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IL6

Engineered Antibody Antibody-like Scaffold Protein Glyco-Abs MHC
Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation Acts on B-cells, T-cells, hepatocytes, hematopoeitic progenitor cells and cells of the CNS. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance.
Protein class

Cancer-related genes
Candidate cardiovascular disease genes
Disease related genes
FDA approved drug targets
Human disease related genes
Plasma proteins

Predicted location

Intracellular, Secreted

Single cell type specificity

Group enriched (Fibroblasts, Smooth muscle cells, Glandular and luminal cells, Endothelial cells, Adipocytes, Endometrial ciliated cells)

Immune cell specificity

Group enriched (naive B-cell, memory B-cell)

Cell line specificity

Group enriched (BJ hTERT+, GAMG)

Interaction

Component of a hexamer of two molecules each of IL6, IL6R and IL6ST; first binds to IL6R to associate with the signaling subunit IL6ST (PubMed:12829785).
Interacts with IL6R (via the N-terminal ectodomain); this interaction may be affected by IL6R-binding with SORL1, hence decreasing IL6 cis signaling (PubMed:28265003).
Interacts with SORL1 (via the N-terminal ectodomain); this interaction leads to IL6 internalization and lysosomal degradation (PubMed:28265003). May form a trimeric complex with the soluble SORL1 ectodomain and soluble IL6R receptor; this interaction might stabilize circulating IL6, hence promoting IL6 trans signaling (PubMed:28265003).

Molecular function

Cytokine, Growth factor

More Types Infomation
Related Diseases
Inflammatory Bowel Diseases
Rheumatoid Arthritis
Graft-versus-Host Disease
AGE-RAGE Signaling Pathway in Diabetic Complications
Related Signaling Pathways
TNF Signaling Pathway

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