Afuco™ Anti-IL6 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-097)

Name: Afuco™ Anti-IL6 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-097)
SKU: AFC-TAB-097
Rating: 5 (1 reviews)

CAT#: AFC-TAB-097

This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant monoclonal antibody to IL6. It is a human monoclonal antibody designed for the treatment of rheumatoid arthritis.

Gene Expression

Subcellular Location Figure 1 IF staining of human cell line U-2 OS

Immunofluorescent staining of human cell line U-2 OS shows localization to vesicles.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/72821/1350_G7_3_selected.jpg

Normal Tissue Figure 2 IHC staining of human duodenum

Immunohistochemical staining of human duodenum shows distinct cytoplasmic positivity in subsets of immune cells.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/23406/54890_A_8_2_selected.jpg

Normal Tissue Figure 3 Cerebral cortex

Neuronal cells Staining: Not detected Intensity: Weak Quantity: <25% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/23406/54890_B_7_5.jpg

Normal Tissue Figure 4 Urinary bladder

Urothelial cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/23406/54890_A_4_5.jpg

Normal Tissue Figure 5 Lymph node

Non-germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/23406/54890_A_9_8.jpg

RNA Expression Figure 6 RNA cell line category: Group enriched (BJ hTERT+, GAMG)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000136244-IL6

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Specifications

Immunogen
Recombinant full length protein (Human).

Host Species
Human

Derivation
Human

Type
ADCC enhanced antibody

Species Reactivity
Human

Applications
FC, IP, ELISA, Neut, FuncS, IF

Conjugate
Unconjugated

Generic Name
Sirukumab

Related Disease
Rheumatoid arthritis (RA) (Despite Methotrexate Therapy)

Product Property

Purity
>95% by SDS-PAGE

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Alternative Names
IL6; interleukin 6 (interferon, beta 2); IFNB2; interleukin-6; BSF2; HGF; HSF; IL 6; CDF; BSF-2; IFN-beta-2; interferon beta-2; interleukin BSF-2; hybridoma growth factor; CTL differentiation factor; B-cell stimulatory factor 2;

Gene ID
3569

UniProt ID
P05231

REVIEWS AND Q&AS CITATIONS RESOURCES DOWNLOADS RELATED PRODUCTS

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Biosimilar Overview

Please refer to Sirukumab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Sirukumab.

Related Diseases

Inflammatory Bowel Diseases

Rheumatoid Arthritis

Graft-versus-Host Disease

AGE-RAGE Signaling Pathway in Diabetic Complications

Related Signaling Pathways

TNF Signaling Pathway

Downloadable Resources

Download resources about recombinant antibody development and antibody engineering to boost your research.

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

Datasheet - AFC-TAB-097.pdf

MSDS

MSDS - AFC-TAB-097.pdf

COA

Certificate of Analysis Lookup

To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.

Lot Number:

Protocol & Troubleshooting

Immunofluorescence (IF)

We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.

See other products for "Sirukumab"

Anti-Human IL6 Recombinant Antibody (Sirukumab)
Recombinant monoclonal antibody to IL6. Sirukumab (CNTO 136) is a human monoclonal antibody designed for the treatment of rheumatoid arthritis.

DrugMonitor™ Anti-Sirukumab Antibody (VS-1224-YC1096)
Sirukumab is a fully human IgG1 kappa monoclonal antibody selectively blocking circulating IL-6, used in trials for giant cell arteritis and rheumatoid arthritis. The DrugMonitor™ Anti-Sirukumab Antibody (VS-1224-YC1096) is an anti-drug antibody (ADA) against Sirukumab. This drug-based antibody is raised in mice immunized with the Sirukumab. The anti-Sirukumab antibody may be used in ELISA, pharmacokinetics (PK), and pharmacodynamics (PD) analyses, or serves as a reference standard in ADA assays. It also is an excellent tool for therapeutic drug monitoring, allowing to evaluate the drug efficacy and determine the drug concentration of the Sirukumab in samples.

See other products for "IL6"

Select a product category from the dropdown menu below to view related products.

CAT	Product Name	Application	Type
TAB-253	Anti-Human IL-6 Recombinant Antibody (Olokizumab)	WB, ELISA, FC, IP, FuncS, IF, Neut	IgG4 - kappa
TAB-0172CL-S(P)	Human Anti-IL6 Recombinant Antibody; scFv Fragment (TAB-0172CL-S(P))	ELISA, Block, In vivo	Human scFv
TAB-0173CL-S(P)	Human Anti-IL6 Recombinant Antibody; scFv Fragment (TAB-0173CL-S(P))	ELISA, Block, In vivo	Human scFv
TAB-678LC	Anti-human IL6 Recombinant Antibody (BA399) (TAB-678LC)	ELISA, FC, Inhib	Humanized antibody
TAB-678LC-F(E)	Anti-human IL6 Fab Fragment (BA399)	ELISA, FC	Humanized antibody

CAT	Product Name	Application	Type
PABL-244	Human Anti-IL6 Recombinant Antibody (clone YC136)	WB, Block, FuncS	Human IgG
MOB-0632CT	Recombinant Mouse anti-Human IL6 Monoclonal antibody (6708)	ELISA, WB
HPAB-AP702-YC	Human Anti-IL6 Recombinant Antibody (clone BA001)	ELISA, FuncS	Humanized IgG
HPAB-AP703-YC	Human Anti-IL6 Recombinant Antibody (clone BA436)	FuncS (Induce)	Humanized IgG
HPAB-AP704-YC	Human Anti-IL6 Recombinant Antibody (clone BA802)	FuncS (Induce)	Humanized IgG

CAT	Product Name	Application	Type
TAB-0026CL	Human Anti-IL6 Recombinant Antibody (TAB-0026CL)	Elisa, In vivo, FuncS, Block	Chimeric (mouse/human) IgG
TAB-0026CL-F(E)	Human Anti-IL6 Recombinant Antibody; Fab Fragment (TAB-0026CL-F(E))	Elisa, In vivo, FuncS, Block	Chimeric (mouse/human) Fab
TAB-670LC	Anti-human IL6 Recombinant Antibody (NTS) (TAB-670LC)	ELISA, Inhib	Chimeric antibody (mouse/human)
TAB-670LC-F(E)	Anti-human IL6 Fab Fragment (NTS)	ELISA	Chimeric antibody (mouse/human)
VS3-WK1519	Human Anti-IL6 Recombinant Antibody (clone CLLB8)	ELISA, FC	Chimeric (mouse/human) IgG1

CAT	Product Name	Application
TAB-669LC	Anti-human IL6 Recombinant Antibody (SK2) (TAB-669LC)	Inhib
TAB-673LC	Anti-human IL6 Recombinant Antibody	ELISA, FC
TAB-679LC	Anti-human IL6 Recombinant Antibody (MH166) (TAB-679LC)	ELISA, Inhib, FuncS
TAB-669LC-F(E)	Anti-human IL6 Fab Fragment (SK2)	ELISA
TAB-673LC-F(E)	Anti-human IL6 Fab Fragment	ELISA, FC

CAT	Product Name	Application	Type
TAB-671LC	Anti-human IL6 Recombinant Antibody (SK2a) (TAB-671LC)	Inhib	Human antibody
TAB-672LC	Anti-human IL6 Recombinant Antibody (SK2b) (TAB-672LC)	Inhib	Human antibody
TAB-674LC	Anti-human IL6 Recombinant Antibody (TAB-674LC)	ELISA, FC	Human antibody
TAB-675LC	Anti-human IL6 Recombinant Antibody (TAB-675LC)	ELISA, FC	Human antibody
TAB-676LC	Anti-human IL6 Recombinant Antibody (9C8) (TAB-676LC)	ELISA, FC, Neut	Human antibody

CAT	Product Name	Application	Type
Gly-037LC	Recombinant Anti-Human IL6 Antibody (Fab glycosylation)	ELISA	Humanized antibody

CAT	Product Name	Application	Type
Gly-197LC	Recombinant Anti-Human IL6 Antibody (Non-glycosylated)	ELISA	Humanized antibody

CAT	Product Name	Application	Type
BRD-0284MZ	Chicken Anti-Interleukin-6 Polyclonal IgY	WB, Indirect ELISA	Chicken antibody

CAT	Product Name	Application	Type
NEUT-1473CQ	Rat Anti-Il6 Recombinant Antibody (clone 20F3)	Block, ELISA, IHC-P, IP, Neut, WB	Rat IgG1
NEUT-1475CQ	Rat Anti-Il6 Recombinant Antibody (NEUT-1475CQ)	Neut	Rat IgG2a
NEUT-1476CQ	Rat Anti-Il6 Recombinant Antibody (clone CBL112)	Neut, WB	Rat IgG1
NEUT-1477CQ	Rat Anti-Il6 Recombinant Antibody (clone CBL879)	FC, IHC, IP, Neut	Rat IgG1
NEUT-1478CQ	Rat Anti-Il6 Recombinant Antibody (clone CBL901)	ELISA, FC, IF, Neut, WB	Rat IgG1, κ

CAT	Product Name	Application	Type
NEUT-1474CQ	Rat Anti-Il6 Recombinant Antibody (clone 32C11)	Block, ELISA, WB	Rat IgG2a

CAT	Product Name	Application	Type
MOR-1814	Rabbit Anti-IL6 Recombinant Antibody (clone DS1814AB)	WB	Rabbit IgG
MOR-4277	Rabbit Anti-IL6 Recombinant Antibody (clone SI360DS)	ELISA	Rabbit IgG
MOR-4622	Rabbit Anti-IL6 Recombinant Antibody (clone TH135DS)	WB, ELISA	Rabbit IgG
MOR-4623	Rabbit Anti-IL6 Recombinant Antibody (clone TH136DS)	WB	Rabbit IgG

CAT	Product Name	Application	Type
MHC-LC3429	PE-B8/Human IL6 (ILKQKIALD) MHC Tetramer	FCM
MHC-LC3430	APC-B8/Human IL6 (ILKQKIALD) MHC Tetramer	FCM

CAT	Product Name	Application	Type
NS-043CN	Human Anti-IL6 Recombinant Antibody (NS-043CN)	ELISA, WB	Human IgG1
NS-043CN-F(E)	Human Anti-IL6 Recombinant Antibody; Fab Fragment (NS-043CN-F(E))	ELISA, WB	Human Fab
NS-043CN-S(P)	Human Anti-IL6 Recombinant Antibody; scFv Fragment (NS-043CN-S(P))	ELISA, WB	Human scFv

CAT	Product Name	Application	Type
HPAB-0674-CN-S(P)	Human Anti-IL6 Recombinant Antibody (clone 9C8-N68T-T83S); scFv Fragment	ELISA, FC	Human scFv
HPAB-0089-WJ-S(P)	Human Anti-IL6 Recombinant Antibody; scFv Fragment (HPAB-0089-WJ-S(P))	ELISA, WB	Humanized scFv
HPAB-1758-FY-F(E)	Rat Anti-IL6 Recombinant Antibody; Fab Fragment (HPAB-1758-FY-F(E))	ELISA	Rat Fab
HPAB-S0076-YC-S(P)	Rabbit Anti-IL6 Recombinant Antibody; scFv Fragment (HPAB-S0076-YC-S(P))	ELISA, WB, Block, FuncS	Rabbit scFv
HPAB-S0077-YC-S(P)	Human Anti-IL6 Recombinant Antibody; scFv Fragment (HPAB-S0077-YC-S(P))	ELISA, Block	Human scFv

CAT	Product Name	Application	Type
AFC-TAB-239	Afuco™ Anti-IL6 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-239)	FuncS, IF, Neut, ELISA, FC	ADCC enhanced antibody
AFC-TAB-H26	Afuco™ Anti-IL6 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-H26)	Neut, ELISA, IF, IP, FuncS, FC	ADCC enhanced antibody
AFC-TAB-253	Afuco™ Anti-IL6 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-253)	ELISA, FC, IP, FuncS, IF	ADCC enhanced antibody

CAT	Product Name	Application	Type
HPAB-1250-FY-S(P)	Mouse Anti-IL6 Recombinant Antibody; scFv Fragment (HPAB-1250-FY-S(P))	ELISA	Mouse scFv
HPAB-1251-FY-S(P)	Mouse Anti-IL6 Recombinant Antibody; scFv Fragment (HPAB-1251-FY-S(P))	ELISA	Mouse scFv
HPAB-1252-FY-S(P)	Mouse Anti-IL6 Recombinant Antibody; scFv Fragment (HPAB-1252-FY-S(P))	ELISA	Mouse scFv
HPAB-1253-FY-S(P)	Mouse Anti-IL6 Recombinant Antibody; scFv Fragment (HPAB-1253-FY-S(P))	ELISA	Mouse scFv
HPAB-1254-FY-S(P)	Mouse Anti-IL6 Recombinant Antibody; scFv Fragment (HPAB-1254-FY-S(P))	ELISA	Mouse scFv

CAT	Product Name	Application	Type
HPAB-S0166-YC	Camelid Anti-IL6 Recombinant Single Domain Antibody (HPAB-S0166-YC)	ELISA	Camelid VHH
HPAB-S0167-YC	Camelid Anti-IL6 Recombinant Single Domain Antibody (HPAB-S0167-YC)	ELISA	Camelid VHH
HPAB-S0168-YC	Camelid Anti-IL6 Recombinant Single Domain Antibody (HPAB-S0168-YC)	ELISA, Inhib	Camelid VHH
HPAB-S0169-YC	Camelid Anti-IL6 Recombinant Single Domain Antibody (HPAB-S0169-YC)	ELISA, Inhib	Camelid VHH
HPAB-S0170-YC	Camelid Anti-IL6 Recombinant Single Domain Antibody (HPAB-S0170-YC)	ELISA, Inhib	Camelid VHH

CAT	Product Name	Application	Type
VS-0424-XY151	AbPlus™ Anti-IL6 Magnetic Beads (AS16)	IP, Protein Purification

CAT	Product Name	Application	Type
VS-1024-XY279	Mouse Anti-NHP IL6 Recombinant Antibody (clone 6708)	WB, ELISA	Mouse IgG1

CAT	Product Name	Application	Type
VS-0225-XY146	CytoStream™ Mouse Anti-IL6 Recombinant Antibody (VS-0225-XY146)	FC	Mouse IgG1

CAT	Product Name	Application	Type
VS-0425-FY11	Human Anti-IL6 (clone BA001) scFv-Fc Chimera	ELISA, Block	Human IgG1, scFv-Fc

CAT	Product Name	Application	Type
VS-0425-YC526	Recombinant Anti-IL6 Vesicular Antibody, EV Displayed (VS-0425-YC526)	ELISA, FC, Neut, Cell-uptake

CAT	Product Name	Application	Type
VS-0525-XY3537	Anti-Mouse IL6 Immunohistochemistry Kit	IHC
VS-0525-XY3538	Anti-Human IL6 Immunohistochemistry Kit	IHC

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