Rabbit Anti-APC Recombinant Antibody (VS3-CJ816) (CAT#: VS3-CJ816)
This product is a rabbit antibody that recognizes human, and rat APC.
Specific Inquiry
Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line RH-30
(Immunofluorescent staining of human cell line RH-30 shows localization to plasma membrane & the Golgi apparatus.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/13362/1401_C6_5_selected.jpg
(Immunofluorescent staining of human cell line RH-30 shows localization to plasma membrane & the Golgi apparatus.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/13362/1401_C6_5_selected.jpg
Figure 2 IHC staining of human cerebral cortex
(Immunohistochemical staining of human cerebral cortex shows strong positivity in neuropil.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/13349/165147_B_9_5_selected.jpg
(Immunohistochemical staining of human cerebral cortex shows strong positivity in neuropil.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/13349/165147_B_9_5_selected.jpg
Figure 3 Cerebral cortex
(Neuropil
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/13349/165147_B_9_5.jpg
(Neuropil
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/13349/165147_B_9_5.jpg
Figure 4 Colon
(Glandular cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/13349/165147_A_9_3.jpg
(Glandular cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/13349/165147_A_9_3.jpg
Figure 5 Liver
(Cholangiocytes
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Hepatocytes
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/13349/165147_A_7_4.jpg
(Cholangiocytes
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Hepatocytes
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/13349/165147_A_7_4.jpg
Figure 6 Kidney
(Collecting ducts
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Distal tubules
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Proximal tubules (cell body)
Staining: High
Intensity: Strong
Quantity:>75%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/13349/165147_A_7_5.jpg
(Collecting ducts
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Distal tubules
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Proximal tubules (cell body)
Staining: High
Intensity: Strong
Quantity:>75%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/13349/165147_A_7_5.jpg
Figure 7 Testis
(Leydig cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/13349/165147_A_6_6.jpg
(Leydig cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/13349/165147_A_6_6.jpg
Figure 8 RNA cell line category: Low cell line specificity
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000134982-APC
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000134982-APC
Specifications
- Immunogen
- Recombinant protein
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human, Rat APC
- Species Reactivity
- Human, Rat
- Applications
- WB, ICC, IP
- Conjugate
- Unconjugated
Product Property
- Purification
- Protein A affinity purified
- Purity
- >95% as determined by SDS-PAGE
- Format
- Liquid
- Buffer
- 40% Glycerol, 1% BSA, TBS, pH7.4.
- Preservative
- 0.05% Sodium Azide
- Storage
- Store at 4°C for short term. Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- This antibody has been tested for use in Western Blot, Immunocytochemistry, Immunoprecipitation.
Target
- Alternative Names
- GS; DP2; DP3; BTPS2; DESMD; DP2.5; PPP1R46
- Gene ID
- 324
- UniProt ID
- P25054
- Sequence Similarities
- Belongs to the adenomatous polyposis coli (APC) family.
- Cellular Localization
- Cell junction, Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Membrane, Microtubule
- Post Translation Modifications
- Phosphorylated by GSK3B.
Ubiquitinated, leading to its degradation by the proteasome. Ubiquitination is facilitated by Axin. Deubiquitinated by ZRANB1/TRABID.
- Protein Refseq
- NP_000029.2; NP_001120982.1; NP_001120983.2
- Function
- Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization.
Recommended Products
Isotype Control
Secondary Antibody
Related Resources
Breast Cancer
Colorectal Cancer
Endometrial Cancer
Gastric Cancer
Pancreatic Cancer
Prostate Cancer
Throid Cancer
Hepatocellular Carcinoma
Cushing Syndrome
Canonical Wnt Signaling Pathway
JAK-STAT Signaling Pathway
Non-Canonical Wnt Signaling Pathway
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "APC"
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-72 | Recombinant Anti-human APC Antibody | ELISA, WB, FC, FuncS | IgG |
| MRO-0106-CN | Rabbit Anti-APC Recombinant Antibody (clone CBACN-035) | WB, IF, IP | Rabbit IgG |
| MRO-1651-CN | Rabbit Anti-APC Polyclonal Antibody (MRO-1651-CN) | WB, IF, IHC, FC | Rabbit IgG |
| ZG-0545J | Rabbit Anti-APC Recombinant Antibody (clone 5F2) | ELISA, WB, IHC | Rabbit IgG |
| VS3-XY79 | Mouse Anti-APC Recombinant Antibody (clone 1F7G2) | FC | Mouse IgG1 |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-72-S(P) | Recombinant Anti-human APC Antibody scFv Fragment | IP, IF, Biosensors, FuncS | scFv |
| MHH-72-S(P) | Recombinant Human Anti-human APC Antibody scFv Fragment | ELISA, WB, FC, FuncS | scFv |
| HPAB-0095-WJ-S(P) | Human Anti-APC Recombinant Antibody; scFv Fragment (HPAB-0095-WJ-S(P)) | ELISA | Humanized scFv |
| HPAB-J0036-YC-S(P) | Mouse Anti-aPC Recombinant Antibody; scFv Fragment (HPAB-J0036-YC-S(P)) | ELISA | Mouse scFv |
| HPAB-J0037-YC-S(P) | Mouse Anti-aPC Recombinant Antibody; scFv Fragment (HPAB-J0037-YC-S(P)) | ELISA | Mouse scFv |
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-241CT-F(E) | Mouse Anti-aPC Recombinant Antibody; Fab Fragment (TAB-241CT-F(E)) | Non-neutralizing | Mouse Fab |
| TAB-242CT-F(E) | Human Anti-aPC Recombinant Antibody; Fab Fragment (TAB-242CT-F(E)) | ELISA, WB | Human Fab |
| TAB-243CT-F(E) | Human Anti-aPC Recombinant Antibody; Fab Fragment (TAB-243CT-F(E)) | ELISA, WB | Human Fab |
| TAB-244CT-F(E) | Human Anti-aPC Recombinant Antibody; Fab Fragment (TAB-244CT-F(E)) | ELISA, WB | Human Fab |
| TAB-245CT-F(E) | Human Anti-aPC Recombinant Antibody; Fab Fragment (TAB-245CT-F(E)) | ELISA, WB | Human Fab |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0199 | Hi-Affi™ Rabbit Anti-APC Recombinant Antibody (clone DS199AB) | WB, IHC, ICC | Rabbit IgG |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0095-WJ-F(E) | Human Anti-APC Recombinant Antibody; Fab Fragment (HPAB-0095-WJ-F(E)) | ELISA | Humanized Fab |
| HPAB-J0036-YC-F(E) | Mouse Anti-aPC Recombinant Antibody; Fab Fragment (HPAB-J0036-YC-F(E)) | ELISA | Mouse Fab |
| HPAB-J0037-YC-F(E) | Mouse Anti-aPC Recombinant Antibody; Fab Fragment (HPAB-J0037-YC-F(E)) | ELISA | Mouse Fab |
| HPAB-J0038-YC-F(E) | Mouse Anti-aPC Recombinant Antibody; Fab Fragment (HPAB-J0038-YC-F(E)) | ELISA | Mouse Fab |
| HPAB-J0039-YC-F(E) | Mouse Anti-aPC Recombinant Antibody; Fab Fragment (HPAB-J0039-YC-F(E)) | ELISA | Mouse Fab |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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