Mouse Anti-CD70 Recombinant Antibody Hexamer (VS-0924-YC124), CDC Enhanced

Name: Mouse Anti-CD70 Recombinant Antibody Hexamer (VS-0924-YC124), CDC Enhanced
SKU: VS-0924-YC124
Rating: 5 (1 reviews)

CAT#: VS-0924-YC124

The product is a mouse anti-CD70 antibody hexamer with enhanced CDC activity. This hexameric IgG1 targets both human and mouse CD70 and includes specific mutations that enhance hexamerization. This promotes optimal C1q binding and significantly boosts complement-dependent cytotoxicity (CDC).

Gene Expression

Subcellular Location and Protein Expression Figure 1 IF staining of human cell line SiHa

Immunofluorescent staining of human cell line SiHa shows localization to nucleoplasm.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/46582/1486_B2_3_selected.jpg

Subcellular Location and Protein Expression Figure 2 IF staining of human cell line U-251 MG

Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/46582/1559_D6_2_red_green.jpg

RNA Expression Figure 3 RNA cell line category: Cell line enhanced (SiHa, THP-1, U-251 MG, U-266/70, U-266/84, U-698)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000125726-CD70

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Specifications

Host Species
Mouse

Type
Antibody hexamer

Specificity
Human and Mouse CD70

Species Reactivity
Human, Mouse

Molecule Class
~ 900 kDa

Applications
FC, ADCC, CDC

Conjugate
None

Related Disease
Cancer

Product Property

Clonality
Monoclonal

Purification
Protein G purified

Purity
>95% determined as SDS-PAGE and SEC-HPLC

Aggregation
<5%

Buffer
PBS, pH 7.4

Preservative
No preservatives

Storage
Store at 4°C short term (1-2 weeks). Store at -20°C long term (12 months). Avoid repeated freeze/thaw cycles.

Target

Alternative Names
CD70 Molecule; Tumor Necrosis Factor Ligand Superfamily Member 7; CD70 Antigen; CD27 Ligand; CD27LG; TNFSF7; CD27-L

Gene ID
970

UniProt ID
P32970

Long Name
CD70 Molecule

Sequence Similarities
Belongs to the tumor necrosis factor family.

Cellular Localization
Cell membrane; Single-pass type II membrane protein

Post Translation Modifications
N-glycosylated. ( P32970-CD70_HUMAN )
Glycosylation at Asn63, Tyr74, and Asn170 ( NX_P32970 [NX_P32970-1] )

Function
Expressed at the plasma membrane of B cells, it is the ligand of the CD27 receptor which is specifically expressed at the surface of T cells (PubMed:28011863, 28011864, 8387892).
The CD70-CD27 signaling pathway mediates antigen-specific T cell activation and expansion which in turn provides immune surveillance of B cells (PubMed:28011863, 28011864). CD70_HUMAN,P32970

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Downloadable Resources

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Datasheet

Datasheet - VS-0924-YC124.pdf

MSDS

MSDS - VS-0924-YC124.pdf

COA

Certificate of Analysis Lookup

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