Anti-Human VEGF Receptor 2 Recombinant Antibody (Ramucirumab) (CAT#: TAB-079)
Recombinant monoclonal antibody to VEGF Receptor 2. Ramucirumab (IMC-1121B) is a fully human monoclonal antibody (IgG1) for the treatment of solid tumors. It is directed against the vascular endothelial growth factor receptor 2 (VEGFR2). By binding to VEGFR2 it works as a receptor antagonist blocking the binding of vascular endothelial growth factor (VEGF) to VEGFR2. VEGFR2 is known to mediate the majority of the downstream effects of VEGF in angiogenesis.
Host: Human
Isotype: IgG1 - kappa
Applications: FC, IHC
Specific Inquiry
FC
Figure 1 Impact of anti-VEGFR2 blockade on PBMCs in vitro.
VEGFR2 expression in several T-cell subsets.
Tada, Y., Togashi, Y., Kotani, D., Kuwata, T., Sato, E., Kawazoe, A., ... & Shitara, K. (2018). Targeting VEGFR2 with Ramucirumab strongly impacts effector/activated regulatory T cells and CD8+ T cells in the tumor microenvironment. Journal for immunotherapy of cancer, 6(1), 1-14.
Specifications
- Immunogen
- The details of the immunogen for this antibody are not available.
- Host Species
- Human
- Derivation
- Human
- Type
- IgG1 - kappa
- Specificity
- Tested positive against native human antigen.
- Species Reactivity
- Human
- Applications
- FC, IHC
- Trade name
- Cyramza
- CAS
- 947687-13-0
- Generic Name
- Ramucirumab
- UNII
- D99YVK4L0X
- MW
- 143.6 kDa
- Related Disease
- Non-small cell lung cancers (NSCLC)
Product Property
- Purity
- >97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
- Storage
- 4°C. For long term storage, aliquot and store at -20°C. Repeated thawing and freezing must be avoided.
Applications
- Application Notes
- The VEGF Receptor 2 antibody has been reported in applications of Immunohistochemistry, Flow Cytometry.
Target
- Alternative Names
- Ramucirumab;Cyramza;947687-13-0;IMC-1121B;LY3009806;IMC-1121B;Cyramza;KDR;kinase insert domain receptor (a type III receptor tyrosine kinase);vascular endothelial growth factor receptor 2;CD309;FLK1;VEGFR;VEGFR2;soluble VEGFR2;fetal liver kinase 1;fetal l
- Gene ID
- 3791
- UniProt ID
- P35968
Related Resources
Please refer to Ramucirumab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Ramucirumab.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "Ramucirumab"
Afuco™ Anti-KDR ADCC Recombinant Antibody (Ramucirumab), ADCC EnhancedThis product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant monoclonal antibody to VEGF Receptor 2. Ramucirumab (IMC-1121B) is a fully human monoclonal antibody (IgG1) for the treatment of solid tumors. It is directed against the vascular endothelial growth factor receptor 2 (VEGFR2). By binding to VEGFR2 it works as a receptor antagonist blocking the binding of vascular endothelial growth factor (VEGF) to VEGFR2. VEGFR2 is known to mediate the majority of the downstream effects of VEGF in angiogenesis.
See other products for "KDR"
Intrabody
| CAT | Product Name | Application | Type |
| IAB-B066(A) | Recombinant Anti-human KDR Intrabody [(D-Arg)9] | FC, IF, FuncS | scFv-(D-Arg)9 |
| IAB-B066(G) | Recombinant Anti-human KDR Intrabody [+36 GFP] | CO-IP, FuncS | scFv-(+36GFP) |
| IAB-B066(T) | Recombinant Anti-human KDR Intrabody [Tat] | IF, ELISA, FuncS | scFv-Tat |
Humanized Antibody
| CAT | Product Name | Application | Type |
| TAB-202 | Humanized Anti-KDR Recombinant Antibody (clone Alacizumab); di - Fab' Fragment | IF, IP, Neut, FuncS, ELISA, FC, ICC | Humanized (from mouse) di - Fab' |
| TAB-411CQ | Anti-Human KDR Recombinant Antibody (HLX06) | ELISA | Humanized antibody |
| TAB-411CQ-S(P) | Anti-Human KDR Recombinant Antibody scFv Fragment (HLX06) | ELISA | Humanized antibody |
| TAB-411CQ-F(E) | Anti-Human KDR Recombinant Antibody Fab Fragment (HLX06) | ELISA | Humanized antibody |
Immunotoxin
| CAT | Product Name | Application | Type |
| AGTO-G047E | Anti-KDR immunotoxin (IgG1)-PE | Cytotoxicity assay, Function study |
Human Antibody
| CAT | Product Name | Application | Type |
| TAB-0298CL-F(E) | Human Anti-KDR Recombinant Antibody; Fab Fragment (TAB-0298CL-F(E)) | FC, ELISA, Inhib, Neut, FuncS | Human Fab |
| TAB-0299CL-F(E) | Human Anti-KDR Recombinant Antibody; Fab Fragment (TAB-0299CL-F(E)) | WB, FC, Inhib, Neut | Human Fab |
| TAB-325CQ-F(E) | Human Anti-KDR Recombinant Antibody; Fab Fragment (TAB-325CQ-F(E)) | ELISA, FC | Human Fab |
| TAB-329CQ-F(E) | Human Anti-KDR Recombinant Antibody; Fab Fragment (TAB-329CQ-F(E)) | ELISA, WB, Neut | Human Fab |
| TAB-330CQ-F(E) | Mouse Anti-KDR Recombinant Antibody; Fab Fragment (TAB-330CQ-F(E)) | ELISA, WB, Neut | Mouse Fab |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
| PSBC-204 | Mouse Anti-KDR Recombinant Antibody (clone mAb6.64); scFv Fragment | Neut, Block | Mouse scFv |
| HPAB-N0154-YC-S(P) | Mouse Anti-KDR Recombinant Antibody; scFv Fragment (HPAB-N0154-YC-S(P)) | ELISA, Inhib | Mouse scFv |
| HPAB-0016-YJ-S(P) | Mouse Anti-KDR Recombinant Antibody; scFv Fragment (HPAB-0016-YJ-S(P)) | RIA, ELISA | Mouse scFv |
| HPAB-0567-WJ-S(P) | Human Anti-KDR Recombinant Antibody; scFv Fragment (HPAB-0567-WJ-S(P)) | ELISA, FC, WB | Human scFv |
| HPAB-0476-FY-S(P) | Mouse Anti-KDR Recombinant Antibody; scFv Fragment (HPAB-0476-FY-S(P)) | Inhib | Mouse scFv |
Mouse Antibody
| CAT | Product Name | Application | Type |
| TAB-326CQ | Rat Anti-Kdr Recombinant Antibody (TAB-326CQ) | ELISA, IHC | Rat IgG |
| TAB-331CQ | Anti-Human KDR Recombinant Antibody (6.64) | IHC | |
| TAB-332CQ | Anti-Human KDR Recombinant Antibody (4.13) | ELISA, FC, IHC | |
| TAB-326CQ-F(E) | Rat Anti-Kdr Recombinant Antibody; Fab Fragment (TAB-326CQ-F(E)) | ELISA, FC, WB | Rat Fab |
| TAB-331CQ-F(E) | Anti-Human KDR Recombinant Antibody Fab Fragment (6.64) | ELISA, FC, IHC |
Chicken IgY Antibody
| CAT | Product Name | Application | Type |
| BRD-0624MZ | Chicken Anti-VEGFR-2 Polyclonal IgY | IHC, WB | Chicken antibody |
| BRD-0709MZ | Chicken Anti-KDR Polyclonal IgY | WB | Chicken antibody |
Neutralizing Antibody
| CAT | Product Name | Application | Type |
| NEUT-1619CQ | Recombinant Mouse Anti-KDR Antibody (23B31) | WB, IP, FC, Neut | |
| NEUT-1620CQ | Recombinant Rat Anti-Kdr Antibody (CBL840) | ELISA(Cap), Neut | IgG2a |
| NEUT-1621CQ | Recombinant Rat Anti-Kdr Antibody (CBL880) | Neut, WB | IgG2 |
| NEUT-1622CQ | Recombinant Mouse Anti-KDR Antibody (6B11) | WB, Neut | IgG1 |
| NEUT-1623CQ | Recombinant Mouse Anti-KDR Antibody (CBL505) | FC, CyTOF, Neut | IgG1 |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
| MOR-1927 | Hi-Affi™ Recombinant Rabbit Anti-KDR Monoclonal Antibody (DS1927AB) | IHC-P | IgG |
Recombinant Antibody
| CAT | Product Name | Application | Type |
| HPAB-0097-YC | Rabbit Anti-KDR Recombinant Antibody (HPAB-0097-YC) | ELISA, FuncS | Rabbit IgG |
| HPAB-0098-YC | Rabbit Anti-KDR Recombinant Antibody (HPAB-0098-YC) | ELISA, FuncS | Rabbit IgG |
| HPAB-0099-YC | Rabbit Anti-KDR Recombinant Antibody (HPAB-0099-YC) | ELISA, FuncS | Rabbit IgG |
| MRO-1580-CN | Recombinant Rabbit Anti-KDR Monoclonal Antibody (SU03-42) | WB, IF, IHC, IP | Rabbit IgG |
| HPAB-0251-FY | Human Anti-KDR Recombinant Antibody (clone 043HAb-1) | ELISA | Human IgG1 |
ADCC Enhanced Antibody
| CAT | Product Name | Application | Type |
| AFC-TAB-079 | Afuco™ Anti-KDR ADCC Recombinant Antibody (Ramucirumab), ADCC Enhanced | IP, IF, FuncS, FC, Neut, ELISA | ADCC enhanced antibody |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
| HPAB-M0126-YC-F(E) | Human Anti-KDR Recombinant Antibody (clone RD); Fab Fragment | ELISA | Human Fab |
| HPAB-M0127-YC-F(E) | Human Anti-KDR Recombinant Antibody (clone PCABHL3); Fab Fragment | ELISA, Inhib | Humanized Fab |
| HPAB-M0128-YC-F(E) | Human Anti-KDR Recombinant Antibody (clone PCABHL5); Fab Fragment | ELISA, Inhib | Humanized Fab |
| HPAB-M0129-YC-F(E) | Human Anti-KDR Recombinant Antibody (clone PCABHL7); Fab Fragment | ELISA, Inhib | Humanized Fab |
| HPAB-M0130-YC-F(E) | Human Anti-KDR Recombinant Antibody (clone H15PCABL); Fab Fragment | ELISA, Inhib | Humanized Fab |
Single-domain Antibody
| CAT | Product Name | Application | Type |
| HPAB-0298-YJ-VHH | Recombinant Human Anti-KDR Nano Antibody (NTV1) | Inhib | Human VHH |
MHC Tetramer for Cancer
| CAT | Product Name | Application | Type |
| MHC-YF304 | A*24:02/Human VEGFR (SYGVLLWEI) MHC Monomer | MHC Multimer | |
| MHC-YF772 | H-2Db/Human VEGFR2/KDR fragment 1 (FSNSTNDILI) MHC Pentamer | FCM |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
* Abbreviations
AgonistAgonist
BABioassay
InhibInhibition
PGProteogenomics
StimStimulation
WBWestern Blot
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