Anti-Human VEGF Receptor 2 Recombinant Antibody (Ramucirumab) (CAT#: TAB-079)

Recombinant monoclonal antibody to VEGF Receptor 2. Ramucirumab (IMC-1121B) is a fully human monoclonal antibody (IgG1) for the treatment of solid tumors. It is directed against the vascular endothelial growth factor receptor 2 (VEGFR2). By binding to VEGFR2 it works as a receptor antagonist blocking the binding of vascular endothelial growth factor (VEGF) to VEGFR2. VEGFR2 is known to mediate the majority of the downstream effects of VEGF in angiogenesis.

Host: Human

Isotype: IgG1 - kappa

Applications: FC, IHC


Specific Inquiry
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  • Published Data
  • Gene Expression
  • Datasheet
  • MSDS
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FC

Figure 1 Impact of anti-VEGFR2 blockade on PBMCs in vitro.

VEGFR2 expression in several T-cell subsets.

Tada, Y., Togashi, Y., Kotani, D., Kuwata, T., Sato, E., Kawazoe, A., ... & Shitara, K. (2018). Targeting VEGFR2 with Ramucirumab strongly impacts effector/activated regulatory T cells and CD8+ T cells in the tumor microenvironment. Journal for immunotherapy of cancer, 6(1), 1-14.


Specifications

  • Immunogen
  • The details of the immunogen for this antibody are not available.
  • Host Species
  • Human
  • Derivation
  • Human
  • Type
  • IgG1 - kappa
  • Specificity
  • Tested positive against native human antigen.
  • Species Reactivity
  • Human
  • Applications
  • FC, IHC
  • Trade name
  • Cyramza
  • CAS
  • 947687-13-0
  • Generic Name
  • Ramucirumab
  • UNII
  • D99YVK4L0X
  • MW
  • 143.6 kDa
  • Related Disease
  • Non-small cell lung cancers (NSCLC)

Product Property

  • Purity
  • >97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
  • Storage
  • 4°C. For long term storage, aliquot and store at -20°C. Repeated thawing and freezing must be avoided.

Applications

  • Application Notes
  • The VEGF Receptor 2 antibody has been reported in applications of Immunohistochemistry, Flow Cytometry.

Target

  • Alternative Names
  • Ramucirumab;Cyramza;947687-13-0;IMC-1121B;LY3009806;IMC-1121B;Cyramza;KDR;kinase insert domain receptor (a type III receptor tyrosine kinase);vascular endothelial growth factor receptor 2;CD309;FLK1;VEGFR;VEGFR2;soluble VEGFR2;fetal liver kinase 1;fetal l

Related Resources

  • Biosimilar Overview
Please refer to Ramucirumab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Ramucirumab.

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "Ramucirumab"

Afuco™ Anti-KDR ADCC Recombinant Antibody (Ramucirumab), ADCC Enhanced
This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant monoclonal antibody to VEGF Receptor 2. Ramucirumab (IMC-1121B) is a fully human monoclonal antibody (IgG1) for the treatment of solid tumors. It is directed against the vascular endothelial growth factor receptor 2 (VEGFR2). By binding to VEGFR2 it works as a receptor antagonist blocking the binding of vascular endothelial growth factor (VEGF) to VEGFR2. VEGFR2 is known to mediate the majority of the downstream effects of VEGF in angiogenesis.

See other products for "KDR"

Intrabody

CAT Product Name Application Type
IAB-B066(A) Recombinant Anti-human KDR Intrabody [(D-Arg)9] FC, IF, FuncS scFv-(D-Arg)9
IAB-B066(G) Recombinant Anti-human KDR Intrabody [+36 GFP] CO-IP, FuncS scFv-(+36GFP)
IAB-B066(T) Recombinant Anti-human KDR Intrabody [Tat] IF, ELISA, FuncS scFv-Tat

Humanized Antibody

CAT Product Name Application Type
TAB-202 Humanized Anti-KDR Recombinant Antibody (clone Alacizumab); di - Fab' Fragment IF, IP, Neut, FuncS, ELISA, FC, ICC Humanized (from mouse) di - Fab'
TAB-411CQ Anti-Human KDR Recombinant Antibody (HLX06) ELISA Humanized antibody
TAB-411CQ-S(P) Anti-Human KDR Recombinant Antibody scFv Fragment (HLX06) ELISA Humanized antibody
TAB-411CQ-F(E) Anti-Human KDR Recombinant Antibody Fab Fragment (HLX06) ELISA Humanized antibody

Immunotoxin

CAT Product Name Application Type
AGTO-G047E Anti-KDR immunotoxin (IgG1)-PE Cytotoxicity assay, Function study

Human Antibody

CAT Product Name Application Type
TAB-0298CL-F(E) Human Anti-KDR Recombinant Antibody; Fab Fragment (TAB-0298CL-F(E)) FC, ELISA, Inhib, Neut, FuncS Human Fab
TAB-0299CL-F(E) Human Anti-KDR Recombinant Antibody; Fab Fragment (TAB-0299CL-F(E)) WB, FC, Inhib, Neut Human Fab
TAB-325CQ-F(E) Human Anti-KDR Recombinant Antibody; Fab Fragment (TAB-325CQ-F(E)) ELISA, FC Human Fab
TAB-329CQ-F(E) Human Anti-KDR Recombinant Antibody; Fab Fragment (TAB-329CQ-F(E)) ELISA, WB, Neut Human Fab
TAB-330CQ-F(E) Mouse Anti-KDR Recombinant Antibody; Fab Fragment (TAB-330CQ-F(E)) ELISA, WB, Neut Mouse Fab

scFv Fragment Antibody

CAT Product Name Application Type
PSBC-204 Mouse Anti-KDR Recombinant Antibody (clone mAb6.64); scFv Fragment Neut, Block Mouse scFv
HPAB-N0154-YC-S(P) Mouse Anti-KDR Recombinant Antibody; scFv Fragment (HPAB-N0154-YC-S(P)) ELISA, Inhib Mouse scFv
HPAB-0016-YJ-S(P) Mouse Anti-KDR Recombinant Antibody; scFv Fragment (HPAB-0016-YJ-S(P)) RIA, ELISA Mouse scFv
HPAB-0567-WJ-S(P) Human Anti-KDR Recombinant Antibody; scFv Fragment (HPAB-0567-WJ-S(P)) ELISA, FC, WB Human scFv
HPAB-0476-FY-S(P) Mouse Anti-KDR Recombinant Antibody; scFv Fragment (HPAB-0476-FY-S(P)) Inhib Mouse scFv

Mouse Antibody

CAT Product Name Application Type
TAB-326CQ Rat Anti-Kdr Recombinant Antibody (TAB-326CQ) ELISA, IHC Rat IgG
TAB-331CQ Anti-Human KDR Recombinant Antibody (6.64) IHC
TAB-332CQ Anti-Human KDR Recombinant Antibody (4.13) ELISA, FC, IHC
TAB-326CQ-F(E) Rat Anti-Kdr Recombinant Antibody; Fab Fragment (TAB-326CQ-F(E)) ELISA, FC, WB Rat Fab
TAB-331CQ-F(E) Anti-Human KDR Recombinant Antibody Fab Fragment (6.64) ELISA, FC, IHC

Chicken IgY Antibody

CAT Product Name Application Type
BRD-0624MZ Chicken Anti-VEGFR-2 Polyclonal IgY IHC, WB Chicken antibody
BRD-0709MZ Chicken Anti-KDR Polyclonal IgY WB Chicken antibody

Neutralizing Antibody

CAT Product Name Application Type
NEUT-1619CQ Recombinant Mouse Anti-KDR Antibody (23B31) WB, IP, FC, Neut
NEUT-1620CQ Recombinant Rat Anti-Kdr Antibody (CBL840) ELISA(Cap), Neut IgG2a
NEUT-1621CQ Recombinant Rat Anti-Kdr Antibody (CBL880) Neut, WB IgG2
NEUT-1622CQ Recombinant Mouse Anti-KDR Antibody (6B11) WB, Neut IgG1
NEUT-1623CQ Recombinant Mouse Anti-KDR Antibody (CBL505) FC, CyTOF, Neut IgG1

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-1927 Hi-Affi™ Recombinant Rabbit Anti-KDR Monoclonal Antibody (DS1927AB) IHC-P IgG

Recombinant Antibody

CAT Product Name Application Type
HPAB-0097-YC Rabbit Anti-KDR Recombinant Antibody (HPAB-0097-YC) ELISA, FuncS Rabbit IgG
HPAB-0098-YC Rabbit Anti-KDR Recombinant Antibody (HPAB-0098-YC) ELISA, FuncS Rabbit IgG
HPAB-0099-YC Rabbit Anti-KDR Recombinant Antibody (HPAB-0099-YC) ELISA, FuncS Rabbit IgG
MRO-1580-CN Recombinant Rabbit Anti-KDR Monoclonal Antibody (SU03-42) WB, IF, IHC, IP Rabbit IgG
HPAB-0251-FY Human Anti-KDR Recombinant Antibody (clone 043HAb-1) ELISA Human IgG1

ADCC Enhanced Antibody

CAT Product Name Application Type
AFC-TAB-079 Afuco™ Anti-KDR ADCC Recombinant Antibody (Ramucirumab), ADCC Enhanced IP, IF, FuncS, FC, Neut, ELISA ADCC enhanced antibody

Fab Fragment Antibody

CAT Product Name Application Type
HPAB-M0126-YC-F(E) Human Anti-KDR Recombinant Antibody (clone RD); Fab Fragment ELISA Human Fab
HPAB-M0127-YC-F(E) Human Anti-KDR Recombinant Antibody (clone PCABHL3); Fab Fragment ELISA, Inhib Humanized Fab
HPAB-M0128-YC-F(E) Human Anti-KDR Recombinant Antibody (clone PCABHL5); Fab Fragment ELISA, Inhib Humanized Fab
HPAB-M0129-YC-F(E) Human Anti-KDR Recombinant Antibody (clone PCABHL7); Fab Fragment ELISA, Inhib Humanized Fab
HPAB-M0130-YC-F(E) Human Anti-KDR Recombinant Antibody (clone H15PCABL); Fab Fragment ELISA, Inhib Humanized Fab

Single-domain Antibody

CAT Product Name Application Type
HPAB-0298-YJ-VHH Recombinant Human Anti-KDR Nano Antibody (NTV1) Inhib Human VHH

MHC Tetramer for Cancer

CAT Product Name Application Type
MHC-YF304 A*24:02/Human VEGFR (SYGVLLWEI) MHC Monomer MHC Multimer
MHC-YF772 H-2Db/Human VEGFR2/KDR fragment 1 (FSNSTNDILI) MHC Pentamer FCM

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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