Secukinumab Overview

Introduction of Secukinumab

Secukinumab (Cosentyx) is a fully human IgG1/κ-class monoclonal antibody (mAb) composed of 215 light chain amino acids and 457 heavy chain amino acids. It was discovered and developed by Novartis with the developmental name AIN457, for the treatment of uveitis, rheumatoid arthritis, ankylosing spondylitis, and psoriasis. It is produced in Chinese Hamster Ovary (CHO) cells using recombinant DNA technology.

It binds to and neutralises the proinflammatory cytokine interleukin-17A (IL-17A). In January 2015, the U.S. Food and Drug Administration (FDA) approved secukinumab (trade name Cosentyx) to treat adults with moderate-to-severe plaque psoriasis. It was the first IL17A inhibiting drug ever approved. In January 2016, the FDA approved it to treat adults with ankylosing spondylitis, and psoriatic arthritis and in February 2018 a label update was approved to include the treatment for moderate-to-severe scalp psoriasis. Till now, Cosentyx has gained the approval for marketing in USA, Europe Union, Canada, Japan, and Australia for the treatment of psoriasis, ankylosing spondylitis, and psoriatic arthritis. It is given by subcutaneous injection and is sold in a pre-filled syringe or autoinjector that can be used at home and as a lyophilized powder for use in hospitals and clinics.

Mechanism of Action of Secukinumab

Secukinumab works by targeting IL-17A and inhibiting its interaction with the IL-17 receptor. IL-17A can be produced by a range of different cell types as part of both the adaptive and innate immune responses, including neutrophils, macrophages, mast cells, Group 3 innate lymphoid cells, T helper 17 (Th17) cells and cytotoxic T cells. IL-17A is a naturally occurring cytokine that is involved in normal inflammatory and immune responses. IL-17A plays a key role in the pathogenesis of plaque psoriasis, psoriatic arthritis and ankylosing spondylitis and is up-regulated in lesional skin in contrast to non-lesional skin of plaque psoriasis patients and in synovial tissue of psoriatic arthritis patients. The frequency of IL-17-producing cells was also significantly higher in the subchondral bone marrow of facet joints from patients with ankylosing spondylitis. Secukinumab selectively binds to and neutralizes IL-17A, preventing its interaction with the IL-17 receptors expressed on keratinocytes, fibroblast-like synoviocytes, endothelial cells, chondrocytes and osteoblasts. As a result, secukinumab inhibits the release of proinflammatory cytokines, chemokines and mediators of tissue damage and reduces IL-17A-mediated contributions to autoimmune and inflammatory diseases. Clinically relevant levels of secukinumab reach the skin and reduce local inflammatory markers. As a direct consequence treatment with secukinumab reduces erythema, induration and desquamation present in plaque psoriasis lesions.

Fig.1 Mechanism of action of Secukinumab

Clinical Projects of Secukinumab*

Approved Drugs of Secukinumab**

INN (trade name)	Therapeutic area	Dose	Strength	Route	Company	Marketing start	Market
Cosentyx	Ankylosing Spondylitis, Psoriatic Arthritis, Plaque Psoriasis	Solution	150 mg/mL	Subcutaneous	Novartis Pharms Corp.	January 21, 2015
Cosentyx	Ankylosing Spondylitis, Psoriatic Arthritis, Plaque Psoriasis	Powder for solution	150 mg/mL	Subcutaneous	Novartis Pharms Corp.	January 21, 2015
Cosentyx	Ankylosing Spondylitis, Psoriatic Arthritis, Plaque Psoriasis	Powder for solution	150 mg	Subcutaneous	Novartis Europharm Limited	January 15, 2015
Cosentyx	Ankylosing Spondylitis, Psoriatic Arthritis, Plaque Psoriasis	Powder for solution	150 mg	Subcutaneous	Novartis Pharmaceuticals Canada Inc.	February 27, 2015
Cosentyx	Ankylosing Spondylitis, Psoriatic Arthritis, Plaque Psoriasis	Solution	150 mg/mL	Subcutaneous	Novartis Pharmaceuticals Canada Inc.	April 10, 2015
Cosentyx	Ankylosing Spondylitis, Psoriatic Arthritis, Plaque Psoriasis	Powder for solution	150 mg	Subcutaneous	Novartis Pharmaceuticals Australia Pty Ltd	January 12, 2015
Cosentyx	Plaque Psoriasis	Powder for solution	180 mg	Subcutaneous	Novartis Pharma K.K.	December 21, 2015
Cosentyx	Ankylosing Spondylitis, Psoriatic Arthritis, Plaque Psoriasis	Solution	150 mg/mL	Subcutaneous	Novartis Pharmaceuticals Australia Pty Ltd	January 12, 2015
Cosentyx	Ankylosing Spondylitis, Psoriatic Arthritis	Solution	150 mg/mL	Subcutaneous	Novartis Pharma K.K.	December 26, 2014

What We Provide

Therapeutic Antibody

Secukinumab

We provide high-quality Secukinumab for use in WB, FC, IP, ELISA, Neut, FuncS, IF and most other immunological methods. For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

Resources
* The table was excerpted from the following website
https://clinicaltrials.gov/ct2/results?cond=&term=Secukinumab

** Information presented in the table were collected from the following websites:
http://www.pmda.go.jp/PmdaSearch/iyakuDetail/GeneralList/3999439G1
https://health-products.canada.ca/dpd-bdpp/info.do?lang=en&code=92242
https://health-products.canada.ca/dpd-bdpp/info.do?lang=en&code=92243
https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo= 125504
http://www.ema.europa.eu/ema/index.jsp?curl=pages/medicines/human/medicines/003729/human_med_001832.jsp
http://search.tga.gov.au/s/search.html?collection=tga-artg&profile=record&meta_i=218798
http://search.tga.gov.au/s/search.html?collection=tga-artg&profile=record&meta_i=218800

For research use only. Not intended for any clinical use.