Anti-Human IL1Beta Recombinant Antibody (Canakinumab) (CAT#: TAB-021)

Recombinant monoclonal antibody to Human IL1 beta. Canakinumab (INN, trade name Ilaris, previously ACZ885) is a human monoclonal antibody targeted at interleukin-1 beta. It has no cross-reactivity with other members of the interleukin-1 family, including interleukin-1 alpha.
Canakinumab was for the treatment of rheumatoid arthritis. Canakinumab is as a possible treatment for chronic obstructive pulmonary disease, gout and coronary artery disease.

Host: Human

Isotype: IgG1 - kappa

Applications: Suitable for use in FC, IP, ELISA, Neut, FuncS, IF, IHC and most other immunological methods.


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ELISA

Figure 1 Human IL1 Beta Therapeutic Antibody (TAB-021) in ELISA

ELISA analysis of TAB-021 was performed by coating with Recombinant Human IL1 Beta.

WB

Figure 2 Human IL1 Beta Therapeutic Antibody (TAB-021) in WB

Western blot analysis of TAB-021 was performed with Recombinant Human IL1 Beta.
Lane 1: Non-Reducing Antigen (1ug)
Lane 2: Reducing Antigen (1ug)


Specifications

  • Immunogen
  • Recombinant human ILI beta
  • Host Species
  • Human
  • Derivation
  • Human
  • Type
  • IgG1 - kappa
  • Specificity
  • Tested positive against native human antigen
  • Species Reactivity
  • Human
  • Applications
  • Suitable for use in FC, IP, ELISA, Neut, FuncS, IF, IHC and most other immunological methods.
  • Trade name
  • ilaris
  • CAS
  • 914613-48-2
  • Generic Name
  • Canakinumab
  • ATC Code
  • L04AC08
  • DrugBank
  • DB06168
  • UNII
  • 37CQ2C7X93
  • ChEMBL
  • CHEMBL1201834
  • MW
  • 145.2 kDa
  • Related Disease
  • Rheumatoid arthritis (RA)

Product Property

  • Purity
  • Purity >95% by SDS-PAGE.
  • Storage
  • Store at -20°C. Avoid multiple freeze/thaw cycles.

Target

  • Alternative Names
  • Canakinumab;ilaris;914613-48-2;ACZ885;DB06168Catabolin;H1;Hematopoietin 1;IFN beta inducing factor;IL 1;IL 1 beta;IL 1B;IL-1 beta;IL1 BETA;IL1F2;Interleukin 1 beta;Interleukin 1 beta precursor;Interleukin-1 beta;LAF;OAF;Osteoclast activating factor;OTTHUM

Related Resources

  • Biosimilar Overview
  • Related Diseases
  • Related Signaling Pathways
Please refer to Canakinumab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Canakinumab.

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "Canakinumab"

Afuco™ Anti-IL1B ADCC Recombinant Antibody (Canakinumab), ADCC Enhanced
This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant monoclonal antibody to Human IL1 beta. Canakinumab (INN, trade name Ilaris, previously ACZ885) is a human monoclonal antibody targeted at interleukin-1 beta. It has no cross-reactivity with other members of the interleukin-1 family, including interleukin-1 alpha.
Canakinumab was for the treatment of rheumatoid arthritis. Canakinumab is as a possible treatment for chronic obstructive pulmonary disease, gout and coronary artery disease.

See other products for "IL1B"

Humanized Antibody

CAT Product Name Application Type
TAB-161 Anti-Human IL1 beta Recombinant Antibody (Gevokizumab) ELISA, FC, IP, FuncS, IF, Neut, ICC IgG2 - kappa
TAB-233CT-F(E) Human Anti-IL1B Recombinant Antibody; Fab Fragment (TAB-233CT-F(E)) ELISA Humanized Fab
TAB-236CT-F(E) Anti-Human IL-1β (Interleukin 1 beta) Recombinant Antibody Fab Fragment (huSK48-E26) ELISA, Neut Humanized antibody
TAB-544LC-F(E) Anti-human IL1B Fab Fragment, Humanized ELISA Humanized antibody
TAB-549LC-F(E) Human Anti-IL1B Recombinant Antibody; Fab Fragment (TAB-549LC-F(E)) ELISA, SPR Humanized Fab

Recombinant Antibody

CAT Product Name Application Type
PABL-239 Human Anti-IL1B Recombinant Antibody (clone YC129) WB, IHC, FuncS Human IgG
HPAB-0030-YC Human Anti-IL1B Recombinant Antibody (clone B1) Inhib, WB, ELISA Humanized IgG1, κ
HPAB-0031-YC Human Anti-IL1B Recombinant Antibody (clone ABT2-76) ELISA, Neut Human IgG
HPAB-0032-YC Human Anti-IL1B Recombinant Antibody (clone AAL160) Neut, Block Human IgG1, κ
HPAB-1748-FY Human Anti-IL1B Recombinant Antibody (HPAB-1748-FY) Stim, Neut, Inhib Human IgG

Mouse Antibody

CAT Product Name Application Type
TAB-230CT Mouse Anti-IL1B Recombinant Antibody (TAB-230CT) ELISA Mouse IgG
TAB-231CT Anti-Human IL-1β (Interleukin 1 beta) Recombinant Antibody (47F11) Inhibition
TAB-234CT Rabbit Anti-IL1B Recombinant Antibody (TAB-234CT) FC, ELISA, Neut Rabbit IgG
TAB-548LC Rabbit Anti-IL1B Recombinant Antibody (TAB-548LC) ELISA, SPR, Inhib Rabbit IgG
TAB-542LC-S(P) Anti-human IL1B scFv Fragment (SK48-E26) ELISA

Chimeric Antibody

CAT Product Name Application Type
TAB-232CT-S(P) Anti-Human IL-1β (Interleukin 1 beta) Recombinant Antibody scFv Fragment (ch47F11) Inhibition Chimeric antibody (mouse/human)
TAB-237CT-S(P) Anti-Human IL-1β (Interleukin 1 beta) Recombinant Antibody scFv Fragment (chSK48-E26) ELISA, Neut Chimeric antibody (mouse/human)
TAB-237CT-F(E) Anti-Human IL-1β (Interleukin 1 beta) Recombinant Antibody Fab Fragment (chSK48-E26) ELISA, Neut Chimeric antibody (mouse/human)
TAB-543LC Anti-human IL1B Recombinant Antibody, Chimeric (TAB-543LC) ELISA Chimeric antibody (mouse/human)
TAB-543LC-F(E) Anti-human IL1B Fab Fragment, Chimeric ELISA Chimeric antibody (mouse/human)

Human Antibody

CAT Product Name Application Type
TAB-550LC Anti-human IL1B Recombinant Antibody (9.5.2) (TAB-550LC) ELISA, Inhib, FuncS Human antibody
TAB-551LC Anti-human IL1B Recombinant Antibody (5.5.1) (TAB-551LC) ELISA, Inhib Human antibody
TAB-552LC Anti-human IL1B Recombinant Antibody (8.18.1) (TAB-552LC) ELISA, Inhib Human antibody
TAB-545LC-S(P) Human Anti-IL1B Recombinant Antibody; scFv Fragment (TAB-545LC-S(P)) ELISA, FC Human scFv
TAB-546LC-S(P) Human Anti-IL1B Recombinant Antibody; scFv Fragment (TAB-546LC-S(P)) ELISA, FC Human scFv

Chicken IgY Antibody

CAT Product Name Application Type
BRD-0282MZ Chicken Anti-Interleukin-1β Polyclonal IgY WB, Indirect ELISA Chicken antibody

Neutralizing Antibody

CAT Product Name Application Type
NEUT-1271CQ Recombinant Mouse Anti-IL1B Antibody (CBL665) Neut IgG1
NEUT-1272CQ Mouse Anti-IL1B Recombinant Antibody (clone 4M27) IHC, Neut, WB Mouse IgG2
NEUT-1273CQ Mouse Anti-IL1B Recombinant Antibody (clone 8516.311) ELISA, WB, Neut Mouse IgG1
NEUT-1275CQ Mouse Anti-IL1B Recombinant Antibody (clone 2805R) ELISA, Neut, WB, ICC Mouse IgG1
NEUT-1276CQ Mouse Anti-IL1B Recombinant Antibody (clone CBL697) Neut, ELISA Mouse IgG

Blocking Antibody

CAT Product Name Application Type
NEUT-1274CQ Mouse Anti-IL1B Recombinant Antibody (clone B-A15) Block, FC Mouse IgG1
NEUT-1285CQ Mouse Anti-IL1B Recombinant Antibody (clone H1b-27) ELISA, ELISPOT, Block Mouse IgG2b, κ

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-1798 Rabbit Anti-IL1B Recombinant Antibody (clone DS1798AB) WB Rabbit IgG
MOR-4237 Rabbit Anti-IL1B Recombinant Antibody (clone SI316DS) ELISA Rabbit IgG
MOR-4238 Rabbit Anti-IL1B Recombinant Antibody (clone SI317DS) ELISA Rabbit IgG
MOR-4239 Rabbit Anti-IL1B Recombinant Antibody (clone SI318DS) ELISA Rabbit IgG
MOR-4605 Rabbit Anti-IL1B Recombinant Antibody (clone TH118DS) WB Rabbit IgG

Fab Fragment Antibody

CAT Product Name Application Type
HPAB-0330-FY-F(E) Mouse Anti-IL1B Recombinant Antibody (clone 048-Ab-1); Fab Fragment In vivo, ELISA Mouse Fab
HPAB-0331-FY-F(E) Mouse Anti-IL1B Recombinant Antibody (clone 048-Ab-3); Fab Fragment In vivo, ELISA Mouse Fab
HPAB-0332-FY-F(E) Mouse Anti-IL1B Recombinant Antibody (clone 048-Ab-6); Fab Fragment In vivo, ELISA Mouse Fab
HPAB-0333-FY-F(E) Human Anti-IL1B Recombinant Antibody (clone pAb); Fab Fragment ELISA Human Fab
HPAB-0729-FY-S(P) Mouse Anti-IL1B Recombinant Antibody; scFv Fragment (HPAB-0729-FY-S(P)) ELISA, Neut Mouse scFv

ADCC Enhanced Antibody

CAT Product Name Application Type
AFC-TAB-021 Afuco™ Anti-IL1B ADCC Recombinant Antibody (Canakinumab), ADCC Enhanced ELISA, IP, FC, FuncS, Neut ADCC enhanced antibody
AFC-TAB-161 Afuco™ Anti-IL1B ADCC Recombinant Antibody (Gevokizumab), ADCC Enhanced ELISA, FC, IP, FuncS, IF, Neut ADCC enhanced antibody

scFv Fragment Antibody

CAT Product Name Application Type
HPAB-1228-FY-F(E) Human Anti-IL1B Recombinant Antibody; Fab Fragment (HPAB-1228-FY-F(E)) ELISA Humanized Fab
HPAB-0916-WJ-S(P) Human Anti-IL1B Recombinant Antibody; scFv Fragment (HPAB-0916-WJ-S(P)) ELISA Humanized scFv
HPAB-0917-WJ-S(P) Human Anti-IL1B Recombinant Antibody; scFv Fragment (HPAB-0917-WJ-S(P)) WB, ELISA, Block Humanized scFv
HPAB-0918-WJ-S(P) Human Anti-IL1B Recombinant Antibody; scFv Fragment (HPAB-0918-WJ-S(P)) ELISA Humanized scFv
HPAB-1266WJ-S(P) Mouse Anti-IL1B Recombinant Antibody; scFv Fragment (HPAB-1266WJ-S(P)) ELISA, WB Mouse scFv

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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