Anti-FRα-DGN462 ADC (CAT#: ADC-120LZY)

• Antibody Overview
• Anti-FRαSeriMab (SeriMab:N-terminal serine engineered Antibody)

• Antibody Conjugation
• site-specific conjugation platform employs N-terminal serine engineered antibodies (SeriMabs), using ligation chemistry orthogonal to lysine and cysteine modification which typically employs maleimide containing linkers

• Linker
• maleimide containing linkers

• Drug
• DGN462

• Drug Class/Description
• Class: DGN462
  Description: DGN462,the mono-imine IGN, highly potent cytotoxic DNA alkylateing agent.DGN462 formed covalent DNA adducts through alkylation of the C2-amino group of guanine.

• Introduction
• The protein encoded by this gene is a member of the folate receptor family. Members of this gene family bind folic acid and its reduced derivatives, and transport 5-methyltetrahydrofolate into cells. This gene product is a secreted protein that either anchors to membranes via a glycosyl-phosphatidylinositol linkage or exists in a soluble form. Mutations in this gene have been associated with neurodegeneration due to cerebral folate transport deficiency. Due to the presence of two promoters, multiple transcription start sites, and alternative splicing, multiple transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Oct 2009]

• Alternative Names
• FOLR1; folate receptor 1 (adult); FBP; FOLR; folate receptor alpha; FR-alpha; KB cells FBP; folate binding protein; folate receptor, adult; adult folate-binding protein; ovarian tumor-associated antigen MOv18;

• Gene ID
• 2348

• UniProt ID
• A0A024R5H1

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