Mouse Anti-CD70 Recombinant Antibody Hexamer (VS-0924-YC124), CDC Enhanced (CAT#: VS-0924-YC124)
The product is a mouse anti-CD70 antibody hexamer with enhanced CDC activity. This hexameric IgG1 targets both human and mouse CD70 and includes specific mutations that enhance hexamerization. This promotes optimal C1q binding and significantly boosts complement-dependent cytotoxicity (CDC).
Specific Inquiry
Subcellular Location and Protein Expression
RNA Expression

Figure 1 IF staining of human cell line SiHa
(Immunofluorescent staining of human cell line SiHa shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/46582/1486_B2_3_selected.jpg
(Immunofluorescent staining of human cell line SiHa shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/46582/1486_B2_3_selected.jpg

Figure 2 IF staining of human cell line U-251 MG
(Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/46582/1559_D6_2_red_green.jpg
(Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/46582/1559_D6_2_red_green.jpg

Figure 3 RNA cell line category: Cell line enhanced (SiHa, THP-1, U-251 MG, U-266/70, U-266/84, U-698)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000125726-CD70
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000125726-CD70
Specifications
- Host Species
- Mouse
- Type
- Antibody hexamer
- Specificity
- Human and Mouse CD70
- Species Reactivity
- Human, Mouse
- Molecule Class
- ~ 900 kDa
- Applications
- FC, ADCC, CDC
- Conjugate
- None
- Related Disease
- Cancer
Product Property
- Clonality
- Monoclonal
- Purification
- Protein G purified
- Purity
- >95% determined as SDS-PAGE and SEC-HPLC
- Aggregation
- <5%
- Buffer
- PBS, pH 7.4
- Preservative
- No preservatives
- Storage
- Store at 4°C short term (1-2 weeks). Store at -20°C long term (12 months). Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- CD70 Molecule; Tumor Necrosis Factor Ligand Superfamily Member 7; CD70 Antigen; CD27 Ligand; CD27LG; TNFSF7; CD27-L
- Gene ID
- 970
- UniProt ID
- P32970
- Long Name
- CD70 Molecule
- Sequence Similarities
- Belongs to the tumor necrosis factor family.
- Cellular Localization
- Cell membrane; Single-pass type II membrane protein
- Post Translation Modifications
- N-glycosylated. ( P32970-CD70_HUMAN )
Glycosylation at Asn63, Tyr74, and Asn170 ( NX_P32970 [NX_P32970-1] )
- Function
- Expressed at the plasma membrane of B cells, it is the ligand of the CD27 receptor which is specifically expressed at the surface of T cells (PubMed:28011863, 28011864, 8387892).
The CD70-CD27 signaling pathway mediates antigen-specific T cell activation and expansion which in turn provides immune surveillance of B cells (PubMed:28011863, 28011864). CD70_HUMAN,P32970
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "CD70"
Select a product category from the dropdown menu below to view related products.
Please select product type
Humanized Antibodies
Human Antibodies
Neutralizing Antibodies
Blocking Antibodies
IgG Antibodies
ScFv Antibodies
Fab Antibodies
ADCC Enhanced Antibodies
Hexamer Antibodies
FC Reagents & Kits
ScFv-Fc Chimeras
Extracellular Vesicle Antibodies
IHC Kits & Antibodies
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-335LC | Human Anti-CD70 Recombinant Antibody (TAB-335LC) | ELISA | Humanized IgG1, κ |
TAB-335LC-F(E) | Human Anti-CD70 Recombinant Antibody; Fab Fragment (TAB-335LC-F(E)) | ELISA | Humanized Fab |
TAB-342LC-F(E) | Human Anti-CD70 Recombinant Antibody; Fab Fragment (TAB-342LC-F(E)) | FC | Humanized Fab |
TAB-343LC-F(E) | Human Anti-CD70 Recombinant Antibody; Fab Fragment (TAB-343LC-F(E)) | FC | Humanized Fab |
TAB-344LC-F(E) | Human Anti-CD70 Recombinant Antibody; Fab Fragment (TAB-344LC-F(E)) | FC | Humanized Fab |
Customer Reviews and Q&As
There are currently no Customer reviews or questions for VS-0924-YC124. Click the button above to contact us or submit your feedback about this product.
Popular products with customers
Application: ELISA, IP, FC, FuncS, Neut, IF, WB
Application: WB, ELISA, FC, IP, FuncS, IF, Neut
Application: IB, ELISA, FC, FuncS
Application: ELISA, FC, WB, Block
Application: WB, ELISA, FuncS, Inhib, PK, IP, SPR
Application: ELISA, IHC, FC, IP, IF, Inhib
Application: ELISA, Neut
Application: Neut, ELISA, WB, SPR, IF, EM
Application: Neut, ELISA, IF, IP, FuncS, FC
Application: ELISA, Activ, Block
For Research Use Only. Not For Clinical Use.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.