAB-069) in DB
Dot Blot analysis of TAB-069 was performed by coating with Human IL17A Protein (No Tag).
TAB-069 incubation concentration: 2 μg/mL.
HRP goat anti-human IgG as a secondary antibody (1: 6000)
NC: Negative control PC: Positive control
Specifications
- Immunogen
- HuIL-17 coupled 10 KLH mixed 1:1 with huIL-17 in Gerbu adjuvant.
- Host Species
- Human
- Derivation
- Human
- Type
- IgG1 - kappa
- Specificity
- Tested positive against native human antigen.
- Species Reactivity
- Human
- Applications
- IF, IHC, ELISA, FC
- MW
- 147.94 kDa
- Related Disease
- Psoriatic arthritis (PSA)
Product Property
- Purity
- >95.0% as determined by Analysis by RP-HPLC & analysis by SDS-PAGE.
- Storage
- At -20°C for one year.
Applications
- Application Notes
- The IL17A antibody has been reported in applications of Immunofluorescence, Immunohistochemistry, Enzyme-linked Immunosorbent Assay, Flow Cytometry. FC: The isotype, IL17RA AlexaFluor 647 and IL17RC AlexaFluor 488 antibodies were used at 4mg/ml and 10mg/ml respectively for FACs analysis.
Target
- Alternative Names
- Secukinumab;Cosentyx;875356-43-7;AIN457;DB09029IL17A;interleukin 17A;CTLA8, IL17, interleukin 17 (cytotoxic T lymphocyte associated serine esterase 8);interleukin-17A;cytotoxic T lymphocyte associated protein 8;IL 17;IL 17A;CTLA-8;cytotoxic T-lymphocyte-a
- Gene ID
- 3605
- UniProt ID
- Q16552
Related Resources
Please refer to Secukinumab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Secukinumab.
Inflammatory Bowel Diseases
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
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ScFv-Fc Chimera Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-H57 | Anti-Human IL17A Recombinant Antibody (Perakizumab) | WB, ELISA, IP, FC, FuncS, Neut, IF | IgG1 - kappa |
| TAB-H08 | Anti-Human IL17A/IL17F Recombinant Antibody (TAB-H08) | ELISA, FC, IP, FuncS, IF, Neut, WB | IgG1 - kappa |
| TAB-048ZJ | Human Anti-IL17A Recombinant Antibody (TAB-048ZJ) | ELISA, Neut | Humanized antibody |
| TAB-048ZJ-S(P) | Human Anti-IL17A Recombinant Antibody; scFv Fragment (TAB-048ZJ-S(P)) | ELISA, Neut | Human scFv |
| TAB-458CQ | Anti-Human IL17A Recombinant Antibody (TAB-458CQ) | ELISA, IHC, FC, IP, IF, Inhib | IgG1, κ |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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