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  • Afuco™ Anti-Human NOTCH1 ADCC Recombinant Antibody, ADCC Enhanced

Afuco™ Anti-Human NOTCH1 ADCC Recombinant Antibody, ADCC Enhanced (CAT#: AFC-661CL)

Anti-NOTCH1 ADCC Enhanced Antibody is an ADCC enhanced antibody produced by our Afuco™ platform. Notch1-specific monoclonal antibody targets the Notch1 pathway in cancer. Notch1 antibody uses as an anti-angiogenic agent to effectively inhibit tumor angiogenesis.

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Subcellular Location
Figure 1 IF staining of human cell line HaCaT
Figure 1 IF staining of human cell line HaCaT
(Immunofluorescent staining of human cell line HaCaT shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/67168/1315_F7_4_selected.jpg
Normal Tissue
Figure 2 IHC staining of human pancreas
Figure 2 IHC staining of human pancreas
(Immunohistochemical staining of human pancreas shows strong cytoplasmic positivity in exocrine glandular cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/22466/61564_A_3_3_selected.jpg
Figure 3 Cerebral cortex
Figure 3 Cerebral cortex
(Neuronal cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/8112/61559_B_8_5.jpg
Figure 4 Colon
Figure 4 Colon
(Endocrine cells Staining: Medium Intensity: Moderate Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Enterocytes Staining: Medium Intensity: Moderate Quantity:>75% Enterocytes - Microvilli Staining: Medium Intensity: Moderate Fibroblasts Staining: High Intensity: Strong Mucosal lymphoid cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Peripheral nerve/ganglion Staining: Low Intensity: Weak)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/8112/61559_A_8_3.jpg
Figure 5 Liver
Figure 5 Liver
(Hepatocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/8112/61559_A_9_4.jpg
Figure 6 Kidney
Figure 6 Kidney
(Cells in glomeruli Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Nuclear Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/8112/61559_A_8_5.jpg
Figure 7 Testis
Figure 7 Testis
(Elongated or late spermatids Staining: Medium Intensity: Moderate Quantity:>75% Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Pachytene spermatocytes Staining: Medium Intensity: Moderate Quantity:>75% Preleptotene spermatocytes Staining: Medium Intensity: Moderate Quantity:>75% Round or early spermatids Staining: Medium Intensity: Moderate Quantity:>75% Sertoli cells Staining: Low Intensity: Weak Quantity:>75% Spermatogonia cells Staining: High Intensity: Strong)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/8112/61559_A_6_6.jpg
Figure 8 Lymph node
Figure 8 Lymph node
(Non-germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/8112/61559_A_9_8.jpg
RNA Expression
Figure 9 RNA cell line category: Cell line enhanced (HaCaT, HDLM-2, HMC-1, MOLT-4)
Figure 9 RNA cell line category: Cell line enhanced (HaCaT, HDLM-2, HMC-1, MOLT-4)
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000148400-NOTCH1

Specifications

  • Host Species
  • Human
  • Derivation
  • Humanized
  • Type
  • ADCC enhanced antibody
  • Species Reactivity
  • Human
  • Related Disease
  • Cancer

Product Property

  • Purity
  • >95% as determined by analysis by RP-HPLC
  • Storage
  • Store at –20 or -70°C upon receipt. Divide antibody into aliquots prior usage and avoid multiple freeze-thaw cycles.

Target

  • Alternative Names
  • NOTCH1; AOS5; AOVD1; TAN1; hN1

Related Resources

  • Related Diseases

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "NOTCH1"

Select a product category from the dropdown menu below to view related products.
Please select product type
IgG Antibody Products Fab Antibody Products ScFv Antibody Products Mouse Antibody Products Humanized Antibody Products Human Antibody Products Blocking Antibody Products Rabbit Monoclonal Antibody Products Neuroscience Antibody Products ADCC Enhanced Antibody Products Cancer Stem Cell Biomarker Specific Antibody Products Non-Human Primate (NHP) Antibody Products
CAT Product Name Application Type
PABL-666 Human Anti-NOTCH1 Recombinant Antibody ELISA Human IgG
HPAB-0078-YC Mouse Anti-NOTCH1 Recombinant Antibody (clone OMP-52M51) IHC Mouse IgG
MRO-1102-CN Recombinant Rabbit Anti-NOTCH1 Monoclonal Antibody (CBACN-405) WB, IF, IHC, IP, FC Rabbit IgG
HPAB-0085-YJ Rat Anti-NOTCH1 Recombinant Antibody (HPAB-0085-YJ) IF, IHC, WB Rat IgG1, κ
HPAB-0681-WJ Human Anti-NOTCH1 Recombinant Antibody (clone h52M51) ELISA, WB Humanized IgG

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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