Recombinant Anti-Human IL6 Antibody (Fab glycosylation) (CAT#: Gly-037LC)
This product is a humanized monoclonal antibody with N-glycosylation site Asn30 in the VH region. The glycosylation in VH region has no influence on antigen binding for the humanized SK2 antibody. The antibody specifically binds human IL-6 and can be potentially used in the treatment of autoimmunce disease.
Specific Inquiry
Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to vesicles.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/72821/1350_G7_3_selected.jpg
(Immunofluorescent staining of human cell line U-2 OS shows localization to vesicles.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/72821/1350_G7_3_selected.jpg
Figure 2 IHC staining of human duodenum
(Immunohistochemical staining of human duodenum shows distinct cytoplasmic positivity in subsets of immune cells.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/23406/54890_A_8_2_selected.jpg
(Immunohistochemical staining of human duodenum shows distinct cytoplasmic positivity in subsets of immune cells.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/23406/54890_A_8_2_selected.jpg
Figure 3 Cerebral cortex
(Neuronal cells Staining: Not detected Intensity: Weak Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/23406/54890_B_7_5.jpg
(Neuronal cells Staining: Not detected Intensity: Weak Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/23406/54890_B_7_5.jpg
Figure 4 Urinary bladder
(Urothelial cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/23406/54890_A_4_5.jpg
(Urothelial cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/23406/54890_A_4_5.jpg
Figure 5 Lymph node
(Non-germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/23406/54890_A_9_8.jpg
(Non-germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/23406/54890_A_9_8.jpg
Figure 6 RNA cell line category: Group enriched (BJ hTERT+, GAMG)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000136244-IL6
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000136244-IL6
Glyco-engineering
- Glycosylation site
- Asn30 in VH
- Glycosylation Type
- N-glycosylation
- Activity
- No influence on antigen-binding
Specifications
- Target
- IL-6 (Interleukin 6)
- Host Species
- Human
- Derivation
- Humanized
- Type
- Humanized antibody
- Specificity
- Human
- Clone
- Humanized SK2
- Applications
- ELISA
Target
- Alternative Names
- IL6; interleukin 6; HGF; HSF; BSF2; IL-6; IFNB2; interleukin-6; CDF; BSF-2; IFN-beta-2; interferon beta-2; interleukin BSF-2; interferon, beta 2; hybridoma growth factor; CTL differentiation factor; B-cell stimulatory factor 2; B-cell differentiation fact
- Related Disease
- Autoimmune disease
- Gene ID
- 3569
- UniProt ID
- B4DVM1
Related Resources
Inflammatory Bowel Diseases
Rheumatoid Arthritis
Graft-versus-Host Disease
AGE-RAGE Signaling Pathway in Diabetic Complications
TNF Signaling Pathway
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-239 | Anti-Human IL6 Recombinant Antibody (TAB-239) | WB, FuncS, IF, Neut, ELISA, FC, IP | IgG1 |
| TAB-0022CL-S(P) | Mouse Anti-IL6 Recombinant Antibody; scFv Fragment (TAB-0022CL-S(P)) | Elisa, In vivo, FuncS, Block | Mouse scFv |
| TAB-0023CL-S(P) | Mouse Anti-IL6 Recombinant Antibody; scFv Fragment (TAB-0023CL-S(P)) | Elisa, In vivo, FuncS, Block | Mouse scFv |
| TAB-0024CL-S(P) | Mouse Anti-IL6 Recombinant Antibody; scFv Fragment (TAB-0024CL-S(P)) | Elisa, In vivo, FuncS, Block | Mouse scFv |
| TAB-0025CL-S(P) | Mouse Anti-IL6 Recombinant Antibody; scFv Fragment (TAB-0025CL-S(P)) | Elisa, In vivo, FuncS, Block | Mouse scFv |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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