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    Anti-Human NOTCH1 Recombinant Antibody (N1wc613) (CAT#: TAB-551MZ)

    This antibody can block Notchl/Fc and Notchl ligand interaction by binding to the cell surface receptor, Notch1 receptor. It can be potentially used for treatment and diagnosis of pathological hyperproliferative oncogenic disorders associated with expression of Notch1.

    Specific Inquiry
    • Size:

    • Conjugation:

    • Endotoxin:

    • Purity:

    • Formats:

    • Isotype Switching:

    • Fc Engineering:

    • Modalities:

    Custom Production

    We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.

    Sequences:
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    Purity :
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    We require custom production
    • Published Data
    • Gene Expression
    • Datasheet
    • MSDS
    • COA
    Block

    Figure 1 shows Notch 1 mAb blocking Notchl /Fc and Notchl ligand interaction.

    Figure 1 shows Notch 1 mAb blocking Notchl /Fc and Notchl ligand interaction.

    IgG is the isotype non-blocker control and four Notch 1 ligand blocking Mabs are shown as indicated.

    ELISA

    Figue 2 shows the FACS analysis of Notch antibodies binding to (A) 293 FIpIn (TREx) cells stably expressing the different Notch paralogs.

    Figue 2 shows the FACS analysis of Notch antibodies binding to (A) 293 FIpIn (TREx) cells stably expressing the different Notch paralogs.

    FuncS

    Figure 3 shows the effect of Notch mAbs on the Jag-2-induced luciferase reporter gene activity in U2OS FIpIn TREx cells stably expressing hNotch1.

    Figure 3 shows the effect of Notch mAbs on the Jag-2-induced luciferase reporter gene activity in U2OS FIpIn TREx cells stably expressing hNotch1.


    Specifications

    • Host Species
    • Human
    • Derivation
    • Phage display library
    • Type
    • Human antibody
    • Specificity
    • Human
    • Clone
    • N1wc613
    • Applications
    • Block, ELISA, FuncS
    • Related Disease
    • Pathological hyperproliferative oncogenic disorders

    Applications

    • Application Notes
    • This antibody has been reported for use in Blocking, Enzyme-linked Immunosorbent Assay, Functional Assay.

    Target

    • Alternative Names
    • NOTCH1; AOS5; AOVD1; TAN1; hN1

    Related Resources

    • Related Diseases

    Product Notes

    This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

    • Increased sensitivity
    • Confirmed specificity
    • High repeatability
    • Excellent batch-to-batch consistency
    • Sustainable supply
    • Animal-free production

    See more details about Hi-Affi™ recombinant antibody benefits.

    Downloads

    Download resources about recombinant antibody development and antibody engineering to boost your research.

    See other products for "Clone N1wc613"

    See other products for "NOTCH1"

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    ScFv Antibody Products Mouse Antibody Products Humanized Antibody Products Human Antibody Products Blocking Antibody Products Rabbit Monoclonal Antibody Products Neuroscience Antibody Products Fab Antibody Products IgG Antibody Products ADCC Enhanced Antibody Products Cancer Stem Cell Biomarker Specific Antibody Products Non-Human Primate (NHP) Antibody Products Flow Cytometry (FC) related Reagents and Kits: Empowering Cell Function Research ScFv-Fc Chimera Products IHC Kit and Antibody Products: Precision Tools for Immunohistochemistry Extracellular Vesicle (EV) Antibody Products
    CAT Product Name Application Type
    PSBL-660 Human Anti-NOTCH1 Recombinant Antibody; scFv Fragment ELISA Human scFv
    HPAB-0078-YC-S(P) Mouse Anti-NOTCH1 Recombinant Antibody (clone OMP-52M51); scFv Fragment IHC Mouse scFv
    HPAB-0044LY-S(P) Mouse Anti-NOTCH1 Recombinant Antibody; scFv Fragment (HPAB-0044LY-S(P)) WB Mouse scfv
    HPAB-AP750-YC-S(P) Human Anti-NOTCH1 Recombinant Antibody (clone N1wc133); scFv Fragment ELISA, FC Human scFv
    HPAB-AP751-YC-S(P) Human Anti-NOTCH1 Recombinant Antibody (clone hN1wc155); scFv Fragment ELISA, FC Human scFv

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    For Research Use Only. Not For Clinical Use.

    For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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