Anti-Human IL6 Recombinant Antibody (TAB-239) (CAT#: TAB-239)
Recombinant monoclonal antibody to IL-6. It is a mouse monoclonal antibody and an immunosuppressive drug. It targets and blocks Interleukin-6. It has undergone a number of early stage clinical trails, e.g. for lymphoma and myeloma. It was used as a template to develop a high-affinity, antagonist, fully human anti-IL-6 mAb 1339.
Specific Inquiry
Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to vesicles.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/72821/1350_G7_3_selected.jpg
(Immunofluorescent staining of human cell line U-2 OS shows localization to vesicles.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/72821/1350_G7_3_selected.jpg
Figure 2 IHC staining of human duodenum
(Immunohistochemical staining of human duodenum shows distinct cytoplasmic positivity in subsets of immune cells.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/23406/54890_A_8_2_selected.jpg
(Immunohistochemical staining of human duodenum shows distinct cytoplasmic positivity in subsets of immune cells.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/23406/54890_A_8_2_selected.jpg
Figure 3 Cerebral cortex
(Neuronal cells Staining: Not detected Intensity: Weak Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/23406/54890_B_7_5.jpg
(Neuronal cells Staining: Not detected Intensity: Weak Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/23406/54890_B_7_5.jpg
Figure 4 Urinary bladder
(Urothelial cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/23406/54890_A_4_5.jpg
(Urothelial cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/23406/54890_A_4_5.jpg
Figure 5 Lymph node
(Non-germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/23406/54890_A_9_8.jpg
(Non-germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/23406/54890_A_9_8.jpg
Figure 6 RNA cell line category: Group enriched (BJ hTERT+, GAMG)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000136244-IL6
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000136244-IL6
Specifications
- Immunogen
- The details of the immunogen for this antibody are not available.
- Host Species
- Mouse
- Derivation
- Mouse
- Type
- IgG1
- Specificity
- Tested positive against native human antigen.
- Species Reactivity
- Human
- Applications
- Suitable for use in WB, FuncS, IF, Neut, ELISA, FC, IP and most other immunological methods.
- Related Disease
- Cancers
Product Property
- Purity
- >95.0%. Determined by analysis by RP-HPLC & analysis by SDS-PAGE.
- Storage
- At -20°C for one year.
Target
- Alternative Names
- Elsilimomab;B-E8;B-E8;IL6;interleukin 6 (interferon, beta 2);IFNB2;interleukin-6;BSF2;HGF;HSF;IL 6;CDF;BSF-2;IFN-beta-2;interferon beta-2;interleukin BSF-2;hybridoma growth factor;CTL differentiation factor;B-cell stimulatory factor 2;B-cell differentiati
- Gene ID
- 3569
- UniProt ID
- P05231
Related Resources
Please refer to Elsilimomab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Elsilimomab.
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Rheumatoid Arthritis
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TNF Signaling Pathway
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
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Flow Cytometry (FC) related Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-253 | Anti-Human IL-6 Recombinant Antibody (Olokizumab) | WB, ELISA, FC, IP, FuncS, IF, Neut | IgG4 - kappa |
| TAB-0172CL-F(E) | Human Anti-IL6 Recombinant Antibody; Fab Fragment (TAB-0172CL-F(E)) | ELISA, Block, In vivo | Humanized Fab |
| TAB-0173CL-F(E) | Human Anti-IL6 Recombinant Antibody; Fab Fragment (TAB-0173CL-F(E)) | ELISA, Block, In vivo | Humanized Fab |
| TAB-678LC | Anti-human IL6 Recombinant Antibody (BA399) (TAB-678LC) | ELISA, FC, Inhib | Humanized antibody |
| TAB-678LC-S(P) | Anti-human IL6 scFv Fragment (BA399) | ELISA, FC | Humanized antibody |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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