Mouse Anti-CD70 Recombinant Antibody Hexamer (VS-0924-YC124), CDC Enhanced
CAT#: VS-0924-YC124
The product is a mouse anti-CD70 antibody hexamer with enhanced CDC activity. This hexameric IgG1 targets both human and mouse CD70 and includes specific mutations that enhance hexamerization. This promotes optimal C1q binding and significantly boosts complement-dependent cytotoxicity (CDC).
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line SiHa
Immunofluorescent staining of human cell line SiHa shows localization to nucleoplasm.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/46582/1486_B2_3_selected.jpg
Subcellular Location and Protein Expression
Figure 2 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/46582/1559_D6_2_red_green.jpg
RNA Expression
Figure 3 RNA cell line category: Cell line enhanced (SiHa, THP-1, U-251 MG, U-266/70, U-266/84, U-698)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000125726-CD70
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Specifications
- Host Species
- Mouse
- Type
- Antibody hexamer
- Specificity
- Human and Mouse CD70
- Species Reactivity
- Human, Mouse
- Molecule Class
- ~ 900 kDa
- Applications
- FC, ADCC, CDC
- Conjugate
- None
- Related Disease
- Cancer
Product Property
- Clonality
- Monoclonal
- Purification
- Protein G purified
- Purity
- >95% determined as SDS-PAGE and SEC-HPLC
- Aggregation
- <5%
- Buffer
- PBS, pH 7.4
- Preservative
- No preservatives
- Storage
- Store at 4°C short term (1-2 weeks). Store at -20°C long term (12 months). Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- CD70 Molecule; Tumor Necrosis Factor Ligand Superfamily Member 7; CD70 Antigen; CD27 Ligand; CD27LG; TNFSF7; CD27-L
- Gene ID
- 970
- UniProt ID
- P32970
- Long Name
- CD70 Molecule
- Sequence Similarities
- Belongs to the tumor necrosis factor family.
- Cellular Localization
- Cell membrane; Single-pass type II membrane protein
- Post Translation Modifications
- N-glycosylated. ( P32970-CD70_HUMAN )
Glycosylation at Asn63, Tyr74, and Asn170 ( NX_P32970 [NX_P32970-1] )
- Function
- Expressed at the plasma membrane of B cells, it is the ligand of the CD27 receptor which is specifically expressed at the surface of T cells (PubMed:28011863, 28011864, 8387892).
The CD70-CD27 signaling pathway mediates antigen-specific T cell activation and expansion which in turn provides immune surveillance of B cells (PubMed:28011863, 28011864). CD70_HUMAN,P32970
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COA
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