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    For Research Use Only. Not For Clinical Use.


    Background

    This gene encodes a cytokine that functions in inflammation and the maturation of B cells. In addition, the encoded protein has been shown to be an endogenous pyrogen capable of inducing fever in people with autoimmune diseases or infections. The protein is primarily produced at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis. Alternative splicing results in multiple transcript variants.
    IL6
    Protein class

    Cancer-related genes, Candidate cardiovascular disease genes, Disease related genes, FDA approved drug targets, Human disease related genes, Plasma proteins

    Predicted location

    Intracellular, Secreted (different isoforms)

    Single cell type specificity

    Group enriched (Fibroblasts, Smooth muscle cells, Glandular and luminal cells, Endothelial cells, Adipocytes, Endometrial ciliated cells)

    Immune cell specificity

    Group enriched (naive B-cell, memory B-cell)

    Cell line specificity

    Group enriched (BJ hTERT+, GAMG)

    Interaction

    Component of a hexamer of two molecules each of IL6, IL6R and IL6ST; first binds to IL6R to associate with the signaling subunit IL6ST (PubMed:12829785). Interacts with IL6R (via the N-terminal ectodomain); this interaction may be affected by IL6R-binding with SORL1, hence decreasing IL6 cis signaling (PubMed:28265003). Interacts with SORL1 (via the N-terminal ectodomain); this interaction leads to IL6 internalization and lysosomal degradation (PubMed:28265003). May form a trimeric complex with the soluble SORL1 ectodomain and soluble IL6R receptor; this interaction might stabilize circulating IL6, hence promoting IL6 trans signaling (PubMed:28265003).

    Molecular function

    Cytokine, Growth factor

    More Types Infomation
    Related Diseases
    Inflammatory Bowel Diseases Inflammatory Bowel Diseases
    Rheumatoid Arthritis Rheumatoid Arthritis
    Graft-versus-Host Disease Graft-versus-Host Disease
    AGE-RAGE Signaling Pathway in Diabetic Complications AGE-RAGE Signaling Pathway in Diabetic Complications
    Related Signaling Pathways
    TNF Signaling Pathway TNF Signaling Pathway
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