Human Anti-IL6 (clone BA001) scFv-Fc Chimera
CAT#: VS-0425-FY11
The anti-IL6 scFv-Fc is a specialized therapeutic agent that targets Interleukin-6 (IL-6), a cytokine involved in inflammation and immune regulation. By inhibiting IL-6 signaling, this scFv-Fc construct helps in the management of chronic inflammatory diseases, such as rheumatoid arthritis and various types of cancer. The fusion of antibody fragments with an Fc region ensures enhanced stability and bioavailability, facilitating effective neutralization of IL-6 in biological systems. This product aims to improve patient outcomes by reducing IL-6-driven inflammation and associated pathologies. Its mechanism of action provides a promising strategy for developing targeted therapies in inflammatory conditions.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to vesicles.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/72821/1350_G7_3_selected.jpg
Normal Tissue
Figure 2 IHC staining of human duodenum
Immunohistochemical staining of human duodenum shows distinct cytoplasmic positivity in subsets of immune cells.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/23406/54890_A_8_2_selected.jpg
Normal Tissue
Figure 3 Cerebral cortex
Neuronal cells Staining: Not detected Intensity: Weak Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/23406/54890_B_7_5.jpg
Normal Tissue
Figure 4 Urinary bladder
Urothelial cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/23406/54890_A_4_5.jpg
Normal Tissue
Figure 5 Lymph node
Non-germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/23406/54890_A_9_8.jpg
RNA Expression
Figure 6 RNA cell line category: Group enriched (BJ hTERT+, GAMG)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000136244-IL6
❮
❯
Specifications
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- Human IL6
- Species Reactivity
- Human
- Clone
- BA001
- Applications
- ELISA, Blocking
- Related Disease
- Crohn's disease
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- The optimal dilution concentration is determined by the experiment.
Target
- Alternative Names
- Interleukin 6
- Gene ID
- 3569
- UniProt ID
- P05231
- Long Name
- Interleukin 6
- Sequence Similarities
- Belongs to the IL-6 superfamily.
- Cellular Localization
- Secreted
- Post Translation Modifications
- N- and O-glycosylated.
Glycosylation at Asn73
Modification sites at PhosphoSitePlus
Glycosylation from GlyGen
- Protein Refseq
- XP_005249802.1; XP_054214120.1; XP_054214121.1; NP_000591.1; NP_001305024.1
- Function
- Cytokine with a wide variety of biological functions in immunity, tissue regeneration, and metabolism.
Binds to IL6R, then the complex associates to the signaling subunit IL6ST/gp130 to trigger the intracellular IL6-signaling pathway (Probable).
The interaction with the membrane-bound IL6R and IL6ST stimulates 'classic signaling', whereas the binding of IL6 and soluble IL6R to IL6ST stimulates 'trans-signaling'.
REVIEWS AND Q&AS
CITATIONS
RESOURCES
DOWNLOADS
RELATED PRODUCTS
Inquiry
Navs
Customer Review
There are currently no Customer reviews or questions for VS-0425-FY11. Click the button above to contact us or submit your feedback about this product.
Submit Your Publication
Published with our product? Submit your paper and receive a 10% discount on your next order! Share your research to earn exclusive rewards.
Related Diseases
Inflammatory Bowel Diseases
Rheumatoid Arthritis
Graft-versus-Host Disease
AGE-RAGE Signaling Pathway in Diabetic Complications
Related Signaling Pathways
TNF Signaling Pathway
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "Clone BA001"
- CAT
- Product Name
See other products for "IL6"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-239 | Anti-Human IL6 Recombinant Antibody (TAB-239) | WB, FuncS, IF, Neut, ELISA, FC, IP | IgG1 |
| TAB-0022CL | Mouse Anti-IL6 Recombinant Antibody (TAB-0022CL) | Elisa, In vivo, FuncS, Block | Mouse IgG |
| TAB-669LC-F(E) | Anti-human IL6 Fab Fragment (SK2) | ELISA | |
| TAB-673LC-F(E) | Anti-human IL6 Fab Fragment | ELISA, FC | |
| TAB-679LC-F(E) | Anti-human IL6 Fab Fragment (MH166) | ELISA |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-253 | Anti-Human IL-6 Recombinant Antibody (Olokizumab) | WB, ELISA, FC, IP, FuncS, IF, Neut | IgG4 - kappa |
| TAB-0172CL | Human Anti-IL6 Recombinant Antibody (TAB-0172CL) | ELISA, Block, In vivo | Human IgG |
| TAB-0173CL | Human Anti-IL6 Recombinant Antibody (TAB-0173CL) | ELISA, Block, In vivo | Human IgG1 |
| TAB-678LC-S(P) | Anti-human IL6 scFv Fragment (BA399) | ELISA, FC | Humanized antibody |
| TAB-678LC-F(E) | Anti-human IL6 Fab Fragment (BA399) | ELISA, FC | Humanized antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-097 | Anti-Human IL6 Recombinant Antibody (Sirukumab) | FC, IP, ELISA, Neut, FuncS, IF, WB | IgG1 - kappa |
| TAB-671LC-F(E) | Anti-human IL6 Fab Fragment (SK2a) | ELISA | Human antibody |
| TAB-672LC-F(E) | Anti-human IL6 Fab Fragment (SK2b) | ELISA | Human antibody |
| TAB-674LC-F(E) | Anti-human IL6 Fab Fragment (TAB-674LC-F(E)) | ELISA, FC | Human antibody |
| TAB-675LC-F(E) | Anti-human IL6 Fab Fragment (TAB-675LC-F(E)) | ELISA, FC | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABL-244 | Human Anti-IL6 Recombinant Antibody (clone YC136) | WB, Block, FuncS | Human IgG |
| PABL-618 | Recombinant Human Anti-IL-6 Antibody | ELISA, Neut | IgG |
| HPAB-588-FY | Human Anti-IL6 Recombinant Antibody (HPAB-588-FY) | FC, ELISA | Human IgG2 |
| HPAB-591-FY | Human Anti-IL6 Recombinant Antibody (HPAB-591-FY) | Inhib | Human IgG1 |
| HPAB-AP702-YC | Human Anti-IL6 Recombinant Antibody (clone BA001) | ELISA, FuncS | Humanized IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0026CL-S(P) | Mouse Anti-IL6 Recombinant Antibody; scFv Fragment (TAB-0026CL-S(P)) | Elisa, In vivo, FuncS, Block | Mouse scFv |
| TAB-0026CL-F(E) | Human Anti-IL6 Recombinant Antibody; Fab Fragment (TAB-0026CL-F(E)) | Elisa, In vivo, FuncS, Block | Chimeric (mouse/human) Fab |
| TAB-670LC | Anti-human IL6 Recombinant Antibody (NTS) (TAB-670LC) | ELISA, Inhib | Chimeric antibody (mouse/human) |
| TAB-670LC-F(E) | Anti-human IL6 Fab Fragment (NTS) | ELISA | Chimeric antibody (mouse/human) |
| VS3-WK1519 | Human Anti-IL6 Recombinant Antibody (clone CLLB8) | ELISA, FC | Chimeric (mouse/human) IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-037LC | Recombinant Anti-Human IL6 Antibody (Fab glycosylation) | ELISA | Humanized antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-197LC | Recombinant Anti-Human IL6 Antibody (Non-glycosylated) | ELISA | Humanized antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0284MZ | Chicken Anti-Interleukin-6 Polyclonal IgY | WB, Indirect ELISA | Chicken antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1471CQ | Mouse Anti-IL6 Recombinant Antibody (clone CBL713) | ICC, ICFC, Neut | Mouse IgG2b |
| NEUT-1472CQ | Mouse Anti-IL6 Recombinant Antibody (clone AS16) | IHC, IP, Neut | Mouse IgG1 |
| NEUT-1473CQ | Rat Anti-Il6 Recombinant Antibody (clone 20F3) | Block, ELISA, IHC-P, IP, Neut, WB | Rat IgG1 |
| NEUT-1475CQ | Rat Anti-Il6 Recombinant Antibody (NEUT-1475CQ) | Neut | Rat IgG2a |
| NEUT-1476CQ | Rat Anti-Il6 Recombinant Antibody (clone CBL112) | Neut, WB | Rat IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1474CQ | Rat Anti-Il6 Recombinant Antibody (clone 32C11) | Block, ELISA, WB | Rat IgG2a |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1814 | Rabbit Anti-IL6 Recombinant Antibody (clone DS1814AB) | WB | Rabbit IgG |
| MOR-4277 | Rabbit Anti-IL6 Recombinant Antibody (clone SI360DS) | ELISA | Rabbit IgG |
| MOR-4622 | Rabbit Anti-IL6 Recombinant Antibody (clone TH135DS) | WB, ELISA | Rabbit IgG |
| MOR-4623 | Rabbit Anti-IL6 Recombinant Antibody (clone TH136DS) | WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-LC3429 | PE-B8/Human IL6 (ILKQKIALD) MHC Tetramer | FCM | |
| MHC-LC3430 | APC-B8/Human IL6 (ILKQKIALD) MHC Tetramer | FCM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0017-YC-F(E) | Human Anti-IL6 Recombinant Antibody; Fab Fragment (HPAB-0017-YC-F(E)) | ELISA, Block | Human Fab |
| HPAB-0674-CN-F(E) | Human Anti-IL6 Recombinant Antibody (clone 9C8-N68T-T83S); Fab Fragment | ELISA, FC | Human Fab |
| HPAB-588-FY-F(E) | Human Anti-IL6 Recombinant Antibody; Fab Fragment (HPAB-588-FY-F(E)) | ELISA | Human Fab |
| HPAB-591-FY-F(E) | Human Anti-IL6 Recombinant Antibody; Fab Fragment (HPAB-591-FY-F(E)) | ELISA | Human Fab |
| HPAB-1562-FY-S(P) | Human Anti-IL6 Recombinant Antibody; scFv Fragment (HPAB-1562-FY-S(P)) | WB, ELISA, Neut | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NS-043CN | Human Anti-IL6 Recombinant Antibody (NS-043CN) | ELISA, WB | Human IgG1 |
| NS-043CN-F(E) | Human Anti-IL6 Recombinant Antibody; Fab Fragment (NS-043CN-F(E)) | ELISA, WB | Human Fab |
| NS-043CN-S(P) | Human Anti-IL6 Recombinant Antibody; scFv Fragment (NS-043CN-S(P)) | ELISA, WB | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-239 | Afuco™ Anti-IL6 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-239) | FuncS, IF, Neut, ELISA, FC | ADCC enhanced antibody |
| AFC-TAB-097 | Afuco™ Anti-IL6 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-097) | FC, IP, ELISA, Neut, FuncS, IF | ADCC enhanced antibody |
| AFC-TAB-H26 | Afuco™ Anti-IL6 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-H26) | Neut, ELISA, IF, IP, FuncS, FC | ADCC enhanced antibody |
| AFC-TAB-253 | Afuco™ Anti-IL6 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-253) | ELISA, FC, IP, FuncS, IF | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0877-FY-F(E) | Human Anti-IL6 Recombinant Antibody; Fab Fragment (HPAB-0877-FY-F(E)) | ELISA | Human Fab |
| HPAB-AP702-YC-S(P) | Human Anti-IL6 Recombinant Antibody (clone BA001); scFv Fragment | ELISA, FuncS | Human scFv |
| HPAB-AP703-YC-S(P) | Human Anti-IL6 Recombinant Antibody (clone BA436); scFv Fragment | FuncS (Induce) | Human scFv |
| HPAB-AP704-YC-S(P) | Human Anti-IL6 Recombinant Antibody (clone BA802); scFv Fragment | FuncS (Induce) | Human scFv |
| HPAB-AP705-YC-S(P) | Human Anti-IL6 Recombinant Antibody (clone BA808); scFv Fragment | FuncS (Induce) | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-S0166-YC | Camelid Anti-IL6 Recombinant Single Domain Antibody (HPAB-S0166-YC) | ELISA | Camelid VHH |
| HPAB-S0167-YC | Camelid Anti-IL6 Recombinant Single Domain Antibody (HPAB-S0167-YC) | ELISA | Camelid VHH |
| HPAB-S0168-YC | Camelid Anti-IL6 Recombinant Single Domain Antibody (HPAB-S0168-YC) | ELISA, Inhib | Camelid VHH |
| HPAB-S0169-YC | Camelid Anti-IL6 Recombinant Single Domain Antibody (HPAB-S0169-YC) | ELISA, Inhib | Camelid VHH |
| HPAB-S0170-YC | Camelid Anti-IL6 Recombinant Single Domain Antibody (HPAB-S0170-YC) | ELISA, Inhib | Camelid VHH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0424-XY151 | AbPlus™ Anti-IL6 Magnetic Beads (AS16) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1024-XY279 | Mouse Anti-NHP IL6 Recombinant Antibody (clone 6708) | WB, ELISA | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0225-XY146 | CytoStream™ Mouse Anti-IL6 Recombinant Antibody (VS-0225-XY146) | FC | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC526 | Recombinant Anti-IL6 Vesicular Antibody, EV Displayed (VS-0425-YC526) | ELISA, FC, Neut, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY3537 | Anti-Mouse IL6 Immunohistochemistry Kit | IHC | |
| VS-0525-XY3538 | Anti-Human IL6 Immunohistochemistry Kit | IHC |
Specific Inquiry
Add to compare
See Our Custom Production in Action
Popular Products
Application: WB, FC, IP, ELISA, Neut, FuncS, IF
Application: Neut, ELISA, IF, IP, FuncS, FC, ICC
Application: IF, IP, Neut, FuncS, ELISA, FC, ICC
Application: FuncS, IF, Neut, ELISA, FC, IP, IHC
Application: ELISA, FC, IP, FuncS, IF, Neut, ICC
Application:
Application: ELISA
Application: IF, IP, Neut, FuncS, ELISA, FC
Application: Neut, FuncS, IHC, ELISA, FC, Inhib
Application: ELISA, FuncS
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
