Anti-Human IL6 Recombinant Antibody (Sirukumab) (CAT#: TAB-097)
Recombinant monoclonal antibody to IL6. Sirukumab (CNTO 136) is a human monoclonal antibody designed for the treatment of rheumatoid arthritis.
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ELISA
Figure 1 Anti-Human IL6 Recombinant Antibody (TAB-097) in ELISA
ELISA analysis of TAB-097 was performed by coating with human IL6 protein (His tag). Then blocked with BSA and incubated with TAB-097. The HRP-conjugated goat anti-IgG was used as a secondary antibody (1: 2000). Detection was performed using TMB substrate and stopped with sulfuric acid. The absorbances were read on a spectrophotometer at 450 nm.
WB
Figure 2 Anti-Human IL6 Recombinant Antibody (TAB-097) in WB
Western blot analysis of TAB-097 was performed by loading human IL6 protein onto a 12% Tris-HCl polyacrylamide gel. Proteins were transferred to a CN membrane and blocked with 5% skim milk for at least one hour. Membranes were probed with TAB-097 and a HRP goat anti-IgG (H+L) was used as the secondary antibody (1: 3000). Chemiluminescent detection was performed.
DB
Figure 3 Anti-Human IL6 Recombinant Antibody (TAB-097) in DB
Dot Blot analysis of TAB-097 was performed by coating with human IL6 protein (His tag).
TAB-097 incubation concentration: 2 μg/mL.
HRP-conjugated goat anti-IgG (H+L) secondary antibody (1: 3000)
NC: Negative control, PC: Positive control
Specifications
- Immunogen
- Recombinant full length protein (Human).
- Host Species
- Human
- Derivation
- Human
- Type
- IgG1 - kappa
- Specificity
- Tested positive against native human antigen.
- Species Reactivity
- Human
- Applications
- FC, IP, ELISA, Neut, FuncS, IF, WB
- CAS
- 1194585-53-9
- Generic Name
- Sirukumab
- MW
- 144.6 kDa
- Related Disease
- Rheumatoid arthritis (RA) (Despite Methotrexate Therapy)
Product Property
- Purity
- >95.0% as determined by analysis by SDS-PAGE.
- Storage
- Store it under sterile conditions at -20°C upon receiving. Recommend to pack the protein into smaller quantities for optimal storage.
Applications
- Application Notes
- The IL6 antibody has been reported in applications of PK.
Target
- Alternative Names
- Sirukumab;1194585-53-9;CNTO 136;AME-19A;IL6;interleukin 6 (interferon, beta 2);IFNB2;interleukin-6;BSF2;HGF;HSF;IL 6;CDF;BSF-2;IFN-beta-2;interferon beta-2;interleukin BSF-2;hybridoma growth factor;CTL differentiation factor;B-cell stimulatory factor 2;B-
- Gene ID
- 3569
- UniProt ID
- P05231
Related Resources
Please refer to Sirukumab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Sirukumab.
Inflammatory Bowel Diseases
Rheumatoid Arthritis
Graft-versus-Host Disease
AGE-RAGE Signaling Pathway in Diabetic Complications
TNF Signaling Pathway
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
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Afuco™ Anti-IL6 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-097)This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant monoclonal antibody to IL6. It is a human monoclonal antibody designed for the treatment of rheumatoid arthritis.
DrugMonitor™ Anti-Sirukumab Antibody (VS-1224-YC1096)Sirukumab is a fully human IgG1 kappa monoclonal antibody selectively blocking circulating IL-6, used in trials for giant cell arteritis and rheumatoid arthritis. The DrugMonitor™ Anti-Sirukumab Antibody (VS-1224-YC1096) is an anti-drug antibody (ADA) against Sirukumab. This drug-based antibody is raised in mice immunized with the Sirukumab. The anti-Sirukumab antibody may be used in ELISA, pharmacokinetics (PK), and pharmacodynamics (PD) analyses, or serves as a reference standard in ADA assays. It also is an excellent tool for therapeutic drug monitoring, allowing to evaluate the drug efficacy and determine the drug concentration of the Sirukumab in samples.
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IHC Kits & Antibodies
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-253 | Anti-Human IL-6 Recombinant Antibody (Olokizumab) | WB, ELISA, FC, IP, FuncS, IF, Neut | IgG4 - kappa |
| TAB-0172CL | Human Anti-IL6 Recombinant Antibody (TAB-0172CL) | ELISA, Block, In vivo | Human IgG |
| TAB-0173CL | Human Anti-IL6 Recombinant Antibody (TAB-0173CL) | ELISA, Block, In vivo | Human IgG1 |
| TAB-0172CL-S(P) | Human Anti-IL6 Recombinant Antibody; scFv Fragment (TAB-0172CL-S(P)) | ELISA, Block, In vivo | Human scFv |
| TAB-678LC | Anti-human IL6 Recombinant Antibody (BA399) (TAB-678LC) | ELISA, FC, Inhib | Humanized antibody |
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