This IL-6 specific binding protein (Z-domain of protein A) was investigated by an α-helix shuffling strategy. The primary scaffold protein was from a naive combinatorial library of the three-helix bundle Z domain derived from staphylococcal protein A. A hierarchical library was constructed through selective re-randomization of six amino acid positions in one of the two α-helices of the domain, making up the Taq DNA polymerase binding surface. After selections using monovalent phage display technology, second generation variants were identified having affinities (KD=500 pM) for IL-6 as determined by biosensor technology. It's potential to be used in diagnostic, research and therapeutic applications.
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CAT | Product Name | Application | Type |
---|---|---|---|
TAB-239 | Anti-Human IL6 Recombinant Antibody (Elsilimomab) | WB, FuncS, IF, Neut, ELISA, FC, IP | IgG1 |
TAB-0171CL-S(P) | Mouse Anti-IL6 Recombinant Antibody; scFv Fragment (TAB-0171CL-S(P)) | ELISA, Block, In vivo | Mouse scFv |
TAB-0171CL-F(E) | Mouse Anti-IL6 Recombinant Antibody; Fab Fragment (TAB-0171CL-F(E)) | ELISA, Block, In vivo | Mouse Fab |
TAB-673LC-F(E) | Anti-human IL6 Fab Fragment | ELISA, FC | |
TAB-679LC-F(E) | Anti-human IL6 Fab Fragment (MH166) | ELISA |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-253 | Anti-Human IL-6 Recombinant Antibody (Olokizumab) | WB, ELISA, FC, IP, FuncS, IF, Neut | IgG4 - kappa |
TAB-0172CL | Human Anti-IL6 Recombinant Antibody (TAB-0172CL) | ELISA, Block, In vivo | Human IgG |
TAB-0173CL | Human Anti-IL6 Recombinant Antibody (TAB-0173CL) | ELISA, Block, In vivo | Human IgG1 |
TAB-678LC | Anti-human IL6 Recombinant Antibody (BA399) (TAB-678LC) | ELISA, FC, Inhib | Humanized antibody |
TAB-678LC-S(P) | Anti-human IL6 scFv Fragment (BA399) | ELISA, FC | Humanized antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
MOB-0249MC | Rabbit Anti-IL6 Antibody | WB, ELISA | |
PABL-244 | Human Anti-IL6 Recombinant Antibody (clone YC136) | WB, Block, FuncS | Human IgG |
PABC-232 | Camelid Anti-IL6 Recombinant Antibody (PABC-232) | ELISA | Camelid IgG |
HPAB-AP702-YC | Human Anti-IL6 Recombinant Antibody (clone BA001) | ELISA, FuncS | Humanized IgG |
HPAB-AP703-YC | Human Anti-IL6 Recombinant Antibody (clone BA436) | FuncS (Induce) | Humanized IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-0026CL-S(P) | Mouse Anti-IL6 Recombinant Antibody; scFv Fragment (TAB-0026CL-S(P)) | Elisa, In vivo, FuncS, Block | Mouse scFv |
TAB-0026CL-F(E) | Human Anti-IL6 Recombinant Antibody; Fab Fragment (TAB-0026CL-F(E)) | Elisa, In vivo, FuncS, Block | Chimeric (mouse/human) Fab |
TAB-670LC | Anti-human IL6 Recombinant Antibody (NTS) (TAB-670LC) | ELISA, Inhib | Chimeric antibody (mouse/human) |
TAB-670LC-S(P) | Anti-human IL6 scFv Fragment (NTS) | ELISA | Chimeric antibody (mouse/human) |
TAB-670LC-F(E) | Anti-human IL6 Fab Fragment (NTS) | ELISA | Chimeric antibody (mouse/human) |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-681LC-S(P) | Human Anti-IL6 Recombinant Antibody; scFv Fragment (TAB-681LC-S(P)) | ELISA | Human scFv |
TAB-680LC-F(E) | Human Anti-IL6 Recombinant Antibody; Fab Fragment (TAB-680LC-F(E)) | ELISA | Human Fab |
TAB-681LC-F(E) | Human Anti-IL6 Recombinant Antibody; Fab Fragment (TAB-681LC-F(E)) | ELISA | Human Fab |
TAB-682LC-F(E) | Human Anti-IL6 Recombinant Antibody; Fab Fragment (TAB-682LC-F(E)) | ELISA | Human Fab |
TAB-683LC-F(E) | Anti-human IL6 Fab Fragment (IL6gk3-2) | ELISA | Human antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
Gly-037LC | Recombinant Anti-Human IL6 Antibody (Fab glycosylation) | ELISA | Humanized antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
Gly-197LC | Recombinant Anti-Human IL6 Antibody (Non-glycosylated) | ELISA | Humanized antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
BRD-0284MZ | Chicken Anti-Interleukin-6 Polyclonal IgY | WB, Indirect ELISA | Chicken antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-1450CQ | Mouse Anti-IL6 Recombinant Antibody (clone CBL596) | Neut | Mouse IgG2a |
NEUT-1451CQ | Mouse Anti-IL6 Recombinant Antibody (clone CBL661) | Neut | Mouse IgG2b |
NEUT-1482CQ | Rat Anti-Il6 Recombinant Antibody (clone 5A37) | Neut, WB | Rat IgG1 |
NEUT-1483CQ | Rat Anti-Il6 Recombinant Antibody (clone mAb0847) | FC, IHC-Fr, IP, Neut | Rat IgG1 |
NEUT-1484CQ | Rat Anti-Il6 Recombinant Antibody (clone MP5-20F3) | ELISA, CyTOF, ELISPOT, Neut, IHC | Rat IgG1, κ |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-1474CQ | Rat Anti-Il6 Recombinant Antibody (clone 32C11) | Block, ELISA, WB | Rat IgG2a |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-1814 | Rabbit Anti-IL6 Recombinant Antibody (clone DS1814AB) | WB | Rabbit IgG |
MOR-4277 | Rabbit Anti-IL6 Recombinant Antibody (clone SI360DS) | ELISA | Rabbit IgG |
MOR-4622 | Rabbit Anti-IL6 Recombinant Antibody (clone TH135DS) | WB, ELISA | Rabbit IgG |
MOR-4623 | Rabbit Anti-IL6 Recombinant Antibody (clone TH136DS) | WB | Rabbit IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
MHC-LC3429 | PE-B8/Human IL6 (ILKQKIALD) MHC Tetramer | FCM | |
MHC-LC3430 | APC-B8/Human IL6 (ILKQKIALD) MHC Tetramer | FCM |
CAT | Product Name | Application | Type |
---|---|---|---|
NS-043CN | Human Anti-IL6 Recombinant Antibody (NS-043CN) | ELISA, WB | Human IgG1 |
NS-043CN-F(E) | Human Anti-IL6 Recombinant Antibody; Fab Fragment (NS-043CN-F(E)) | ELISA, WB | Human Fab |
NS-043CN-S(P) | Human Anti-IL6 Recombinant Antibody; scFv Fragment (NS-043CN-S(P)) | ELISA, WB | Human scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0030LY-S(P) | Humanized Anti-IL6 Recombinant Antibody; scFv Fragment (HPAB-0030LY-S(P)) | WB | scFv |
HPAB-1562-FY-F(E) | Human Anti-IL6 Recombinant Antibody; Fab Fragment (HPAB-1562-FY-F(E)) | WB, ELISA, Neut | Humanized Fab |
HPAB-1563-FY-F(E) | Human Anti-IL6 Recombinant Antibody; Fab Fragment (HPAB-1563-FY-F(E)) | WB, ELISA, Neut | Humanized Fab |
HPAB-1564-FY-F(E) | Human Anti-IL6 Recombinant Antibody; Fab Fragment (HPAB-1564-FY-F(E)) | WB, ELISA, Neut | Humanized Fab |
HPAB-1105WJ-S(P) | Mouse Anti-IL6 Recombinant Antibody (clone CLB8); scFv Fragment | Neut, ELISA | Mouse scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-588-FY-F(E) | Human Anti-IL6 Recombinant Antibody; Fab Fragment (HPAB-588-FY-F(E)) | ELISA | Human Fab |
HPAB-591-FY-F(E) | Human Anti-IL6 Recombinant Antibody; Fab Fragment (HPAB-591-FY-F(E)) | ELISA | Human Fab |
HPAB-0876-FY-S(P) | Human Anti-IL6 Recombinant Antibody; scFv Fragment (HPAB-0876-FY-S(P)) | ELISA | Human scFv |
HPAB-0877-FY-S(P) | Human Anti-IL6 Recombinant Antibody; scFv Fragment (HPAB-0877-FY-S(P)) | ELISA | Human scFv |
HPAB-0089-WJ-F(E) | Human Anti-IL6 Recombinant Antibody; Fab Fragment (HPAB-0089-WJ-F(E)) | ELISA, WB | Humanized Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
AFC-TAB-239 | Afuco™ Anti-IL6 ADCC Recombinant Antibody (Elsilimomab), ADCC Enhanced | FuncS, IF, Neut, ELISA, FC | ADCC enhanced antibody |
AFC-TAB-097 | Afuco™ Anti-IL6 ADCC Recombinant Antibody (Sirukumab), ADCC Enhanced | FC, IP, ELISA, Neut, FuncS, IF | ADCC enhanced antibody |
AFC-TAB-H26 | Afuco™ Anti-IL6 ADCC Recombinant Antibody (Enlimomab), ADCC Enhanced | Neut, ELISA, IF, IP, FuncS, FC | ADCC enhanced antibody |
AFC-TAB-253 | Afuco™ Anti-IL6 ADCC Recombinant Antibody (Olokizumab), ADCC Enhanced | ELISA, FC, IP, FuncS, IF | ADCC enhanced antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-S0166-YC | Camelid Anti-IL6 Recombinant Single Domain Antibody (clone 6D5) | ELISA | Camelid VHH |
HPAB-S0167-YC | Camelid Anti-IL6 Recombinant Single Domain Antibody (clone 8F2) | ELISA | Camelid VHH |
HPAB-S0168-YC | Camelid Anti-IL6 Recombinant Single Domain Antibody (clone 6B12) | ELISA, Inhib | Camelid VHH |
HPAB-S0169-YC | Camelid Anti-IL6 Recombinant Single Domain Antibody (clone 7G4) | ELISA, Inhib | Camelid VHH |
HPAB-S0170-YC | Camelid Anti-IL6 Recombinant Single Domain Antibody (clone 7G5) | ELISA, Inhib | Camelid VHH |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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