Z-domain of protein A scaffold protein anti-Human IL-6 (CAT#: SZA-L232)

This IL-6 specific binding protein (Z-domain of protein A) was investigated by an α-helix shuffling strategy. The primary scaffold protein was from a naive combinatorial library of the three-helix bundle Z domain derived from staphylococcal protein A. A hierarchical library was constructed through selective re-randomization of six amino acid positions in one of the two α-helices of the domain, making up the Taq DNA polymerase binding surface. After selections using monovalent phage display technology, second generation variants were identified having affinities (KD=500 pM) for IL-6 as determined by biosensor technology. It's potential to be used in diagnostic, research and therapeutic applications.


Specific Inquiry
  • Size:
  • Conjugation:
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Subcellular Location
Normal Tissue
RNA Expression

Specifications

  • Scaffold Name
  • Z-domain of protein A
  • Origin
  • Staphylococcal protein A
  • Core Structure
  • 3-α helixes
  • Variable Regions
  • 13 Residues on first and second helix surface
  • Target
  • IL-6
  • Species Reactivity
  • Human
  • Expression Host
  • E. coli
  • Affinity Constant
  • 500 pM
  • Applications
  • ELISA; IHC; Microscopy; FC; WB; FuncS

Target

  • Alternative Names
  • Staphylococcal protein A; Z-domain of protein A; CDF; HGF; HSF; BSF2; IL-6; BSF-2; IFNB2; IFN-beta-2

Related Resources

  • Related Diseases
  • Related Signaling Pathways

Downloads

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See other products for "IL6"

Humanized Antibody

CAT Product Name Application Type
TAB-253 Anti-Human IL-6 Recombinant Antibody (Olokizumab) WB, ELISA, FC, IP, FuncS, IF, Neut IgG4 - kappa
TAB-0172CL Human Anti-IL6 Recombinant Antibody (TAB-0172CL) ELISA, Block, In vivo Human IgG
TAB-0173CL Human Anti-IL6 Recombinant Antibody (TAB-0173CL) ELISA, Block, In vivo Human IgG1
TAB-678LC Anti-human IL6 Recombinant Antibody (BA399) (TAB-678LC) ELISA, FC, Inhib Humanized antibody
TAB-678LC-S(P) Anti-human IL6 scFv Fragment (BA399) ELISA, FC Humanized antibody

Chimeric Antibody

CAT Product Name Application Type
TAB-0026CL-S(P) Mouse Anti-IL6 Recombinant Antibody; scFv Fragment (TAB-0026CL-S(P)) Elisa, In vivo, FuncS, Block Mouse scFv
TAB-0026CL-F(E) Human Anti-IL6 Recombinant Antibody; Fab Fragment (TAB-0026CL-F(E)) Elisa, In vivo, FuncS, Block Chimeric (mouse/human) Fab
TAB-670LC Anti-human IL6 Recombinant Antibody (NTS) (TAB-670LC) ELISA, Inhib Chimeric antibody (mouse/human)
TAB-670LC-S(P) Anti-human IL6 scFv Fragment (NTS) ELISA Chimeric antibody (mouse/human)
TAB-670LC-F(E) Anti-human IL6 Fab Fragment (NTS) ELISA Chimeric antibody (mouse/human)

Fab Glycosylation

CAT Product Name Application Type
Gly-037LC Recombinant Anti-Human IL6 Antibody (Fab glycosylation) ELISA Humanized antibody

Deglycosylated Antibody (Non-glycosylated IgGs)

CAT Product Name Application Type
Gly-197LC Recombinant Anti-Human IL6 Antibody (Non-glycosylated) ELISA Humanized antibody

Chicken IgY Antibody

CAT Product Name Application Type
BRD-0284MZ Chicken Anti-Interleukin-6 Polyclonal IgY WB, Indirect ELISA Chicken antibody

Blocking Antibody

CAT Product Name Application Type
NEUT-1474CQ Rat Anti-Il6 Recombinant Antibody (clone 32C11) Block, ELISA, WB Rat IgG2a

MHC Tetramer for Cancer

ADCC Enhanced Antibody

CAT Product Name Application Type
AFC-TAB-239 Afuco™ Anti-IL6 ADCC Recombinant Antibody (Elsilimomab), ADCC Enhanced FuncS, IF, Neut, ELISA, FC ADCC enhanced antibody
AFC-TAB-097 Afuco™ Anti-IL6 ADCC Recombinant Antibody (Sirukumab), ADCC Enhanced FC, IP, ELISA, Neut, FuncS, IF ADCC enhanced antibody
AFC-TAB-H26 Afuco™ Anti-IL6 ADCC Recombinant Antibody (Enlimomab), ADCC Enhanced Neut, ELISA, IF, IP, FuncS, FC ADCC enhanced antibody
AFC-TAB-253 Afuco™ Anti-IL6 ADCC Recombinant Antibody (Olokizumab), ADCC Enhanced ELISA, FC, IP, FuncS, IF ADCC enhanced antibody

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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