Anti-Human IL6 Recombinant Antibody (TAB-239)
CAT#: TAB-239
Recombinant monoclonal antibody to IL-6. It is a mouse monoclonal antibody and an immunosuppressive drug. It targets and blocks Interleukin-6. It has undergone a number of early stage clinical trails, e.g. for lymphoma and myeloma. It was used as a template to develop a high-affinity, antagonist, fully human anti-IL-6 mAb 1339.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to vesicles.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/72821/1350_G7_3_selected.jpg
Normal Tissue
Figure 2 IHC staining of human duodenum
Immunohistochemical staining of human duodenum shows distinct cytoplasmic positivity in subsets of immune cells.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/23406/54890_A_8_2_selected.jpg
Normal Tissue
Figure 3 Cerebral cortex
Neuronal cells Staining: Not detected Intensity: Weak Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/23406/54890_B_7_5.jpg
Normal Tissue
Figure 4 Urinary bladder
Urothelial cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/23406/54890_A_4_5.jpg
Normal Tissue
Figure 5 Lymph node
Non-germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/23406/54890_A_9_8.jpg
RNA Expression
Figure 6 RNA cell line category: Group enriched (BJ hTERT+, GAMG)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000136244-IL6
❮
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Specifications
- Immunogen
- The details of the immunogen for this antibody are not available.
- Host Species
- Mouse
- Derivation
- Mouse
- Type
- IgG1
- Specificity
- Tested positive against native human antigen.
- Species Reactivity
- Human
- Applications
- Suitable for use in WB, FuncS, IF, Neut, ELISA, FC, IP and most other immunological methods.
- Related Disease
- Cancers
Product Property
- Purity
- >95.0%. Determined by analysis by RP-HPLC & analysis by SDS-PAGE.
- Storage
- At -20°C for one year.
Target
- Alternative Names
- Elsilimomab;B-E8;B-E8;IL6;interleukin 6 (interferon, beta 2);IFNB2;interleukin-6;BSF2;HGF;HSF;IL 6;CDF;BSF-2;IFN-beta-2;interferon beta-2;interleukin BSF-2;hybridoma growth factor;CTL differentiation factor;B-cell stimulatory factor 2;B-cell differentiati
- Gene ID
- 3569
- UniProt ID
- P05231
REVIEWS AND Q&AS
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Biosimilar Overview
Please refer to Elsilimomab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Elsilimomab.
Related Diseases
Inflammatory Bowel Diseases
Rheumatoid Arthritis
Graft-versus-Host Disease
AGE-RAGE Signaling Pathway in Diabetic Complications
Related Signaling Pathways
TNF Signaling Pathway
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
See other products for "IL6"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0249MC | Rabbit Anti-IL6 Antibody | WB, ELISA | |
| MRO-1969-CN | Rabbit Anti-IL6 Polyclonal Antibody (MRO-1969-CN) | WB, ELISA | Rabbit IgG |
| MRO-1970-CN | Rabbit Anti-IL6 Polyclonal Antibody (MRO-1970-CN) | WB, IF, IHC, FC | Rabbit IgG |
| HPAB-588-FY | Human Anti-IL6 Recombinant Antibody (HPAB-588-FY) | FC, ELISA | Human IgG2 |
| HPAB-591-FY | Human Anti-IL6 Recombinant Antibody (HPAB-591-FY) | Inhib | Human IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBL-244 | Human Anti-IL6 Recombinant Antibody (clone YC136); scFv Fragment | WB, Block, FuncS | Human scFv |
| HPAB-588-FY-S(P) | Human Anti-IL6 Recombinant Antibody; scFv Fragment (HPAB-588-FY-S(P)) | ELISA | Human scFv |
| HPAB-591-FY-S(P) | Human Anti-IL6 Recombinant Antibody; scFv Fragment (HPAB-591-FY-S(P)) | ELISA | Human scFv |
| HPAB-0089-WJ-S(P) | Human Anti-IL6 Recombinant Antibody; scFv Fragment (HPAB-0089-WJ-S(P)) | ELISA, WB | Humanized scFv |
| HPAB-1105WJ-S(P) | Mouse Anti-IL6 Recombinant Antibody (clone CLB8); scFv Fragment | Neut, ELISA | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0026CL | Human Anti-IL6 Recombinant Antibody (TAB-0026CL) | Elisa, In vivo, FuncS, Block | Chimeric (mouse/human) IgG |
| TAB-0026CL-F(E) | Human Anti-IL6 Recombinant Antibody; Fab Fragment (TAB-0026CL-F(E)) | Elisa, In vivo, FuncS, Block | Chimeric (mouse/human) Fab |
| TAB-670LC | Anti-human IL6 Recombinant Antibody (NTS) (TAB-670LC) | ELISA, Inhib | Chimeric antibody (mouse/human) |
| TAB-670LC-S(P) | Anti-human IL6 scFv Fragment (NTS) | ELISA | Chimeric antibody (mouse/human) |
| VS3-WK1519 | Human Anti-IL6 Recombinant Antibody (clone CLLB8) | ELISA, FC | Chimeric (mouse/human) IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0171CL | Mouse Anti-IL6 Recombinant Antibody (TAB-0171CL) | ELISA, Block, In vivo | Mouse IgG |
| TAB-0022CL-S(P) | Mouse Anti-IL6 Recombinant Antibody; scFv Fragment (TAB-0022CL-S(P)) | Elisa, In vivo, FuncS, Block | Mouse scFv |
| TAB-669LC-F(E) | Anti-human IL6 Fab Fragment (SK2) | ELISA | |
| TAB-673LC-F(E) | Anti-human IL6 Fab Fragment | ELISA, FC | |
| TAB-679LC-F(E) | Anti-human IL6 Fab Fragment (MH166) | ELISA |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0172CL | Human Anti-IL6 Recombinant Antibody (TAB-0172CL) | ELISA, Block, In vivo | Human IgG |
| TAB-0173CL | Human Anti-IL6 Recombinant Antibody (TAB-0173CL) | ELISA, Block, In vivo | Human IgG1 |
| TAB-0172CL-S(P) | Human Anti-IL6 Recombinant Antibody; scFv Fragment (TAB-0172CL-S(P)) | ELISA, Block, In vivo | Human scFv |
| TAB-0173CL-S(P) | Human Anti-IL6 Recombinant Antibody; scFv Fragment (TAB-0173CL-S(P)) | ELISA, Block, In vivo | Human scFv |
| TAB-678LC-F(E) | Anti-human IL6 Fab Fragment (BA399) | ELISA, FC | Humanized antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0174CL-S(P) | Human Anti-IL6 Recombinant Antibody; scFv Fragment (TAB-0174CL-S(P)) | ELISA, Block, In vivo | Human scFv |
| TAB-0175CL-S(P) | Human Anti-IL6 Recombinant Antibody; scFv Fragment (TAB-0175CL-S(P)) | ELISA, Block, In vivo | Human scFv |
| TAB-0176CL-S(P) | Human Anti-IL6 Recombinant Antibody; scFv Fragment (TAB-0176CL-S(P)) | ELISA, Block, In vivo | Human scFv |
| TAB-0174CL-F(E) | Human Anti-IL6 Recombinant Antibody; Fab Fragment (TAB-0174CL-F(E)) | ELISA, Block, In vivo | Human Fab |
| TAB-0175CL-F(E) | Human Anti-IL6 Recombinant Antibody; Fab Fragment (TAB-0175CL-F(E)) | ELISA, Block, In vivo | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-037LC | Recombinant Anti-Human IL6 Antibody (Fab glycosylation) | ELISA | Humanized antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-197LC | Recombinant Anti-Human IL6 Antibody (Non-glycosylated) | ELISA | Humanized antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0284MZ | Chicken Anti-Interleukin-6 Polyclonal IgY | WB, Indirect ELISA | Chicken antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1471CQ | Mouse Anti-IL6 Recombinant Antibody (clone CBL713) | ICC, ICFC, Neut | Mouse IgG2b |
| NEUT-1472CQ | Mouse Anti-IL6 Recombinant Antibody (clone AS16) | IHC, IP, Neut | Mouse IgG1 |
| NEUT-1473CQ | Rat Anti-Il6 Recombinant Antibody (clone 20F3) | Block, ELISA, IHC-P, IP, Neut, WB | Rat IgG1 |
| NEUT-1475CQ | Rat Anti-Il6 Recombinant Antibody (NEUT-1475CQ) | Neut | Rat IgG2a |
| NEUT-1476CQ | Rat Anti-Il6 Recombinant Antibody (clone CBL112) | Neut, WB | Rat IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1474CQ | Rat Anti-Il6 Recombinant Antibody (clone 32C11) | Block, ELISA, WB | Rat IgG2a |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1814 | Rabbit Anti-IL6 Recombinant Antibody (clone DS1814AB) | WB | Rabbit IgG |
| MOR-4277 | Rabbit Anti-IL6 Recombinant Antibody (clone SI360DS) | ELISA | Rabbit IgG |
| MOR-4622 | Rabbit Anti-IL6 Recombinant Antibody (clone TH135DS) | WB, ELISA | Rabbit IgG |
| MOR-4623 | Rabbit Anti-IL6 Recombinant Antibody (clone TH136DS) | WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-LC3429 | PE-B8/Human IL6 (ILKQKIALD) MHC Tetramer | FCM | |
| MHC-LC3430 | APC-B8/Human IL6 (ILKQKIALD) MHC Tetramer | FCM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NS-043CN | Human Anti-IL6 Recombinant Antibody (NS-043CN) | ELISA, WB | Human IgG1 |
| NS-043CN-F(E) | Human Anti-IL6 Recombinant Antibody; Fab Fragment (NS-043CN-F(E)) | ELISA, WB | Human Fab |
| NS-043CN-S(P) | Human Anti-IL6 Recombinant Antibody; scFv Fragment (NS-043CN-S(P)) | ELISA, WB | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-239 | Afuco™ Anti-IL6 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-239) | FuncS, IF, Neut, ELISA, FC | ADCC enhanced antibody |
| AFC-TAB-097 | Afuco™ Anti-IL6 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-097) | FC, IP, ELISA, Neut, FuncS, IF | ADCC enhanced antibody |
| AFC-TAB-H26 | Afuco™ Anti-IL6 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-H26) | Neut, ELISA, IF, IP, FuncS, FC | ADCC enhanced antibody |
| AFC-TAB-253 | Afuco™ Anti-IL6 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-253) | ELISA, FC, IP, FuncS, IF | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-S0166-YC | Camelid Anti-IL6 Recombinant Single Domain Antibody (HPAB-S0166-YC) | ELISA | Camelid VHH |
| HPAB-S0167-YC | Camelid Anti-IL6 Recombinant Single Domain Antibody (HPAB-S0167-YC) | ELISA | Camelid VHH |
| HPAB-S0168-YC | Camelid Anti-IL6 Recombinant Single Domain Antibody (HPAB-S0168-YC) | ELISA, Inhib | Camelid VHH |
| HPAB-S0169-YC | Camelid Anti-IL6 Recombinant Single Domain Antibody (HPAB-S0169-YC) | ELISA, Inhib | Camelid VHH |
| HPAB-S0170-YC | Camelid Anti-IL6 Recombinant Single Domain Antibody (HPAB-S0170-YC) | ELISA, Inhib | Camelid VHH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-AP702-YC-F(E) | Human Anti-IL6 Recombinant Antibody (clone BA001); Fab Fragment | ELISA, FuncS | Humanized Fab |
| HPAB-AP703-YC-F(E) | Human Anti-IL6 Recombinant Antibody (clone BA436); Fab Fragment | FuncS (Induce) | Humanized Fab |
| HPAB-AP704-YC-F(E) | Human Anti-IL6 Recombinant Antibody (clone BA802); Fab Fragment | FuncS (Induce) | Humanized Fab |
| HPAB-AP705-YC-F(E) | Human Anti-IL6 Recombinant Antibody (clone BA808); Fab Fragment | FuncS (Induce) | Humanized Fab |
| HPAB-AP706-YC-F(E) | Human Anti-IL6 Recombinant Antibody (clone BA840); Fab Fragment | FuncS (Induce) | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0424-XY151 | AbPlus™ Anti-IL6 Magnetic Beads (AS16) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1024-XY279 | Mouse Anti-NHP IL6 Recombinant Antibody (clone 6708) | WB, ELISA | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0225-XY146 | CytoStream™ Mouse Anti-IL6 Recombinant Antibody (VS-0225-XY146) | FC | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-FY11 | Human Anti-IL6 (clone BA001) scFv-Fc Chimera | ELISA, Block | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC526 | Recombinant Anti-IL6 Vesicular Antibody, EV Displayed (VS-0425-YC526) | ELISA, FC, Neut, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY3537 | Anti-Mouse IL6 Immunohistochemistry Kit | IHC | |
| VS-0525-XY3538 | Anti-Human IL6 Immunohistochemistry Kit | IHC |
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