Candidate cardiovascular disease genes
Disease related genes
FDA approved drug targets
Human disease related genes
Group enriched (Fibroblasts, Smooth muscle cells, Glandular and luminal cells, Endothelial cells, Adipocytes, Endometrial ciliated cells)
Group enriched (naive B-cell, memory B-cell)
Group enriched (BJ hTERT+, GAMG)
Component of a hexamer of two molecules each of IL6, IL6R and IL6ST; first binds to IL6R to associate with the signaling subunit IL6ST (PubMed:12829785).
Interacts with IL6R (via the N-terminal ectodomain); this interaction may be affected by IL6R-binding with SORL1, hence decreasing IL6 cis signaling (PubMed:28265003).
Interacts with SORL1 (via the N-terminal ectodomain); this interaction leads to IL6 internalization and lysosomal degradation (PubMed:28265003). May form a trimeric complex with the soluble SORL1 ectodomain and soluble IL6R receptor; this interaction might stabilize circulating IL6, hence promoting IL6 trans signaling (PubMed:28265003).
Cytokine, Growth factor
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For Research Use Only. Not For Clinical Use.