Human Anti-CD37 Recombinant Antibody (clone B2)
CAT#: HPAB-AP034-YC
This is a human antibody binding to CD37. The use of CD37 antibodies, specifically A2 and B2, in combination with ICE, unexpectedly leads to an enhanced anti-tumor effect.
Published Data
Gene Expression
Whole Blood Assay
Figure 1 Whole Blood Assay: Effect of Antibodies A2 and B2 ON Viable CLL Cells.
Whole blood samples from CLL patients were incubated with increasing concentrations (0.001 μg/ml to 100 μg/ml) of antibodies A2 and B2 for 3 hours. The percentage of viable CLL cells at the end of the incubation period in relation to antibody concentration is depicted, curves represent mean of 11 individual patient samples. Standard deviation for each concentration tested is indicated. A2: filled triangle; B2: open triangle. Dotted line represents activity of an isotype matched control antibody.
Whole Blood Assay
Figure 2 Whole Blood Assay with CLL Patient Samples: Comparison of Different Antibodies.
Blood samples were incubated with 10 μg/ml of antibodies A2, B2, rituximab, alemtuzumab and an isotype matched control antibody for 3 hours. The percentage of viable CLL cells at the end of the incubation period is depicted, bars represent mean of 11 patient samples. Standard deviation is indicated. Dotted line represents activity of the isotype matched control antibody.
Whole Blood Assay
Figure 3 Whole Blood Assay with CLL Patient Samples: Comparison of Different Patient Subgroups.
Blood samples are incubated with 10 μg/ml of antibodies A2, B2, rituximab and alemtuzumab for 3 hours. The percentage of viable CLL cells at the end of the incubation period for different patient subgroups is depicted, bars represent mean of the indicated number of patient samples. Standard deviation is indicated.
Whole Blood Assay
Figure 4 Whole Blood Assay with CLL Patient Samples: Comparison of Different Patient Subgroups.
Blood samples from normal risk patients (n=11) and high risk patients (n=10) were incubated with 10 μg/ml of antibodies A2, B2, rituximab and alemtuzumab for 8 hours. The percentage of viable CLL cells at the end of the incubation period for the two patient subgroups is depicted, bars represent mean values, standard deviation is indicated.
Figure 5 Binding to FCγ-Receptor 3A
The affinity of antibodies A2 and B2 to Fcγ-receptor 3a is determined by surface plasmon resonance analysis (SFP).
❮
❯
Subcellular Location
Figure 1 IF staining of human cell line HEL
Immunofluorescent staining of human cell line HEL shows localization to plasma membrane & the Golgi apparatus.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/32120/1848_F10_26_cr5abb8def07051_selected.jpg
Normal Tissue
Figure 2 Tonsil
High expression
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/32120/116092_A_5_8_val_selected.jpg
Normal Tissue
Figure 3 Colon
Enterocytes - Mucosal lymphoid cells Staining: Medium Intensity: Strong
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2492/6132_A_9_3.jpg
Normal Tissue
Figure 4 Lymph node
Germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2492/6132_A_7_8.jpg
Normal Tissue
Figure 5 Spleen
Cells in white pulp Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/32120/116092_B_8_4.jpg
RNA Expression
Figure 6 RNA cell line category: Cell line enhanced (Daudi, HMC-1, RPMI-8226, THP-1, U-698, U-937)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000104894-CD37
❮
❯
Specifications
- Host Species
- Human
- Type
- Human IgG
- Specificity
- Human CD37
- Species Reactivity
- Human
- Clone
- B2
- Applications
- FuncS
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- The antibody was validated for Function Assay. For details, refer to Published Data.
Target
REVIEWS AND Q&AS
CITATIONS
RESOURCES
DOWNLOADS
RELATED PRODUCTS
Inquiry
Navs
Customer Review
There are currently no Customer reviews or questions for HPAB-AP034-YC. Click the button above to contact us or submit your feedback about this product.
Submit Your Publication
Published with our product? Submit your paper and receive a 10% discount on your next order! Share your research to earn exclusive rewards.
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "Clone B2"
- CAT
- Product Name
See other products for "CD37"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1367z | Mouse Anti-CD37 Recombinant Antibody (clone 41C4) | WB, IP, IF, IHC, ELISA | Mouse IgG2b, κ |
| HPAB-AP033-YC | Human Anti-CD37 Recombinant Antibody (clone A2) | FuncS | Human IgG |
| HPAB-0901-WJ | Mouse Anti-CD37 Recombinant Antibody (HPAB-0901-WJ) | FC | Human IgG |
| ZG-0384F | Mouse Anti-CD37 Recombinant Antibody (ZG-0384F) | IF, ELISA | Mouse IgG |
| VS-0723-WK238 | Rabbit Anti-CD37 Recombinant Antibody (VS-0723-WK238) | ELISA, FC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-904 | Anti-Human CD37 Recombinant Antibody (Otlertuzumab) | ELISA, IP, FC, FuncS, Neut, IF, ICC | VH - V-kappa - CH2 - CH3 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0272CL | Human Anti-CD37 Recombinant Antibody (TAB-0272CL) | ELISA, WB | Chimeric (mouse/human) |
| TAB-0273CL | Human Anti-CD37 Recombinant Antibody (TAB-0273CL) | Block | Chimeric (mouse/human) |
| TAB-0272CL-S(P) | Human Anti-CD37 Recombinant Antibody scFv Fragment (TAB-0272CL-S(P)) | ELISA, WB | Chimeric (mouse/human) |
| TAB-0273CL-S(P) | Human Anti-CD37 Recombinant Antibody scFv Fragment (TAB-0273CL-S(P)) | Block | Chimeric (mouse/human) |
| TAB-0272CL-F(E) | Human Anti-CD37 Recombinant Antibody Fab Fragment (TAB-0272CL-F(E)) | ELISA, WB | Chimeric (mouse/human) |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-467CQ | Anti-Human CD37 Recombinant Antibody (Lilotomab) | ELISA, IHC, FC, IP, IF, FuncS | IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0159-FY-S(P) | Mouse Anti-CD37 Recombinant Antibody; scFv Fragment (HPAB-0159-FY-S(P)) | Activ, Depletion, FuncS, Inhib | Mouse scFv |
| HPAB-0163-FY-S(P) | Mouse Anti-CD37 Recombinant Antibody; scFv Fragment (HPAB-0163-FY-S(P)) | FC, Inhib | Mouse scFv |
| HPAB-0164-FY-S(P) | Mouse Anti-CD37 Recombinant Antibody; scFv Fragment (HPAB-0164-FY-S(P)) | FC, Inhib | Mouse scFv |
| HPAB-AP033-YC-S(P) | Human Anti-CD37 Recombinant Antibody (clone A2); scFv Fragment | FuncS | Human scFv |
| HPAB-0901-WJ-S(P) | Mouse Anti-CD37 Recombinant Antibody scFv Fragment (HPAB-0901-WJ-S(P)) | FC | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0159-FY-F(E) | Mouse Anti-CD37 Recombinant Antibody; Fab Fragment (HPAB-0159-FY-F(E)) | Activ, Depletion, FuncS, Inhib | Mouse Fab |
| HPAB-0163-FY-F(E) | Mouse Anti-CD37 Recombinant Antibody; Fab Fragment (HPAB-0163-FY-F(E)) | FC, Inhib | Mouse Fab |
| HPAB-0164-FY-F(E) | Mouse Anti-CD37 Recombinant Antibody; Fab Fragment (HPAB-0164-FY-F(E)) | FC, Inhib | Mouse Fab |
| HPAB-AP033-YC-F(E) | Human Anti-CD37 Recombinant Antibody (clone A2); Fab Fragment | FuncS | Human Fab |
| HPAB-AP034-YC-F(E) | Human Anti-CD37 Recombinant Antibody (clone B2); Fab Fragment | FuncS | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-467CQ | Afuco™ Anti-CD37 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-467CQ) | ELISA, IHC, FC, IP, IF, FuncS | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0924-YC112 | Mouse Anti-CD37 Recombinant Antibody Hexamer (VS-0924-YC112), CDC Enhanced | FC, Inhib, CDC | Antibody hexamer |
| VS-0924-YC113 | Human Anti-CD37 Recombinant Antibody Hexamer (VS-0924-YC113), CDC Enhanced | CDC | Antibody hexamer |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0125-FY21 | Human Anti-CD37 (clone chHH1.1) scFv-Fc Chimera | Inhib | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0225-XY43 | CytoStream™ Mouse Anti-CD37 Recombinant Antibody (VS-0225-XY43) | FC | Mouse IgG1, kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC73 | Recombinant Anti-CD37 Vesicular Antibody, EV Displayed (VS-0425-YC73) | ELISA, FC, Neut, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-YC9 | Recombinant Anti-CD37 Biparatopic Antibody, Asymmetric hetero Fab | ELISA | Asymmetric hetero Fab |
Specific Inquiry
Add to compare
See Our Custom Production in Action
Popular Products
Application: WB, FC, IP, ELISA, Neut, FuncS, IF
Application: WB, ELISA, IP, FC, FuncS, Neut, IF
Application: Neut, ELISA, IF, IP, FuncS, FC, ICC
Application: IF, IP, Neut, FuncS, ELISA, FC, ICC
Application: WB, ELISA, IF, FuncS, Apop, BA
Application: ELISA, FuncS
Application: Neut, ELISA, WB, SPR, IF, EM
Application: WB, IHC-Fr, IHC-P, ICC, IF
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
